Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite
Samo za registrovane korisnike
2015
Autori
Ignjatović, NenadAjduković, Zorica
Rajković, Jelena
Najman, Stevo
Mihailović, Dragan
Uskoković, Dragan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Hydroxyapatite (HAp) is an extensively studied material with known biocompatible and osteoconductive properties in bone tissue reconstruction. The improvement of the osteogenetic potential of HAp has been tested through modification of its structure, by replacing Ca2+ ions with Co2+ ions. In our study, we comparatively analyze the osteogenetic potential of the synthesized HAp and Co2+-substituted HAp (HAp/Co) designed on the nano-scale with the aim of specifically stimulating osteogenesis in vivo. We present a quantitative study of the microscopic organization and structure of the newly formed tissue in a bone defect after 12 weeks and 24 weeks. A quantitative analysis of the calcium, magnesium and phosphorus content in the defect and its close environment was used to determine the deposition of minerals after bone reconstruction. The defect reconstructed with HAp/Co nanoparticles (Co2+ content 12 wt%) was filled with a new tissue matrix composed of dense collagen fibers containing cen...ters of mineralization after 24 weeks. The mineral deposition rate was also higher when the defect was reconstructed with HAp/Co than when it was filled with pure HAp. A histological analysis confirmed that the alveolar bone, in which osteoporosis-induced defects were repaired using HAp/Co nanoparticles, was recuperated. © 2015 Jilin University.
Ključne reči:
advanced osteogenesis / cobalt-substituted hydroxyapatite / histomorphometry / nanoparticlesIzvor:
Journal of Bionic Engineering, 2015, 12, 4, 604-612Izdavač:
- Elsevier
Finansiranje / projekti:
- Molekularno dizajniranje nanočestica kontrolisanih morfoloških i fizičko-hemijskih karakteristika i funkcionalnih materijala na njihovoj osnovi (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
- Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41018)
DOI: 10.1016/S1672-6529(14)60150-5
ISSN: 1672-6529
WoS: 000363494700009
Scopus: 2-s2.0-84944556234
Institucija/grupa
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Ignjatović, Nenad AU - Ajduković, Zorica AU - Rajković, Jelena AU - Najman, Stevo AU - Mihailović, Dragan AU - Uskoković, Dragan PY - 2015 UR - https://dais.sanu.ac.rs/123456789/3547 AB - Hydroxyapatite (HAp) is an extensively studied material with known biocompatible and osteoconductive properties in bone tissue reconstruction. The improvement of the osteogenetic potential of HAp has been tested through modification of its structure, by replacing Ca2+ ions with Co2+ ions. In our study, we comparatively analyze the osteogenetic potential of the synthesized HAp and Co2+-substituted HAp (HAp/Co) designed on the nano-scale with the aim of specifically stimulating osteogenesis in vivo. We present a quantitative study of the microscopic organization and structure of the newly formed tissue in a bone defect after 12 weeks and 24 weeks. A quantitative analysis of the calcium, magnesium and phosphorus content in the defect and its close environment was used to determine the deposition of minerals after bone reconstruction. The defect reconstructed with HAp/Co nanoparticles (Co2+ content 12 wt%) was filled with a new tissue matrix composed of dense collagen fibers containing centers of mineralization after 24 weeks. The mineral deposition rate was also higher when the defect was reconstructed with HAp/Co than when it was filled with pure HAp. A histological analysis confirmed that the alveolar bone, in which osteoporosis-induced defects were repaired using HAp/Co nanoparticles, was recuperated. © 2015 Jilin University. PB - Elsevier T2 - Journal of Bionic Engineering T1 - Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite SP - 604 EP - 612 VL - 12 IS - 4 DO - 10.1016/S1672-6529(14)60150-5 UR - https://hdl.handle.net/21.15107/rcub_dais_3547 ER -
@article{ author = "Ignjatović, Nenad and Ajduković, Zorica and Rajković, Jelena and Najman, Stevo and Mihailović, Dragan and Uskoković, Dragan", year = "2015", abstract = "Hydroxyapatite (HAp) is an extensively studied material with known biocompatible and osteoconductive properties in bone tissue reconstruction. The improvement of the osteogenetic potential of HAp has been tested through modification of its structure, by replacing Ca2+ ions with Co2+ ions. In our study, we comparatively analyze the osteogenetic potential of the synthesized HAp and Co2+-substituted HAp (HAp/Co) designed on the nano-scale with the aim of specifically stimulating osteogenesis in vivo. We present a quantitative study of the microscopic organization and structure of the newly formed tissue in a bone defect after 12 weeks and 24 weeks. A quantitative analysis of the calcium, magnesium and phosphorus content in the defect and its close environment was used to determine the deposition of minerals after bone reconstruction. The defect reconstructed with HAp/Co nanoparticles (Co2+ content 12 wt%) was filled with a new tissue matrix composed of dense collagen fibers containing centers of mineralization after 24 weeks. The mineral deposition rate was also higher when the defect was reconstructed with HAp/Co than when it was filled with pure HAp. A histological analysis confirmed that the alveolar bone, in which osteoporosis-induced defects were repaired using HAp/Co nanoparticles, was recuperated. © 2015 Jilin University.", publisher = "Elsevier", journal = "Journal of Bionic Engineering", title = "Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite", pages = "604-612", volume = "12", number = "4", doi = "10.1016/S1672-6529(14)60150-5", url = "https://hdl.handle.net/21.15107/rcub_dais_3547" }
Ignjatović, N., Ajduković, Z., Rajković, J., Najman, S., Mihailović, D.,& Uskoković, D.. (2015). Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite. in Journal of Bionic Engineering Elsevier., 12(4), 604-612. https://doi.org/10.1016/S1672-6529(14)60150-5 https://hdl.handle.net/21.15107/rcub_dais_3547
Ignjatović N, Ajduković Z, Rajković J, Najman S, Mihailović D, Uskoković D. Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite. in Journal of Bionic Engineering. 2015;12(4):604-612. doi:10.1016/S1672-6529(14)60150-5 https://hdl.handle.net/21.15107/rcub_dais_3547 .
Ignjatović, Nenad, Ajduković, Zorica, Rajković, Jelena, Najman, Stevo, Mihailović, Dragan, Uskoković, Dragan, "Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite" in Journal of Bionic Engineering, 12, no. 4 (2015):604-612, https://doi.org/10.1016/S1672-6529(14)60150-5 ., https://hdl.handle.net/21.15107/rcub_dais_3547 .