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Rare-earth (Gd 3+ ,Yb 3+ /Tm 3+ , Eu 3+ ) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging
dc.creator | Ignjatović, Nenad | |
dc.creator | Mančić, Lidija | |
dc.creator | Vuković, Marina | |
dc.creator | Stojanović, Zoran S. | |
dc.creator | Nikolić, Marko G. | |
dc.creator | Škapin, Srečo Davor | |
dc.creator | Jovanović, Sonja | |
dc.creator | Veselinović, Ljiljana | |
dc.creator | Uskoković, Vuk | |
dc.creator | Lazić, Snežana | |
dc.creator | Marković, Smilja | |
dc.creator | Lazarević, Miloš M. | |
dc.creator | Uskoković, Dragan | |
dc.date.accessioned | 2020-01-04T02:51:40Z | |
dc.date.available | 2020-01-04T02:51:40Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://www.nature.com/articles/s41598-019-52885-0 | |
dc.identifier.uri | https://dais.sanu.ac.rs/123456789/6950 | |
dc.description.abstract | Taking advantage of the flexibility of the apatite structure, nano- and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE3+ = Gd, Eu, Yb, Tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at T ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P63/m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca2+ with smaller RE3+ ions at both cation positions. The FTIR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:RE3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λex = 370 nm) due to an increased concentration of defects. The “up”- and the “down”-conversion spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders showed characteristic transitions of Tm3+ and Eu3+, respectively. Furthermore, in contrast to diamagnetic HAp, all HAp:RE3+ powders exhibited paramagnetic behavior. Cell viability tests of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders in human dental pulp stem cell cultures indicated their good biocompatibility. | en |
dc.language | en | |
dc.publisher | Springer Nature | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | Rare-earth (Gd 3+ ,Yb 3+ /Tm 3+ , Eu 3+ ) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Марковић, Смиља; Лазаревић, Милош М.; Стојановић, Зоран; Ускоковић, Драган; Лазић, Снежана; Ускоковић, Вук; Веселиновић, Љиљана; Јовановић, Соња; Шкапин, Сречо Давор; Николић, Марко Г.; Вуковић, Марина; Манчић, Лидија; Игњатовић, Ненад; | |
dc.citation.spage | 1 | |
dc.citation.epage | 15 | |
dc.citation.volume | 9 | |
dc.citation.issue | 1 | |
dc.identifier.wos | 000495370900005 | |
dc.identifier.doi | 10.1038/s41598-019-52885-0 | |
dc.identifier.scopus | 2-s2.0-85074711835 | |
dc.type.version | publishedVersion | |
dc.identifier.fulltext | https://dais.sanu.ac.rs/bitstream/id/27634/s41598-019-52885-0.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_dais_6950 |