Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice
Само за регистроване кориснике
2004
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Histopathologic analysis of the tissue with HAp/PLLA implants was made and the leukocyte formula and chemiluminescence response of peritoneal phagocytes 2, 7 and 12 weeks after intraperitoneal implantation studied. Implants were made of HAp/PLLA biocomposites with PLLA molecular weights of 50,000 (HAp/PLLA(50)) and 430,000 g/mol (HAp/PLLA(430)) and of crushed devitalized femur bone of a young Wistar rat. Leukocyte formula and chemiluminescence of peritoneal phagocytes showed no systemic inflammatory response. The studied implants caused locally weak inflammatory reaction. The resorption of implants ranges in intensity (polymer resorption, i.e. disappearance rate), from the highest with the bone implants, low with HAp/PLLA(50), to the lowest with the HAp/PLLA(430) implants. Good resorption of the biocomposites and its mutual ingrowth with connective tissue prove their good biocompatibility.
Кључне речи:
hydroxyapatite/poly‐L‐lactide / composite materials / biomaterials / bone implants / intraperitoneal implantationИзвор:
Bio-Medical Materials and Engineering, 2004, 14, 1, 61-70Издавач:
- IOS Press
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Najman, Stevo AU - Savić, Vojin AU - Đorđević, Lj. AU - Ignjatović, Nenad AU - Uskoković, Dragan PY - 2004 UR - https://dais.sanu.ac.rs/123456789/14301 AB - Histopathologic analysis of the tissue with HAp/PLLA implants was made and the leukocyte formula and chemiluminescence response of peritoneal phagocytes 2, 7 and 12 weeks after intraperitoneal implantation studied. Implants were made of HAp/PLLA biocomposites with PLLA molecular weights of 50,000 (HAp/PLLA(50)) and 430,000 g/mol (HAp/PLLA(430)) and of crushed devitalized femur bone of a young Wistar rat. Leukocyte formula and chemiluminescence of peritoneal phagocytes showed no systemic inflammatory response. The studied implants caused locally weak inflammatory reaction. The resorption of implants ranges in intensity (polymer resorption, i.e. disappearance rate), from the highest with the bone implants, low with HAp/PLLA(50), to the lowest with the HAp/PLLA(430) implants. Good resorption of the biocomposites and its mutual ingrowth with connective tissue prove their good biocompatibility. PB - IOS Press T2 - Bio-Medical Materials and Engineering T1 - Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice SP - 61 EP - 70 VL - 14 IS - 1 UR - https://hdl.handle.net/21.15107/rcub_dais_14301 ER -
@article{ author = "Najman, Stevo and Savić, Vojin and Đorđević, Lj. and Ignjatović, Nenad and Uskoković, Dragan", year = "2004", abstract = "Histopathologic analysis of the tissue with HAp/PLLA implants was made and the leukocyte formula and chemiluminescence response of peritoneal phagocytes 2, 7 and 12 weeks after intraperitoneal implantation studied. Implants were made of HAp/PLLA biocomposites with PLLA molecular weights of 50,000 (HAp/PLLA(50)) and 430,000 g/mol (HAp/PLLA(430)) and of crushed devitalized femur bone of a young Wistar rat. Leukocyte formula and chemiluminescence of peritoneal phagocytes showed no systemic inflammatory response. The studied implants caused locally weak inflammatory reaction. The resorption of implants ranges in intensity (polymer resorption, i.e. disappearance rate), from the highest with the bone implants, low with HAp/PLLA(50), to the lowest with the HAp/PLLA(430) implants. Good resorption of the biocomposites and its mutual ingrowth with connective tissue prove their good biocompatibility.", publisher = "IOS Press", journal = "Bio-Medical Materials and Engineering", title = "Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice", pages = "61-70", volume = "14", number = "1", url = "https://hdl.handle.net/21.15107/rcub_dais_14301" }
Najman, S., Savić, V., Đorđević, Lj., Ignjatović, N.,& Uskoković, D.. (2004). Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice. in Bio-Medical Materials and Engineering IOS Press., 14(1), 61-70. https://hdl.handle.net/21.15107/rcub_dais_14301
Najman S, Savić V, Đorđević L, Ignjatović N, Uskoković D. Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice. in Bio-Medical Materials and Engineering. 2004;14(1):61-70. https://hdl.handle.net/21.15107/rcub_dais_14301 .
Najman, Stevo, Savić, Vojin, Đorđević, Lj., Ignjatović, Nenad, Uskoković, Dragan, "Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice" in Bio-Medical Materials and Engineering, 14, no. 1 (2004):61-70, https://hdl.handle.net/21.15107/rcub_dais_14301 .