Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin
Аутори
Ušjak, Dušan![](/themes/MirageDAIS/images/orcid.png)
Novović, Katarina
![](/themes/MirageDAIS/images/orcid.png)
Filipić, Brankica
Kojić, Milan
Filipović, Nenad
![](/themes/MirageDAIS/images/orcid.png)
Stevanović, Magdalena M.
Arsenović-Ranin, Nevena
Milenković, Marina
![](/themes/MirageDAIS/images/orcid.png)
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Colistin is used as a “last resort” drug in the treatmentof carbapenem-resistant Acinetobacter baumanniiinfections. Though not the most convenient option due tothe serious side effects, this antibiotic can be very efficientif administered properly (Garnacho-Montero and Timsit,2019). However, for several years now, we are witnessinga steady emergence of colistin-resistant (ColR) strains, withthe constant threat of a sudden burst worldwide (Nowak etal., 2017). Having in mind that these strains are usuallynon-susceptible to any of the existing treatments, i.e.pandrug-resistant (PDR), the development of newtherapeutic strategies is desperately needed.In the present study, we showed that colistinsusceptibility of ColR A. baumannii strains can be fullyrestored in the presence of very low amounts of seleniumnanoparticles (SeNPs). To demonstrate potent synergisticinteractions between colistin and SeNPs, we performedcheckerboard and time-kill analyses.
Извор:
Macedonian Pharmaceutical Bulletin, 2022, 68 (Suppl. 1), 295-296Издавач:
- Macedonian Pharmaceutical Association
Напомена:
- The Seventh Congress ofPharmacy in North Macedonia with International participation 2022,october 5-9, Ohrid
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ušjak, Dušan AU - Novović, Katarina AU - Filipić, Brankica AU - Kojić, Milan AU - Filipović, Nenad AU - Stevanović, Magdalena M. AU - Arsenović-Ranin, Nevena AU - Milenković, Marina PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5133 UR - https://dais.sanu.ac.rs/123456789/15263 AB - Colistin is used as a “last resort” drug in the treatmentof carbapenem-resistant Acinetobacter baumanniiinfections. Though not the most convenient option due tothe serious side effects, this antibiotic can be very efficientif administered properly (Garnacho-Montero and Timsit,2019). However, for several years now, we are witnessinga steady emergence of colistin-resistant (ColR) strains, withthe constant threat of a sudden burst worldwide (Nowak etal., 2017). Having in mind that these strains are usuallynon-susceptible to any of the existing treatments, i.e.pandrug-resistant (PDR), the development of newtherapeutic strategies is desperately needed.In the present study, we showed that colistinsusceptibility of ColR A. baumannii strains can be fullyrestored in the presence of very low amounts of seleniumnanoparticles (SeNPs). To demonstrate potent synergisticinteractions between colistin and SeNPs, we performedcheckerboard and time-kill analyses. PB - Macedonian Pharmaceutical Association C3 - Macedonian Pharmaceutical Bulletin T1 - Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin SP - 295 EP - 296 VL - 68 (Suppl. 1) DO - 10.33320/maced.pharm.bull.2022.68.03.142 UR - https://hdl.handle.net/21.15107/rcub_dais_15263 ER -
@conference{ author = "Ušjak, Dušan and Novović, Katarina and Filipić, Brankica and Kojić, Milan and Filipović, Nenad and Stevanović, Magdalena M. and Arsenović-Ranin, Nevena and Milenković, Marina", year = "2022", abstract = "Colistin is used as a “last resort” drug in the treatmentof carbapenem-resistant Acinetobacter baumanniiinfections. Though not the most convenient option due tothe serious side effects, this antibiotic can be very efficientif administered properly (Garnacho-Montero and Timsit,2019). However, for several years now, we are witnessinga steady emergence of colistin-resistant (ColR) strains, withthe constant threat of a sudden burst worldwide (Nowak etal., 2017). Having in mind that these strains are usuallynon-susceptible to any of the existing treatments, i.e.pandrug-resistant (PDR), the development of newtherapeutic strategies is desperately needed.In the present study, we showed that colistinsusceptibility of ColR A. baumannii strains can be fullyrestored in the presence of very low amounts of seleniumnanoparticles (SeNPs). To demonstrate potent synergisticinteractions between colistin and SeNPs, we performedcheckerboard and time-kill analyses.", publisher = "Macedonian Pharmaceutical Association", journal = "Macedonian Pharmaceutical Bulletin", title = "Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin", pages = "295-296", volume = "68 (Suppl. 1)", doi = "10.33320/maced.pharm.bull.2022.68.03.142", url = "https://hdl.handle.net/21.15107/rcub_dais_15263" }
Ušjak, D., Novović, K., Filipić, B., Kojić, M., Filipović, N., Stevanović, M. M., Arsenović-Ranin, N.,& Milenković, M.. (2022). Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin. in Macedonian Pharmaceutical Bulletin Macedonian Pharmaceutical Association., 68 (Suppl. 1), 295-296. https://doi.org/10.33320/maced.pharm.bull.2022.68.03.142 https://hdl.handle.net/21.15107/rcub_dais_15263
Ušjak D, Novović K, Filipić B, Kojić M, Filipović N, Stevanović MM, Arsenović-Ranin N, Milenković M. Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin. in Macedonian Pharmaceutical Bulletin. 2022;68 (Suppl. 1):295-296. doi:10.33320/maced.pharm.bull.2022.68.03.142 https://hdl.handle.net/21.15107/rcub_dais_15263 .
Ušjak, Dušan, Novović, Katarina, Filipić, Brankica, Kojić, Milan, Filipović, Nenad, Stevanović, Magdalena M., Arsenović-Ranin, Nevena, Milenković, Marina, "Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin" in Macedonian Pharmaceutical Bulletin, 68 (Suppl. 1) (2022):295-296, https://doi.org/10.33320/maced.pharm.bull.2022.68.03.142 ., https://hdl.handle.net/21.15107/rcub_dais_15263 .