Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite
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2011
Authors
Vukomanović, MarijaZavašnik-Bergant, Tina
Bračko, Ines
Škapin, Srečo Davor
Ignjatović, Nenad
Radmilović, Velimir
Uskoković, Dragan
Article (Published version)
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A step-by-step analysis of the formation and the drug loading of the poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite was carried out in a perspective of the following parameters: the structure, the morphology and the adsorption/desorption properties of the composite's bioceramic part. The authors demonstrated the importance of the material's capacity to form a fine dispersion of solid HAp particles, as an initial step, for the further loading of the drug and for the formation of the core–shell structures. The nanometer-sized rods of HAp have the capacity of ensuring a rapid adsorption and a controlled desorption of the drug from their surface, and they can act as a nucleating site for the formation of polymeric cores. Each component of this material was labeled with fluorescence dye, which enabled an insight into the distribution of the components in the core–shells that were obtained as the final outcome. Such an analysis showed a high level of uniformity among the ...cores enclosed within polymeric shells. From a practical perspective, the labeling of each component of the composite can be regarded as an additional functionality of the material: labeling can enable us to monitor its action during the healing process. This ability to be easily detected is expected to enhance the procedure for the controlled delivery of antibiotics after their local implantation of carriers loaded with the antibiotic and to provide more careful control over this process.
Keywords:
poly(d,l-lactide-co-glycolide)/hydroxyapatite / core-shell nanoparticles / nanorods / ultrasoundSource:
Colloids and Surfaces B: Biointerfaces, 2011, 87, 2, 226-235Publisher:
- Elsevier BV
Funding / projects:
- Reinforcing of Nanotechnology and Functional Materials Centre (EU-FP7-245916)
- Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
- Development, characterization and application nanostructured and composite electrocatalysts and interactive supports for fuel cells and water electrolysis (RS-MESTD-Basic Research (BR or ON)-172054)
DOI: 10.1016/j.colsurfb.2011.05.023
ISSN: 09277765
WoS: 000294142900004
Scopus: 2-s2.0-79960417417
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Vukomanović, Marija AU - Zavašnik-Bergant, Tina AU - Bračko, Ines AU - Škapin, Srečo Davor AU - Ignjatović, Nenad AU - Radmilović, Velimir AU - Uskoković, Dragan PY - 2011 UR - https://dais.sanu.ac.rs/123456789/14364 AB - A step-by-step analysis of the formation and the drug loading of the poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite was carried out in a perspective of the following parameters: the structure, the morphology and the adsorption/desorption properties of the composite's bioceramic part. The authors demonstrated the importance of the material's capacity to form a fine dispersion of solid HAp particles, as an initial step, for the further loading of the drug and for the formation of the core–shell structures. The nanometer-sized rods of HAp have the capacity of ensuring a rapid adsorption and a controlled desorption of the drug from their surface, and they can act as a nucleating site for the formation of polymeric cores. Each component of this material was labeled with fluorescence dye, which enabled an insight into the distribution of the components in the core–shells that were obtained as the final outcome. Such an analysis showed a high level of uniformity among the cores enclosed within polymeric shells. From a practical perspective, the labeling of each component of the composite can be regarded as an additional functionality of the material: labeling can enable us to monitor its action during the healing process. This ability to be easily detected is expected to enhance the procedure for the controlled delivery of antibiotics after their local implantation of carriers loaded with the antibiotic and to provide more careful control over this process. PB - Elsevier BV T2 - Colloids and Surfaces B: Biointerfaces T1 - Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite SP - 226 EP - 235 VL - 87 IS - 2 DO - 10.1016/j.colsurfb.2011.05.023 UR - https://hdl.handle.net/21.15107/rcub_dais_14364 ER -
@article{ author = "Vukomanović, Marija and Zavašnik-Bergant, Tina and Bračko, Ines and Škapin, Srečo Davor and Ignjatović, Nenad and Radmilović, Velimir and Uskoković, Dragan", year = "2011", abstract = "A step-by-step analysis of the formation and the drug loading of the poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite was carried out in a perspective of the following parameters: the structure, the morphology and the adsorption/desorption properties of the composite's bioceramic part. The authors demonstrated the importance of the material's capacity to form a fine dispersion of solid HAp particles, as an initial step, for the further loading of the drug and for the formation of the core–shell structures. The nanometer-sized rods of HAp have the capacity of ensuring a rapid adsorption and a controlled desorption of the drug from their surface, and they can act as a nucleating site for the formation of polymeric cores. Each component of this material was labeled with fluorescence dye, which enabled an insight into the distribution of the components in the core–shells that were obtained as the final outcome. Such an analysis showed a high level of uniformity among the cores enclosed within polymeric shells. From a practical perspective, the labeling of each component of the composite can be regarded as an additional functionality of the material: labeling can enable us to monitor its action during the healing process. This ability to be easily detected is expected to enhance the procedure for the controlled delivery of antibiotics after their local implantation of carriers loaded with the antibiotic and to provide more careful control over this process.", publisher = "Elsevier BV", journal = "Colloids and Surfaces B: Biointerfaces", title = "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite", pages = "226-235", volume = "87", number = "2", doi = "10.1016/j.colsurfb.2011.05.023", url = "https://hdl.handle.net/21.15107/rcub_dais_14364" }
Vukomanović, M., Zavašnik-Bergant, T., Bračko, I., Škapin, S. D., Ignjatović, N., Radmilović, V.,& Uskoković, D.. (2011). Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite. in Colloids and Surfaces B: Biointerfaces Elsevier BV., 87(2), 226-235. https://doi.org/10.1016/j.colsurfb.2011.05.023 https://hdl.handle.net/21.15107/rcub_dais_14364
Vukomanović M, Zavašnik-Bergant T, Bračko I, Škapin SD, Ignjatović N, Radmilović V, Uskoković D. Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite. in Colloids and Surfaces B: Biointerfaces. 2011;87(2):226-235. doi:10.1016/j.colsurfb.2011.05.023 https://hdl.handle.net/21.15107/rcub_dais_14364 .
Vukomanović, Marija, Zavašnik-Bergant, Tina, Bračko, Ines, Škapin, Srečo Davor, Ignjatović, Nenad, Radmilović, Velimir, Uskoković, Dragan, "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite" in Colloids and Surfaces B: Biointerfaces, 87, no. 2 (2011):226-235, https://doi.org/10.1016/j.colsurfb.2011.05.023 ., https://hdl.handle.net/21.15107/rcub_dais_14364 .