Modulation of redox parameters in rat liver induced by flaxseed oil
Autori
Todorović, A.Pavlović, I.
Pejić, S.
Miletić Vukajlović, J.
Veljković, F.
Filipović Tričković, J.
Valenta Šobot, A.
Martinović, J.
Guševac Stojanović, I.
Stojanović, Zoran
Drakulić, Dunja
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Flaxseed oil, extracted from ripened flaxseeds, is functional food source that is associated with health benefits in many diseases, including cardiovascular,
cancer, osteoporosis, etc. Besides saturated fatty acids and monounsaturated fatty acids, it also contains easily oxidized polyunsaturated fatty acids of the n-3 family. In current study, we tested the effects of commercial flaxseed oil in rat liver by measuring parameters related to free radical challenge (pro/antioxidant balance (PAB), lipid peroxidation (LPO) products and glutathione (GSH) level). Overall, applied treatment maintains general prooxidant load and antioxidant capacity since the level of PAB was unchanged. However, it exerts significant modulatory effect on particular redox parameters by increasing the amount of LPO products and consequently the susceptibility of tissue to free radical oxidative damage, which challenges the antioxidant defence system that
in return elevates GSH concentration.
Ključne reči:
flaxseed oil / rat liver / redox parametersIzvor:
Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021, 2021, 180-183Izdavač:
- Belgrade : Vinča Institute of Nuclear Sciences
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (RS-MESTD-inst-2020-200017)
Institucija/grupa
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Todorović, A. AU - Pavlović, I. AU - Pejić, S. AU - Miletić Vukajlović, J. AU - Veljković, F. AU - Filipović Tričković, J. AU - Valenta Šobot, A. AU - Martinović, J. AU - Guševac Stojanović, I. AU - Stojanović, Zoran AU - Drakulić, Dunja PY - 2021 UR - https://dais.sanu.ac.rs/123456789/12379 AB - Flaxseed oil, extracted from ripened flaxseeds, is functional food source that is associated with health benefits in many diseases, including cardiovascular, cancer, osteoporosis, etc. Besides saturated fatty acids and monounsaturated fatty acids, it also contains easily oxidized polyunsaturated fatty acids of the n-3 family. In current study, we tested the effects of commercial flaxseed oil in rat liver by measuring parameters related to free radical challenge (pro/antioxidant balance (PAB), lipid peroxidation (LPO) products and glutathione (GSH) level). Overall, applied treatment maintains general prooxidant load and antioxidant capacity since the level of PAB was unchanged. However, it exerts significant modulatory effect on particular redox parameters by increasing the amount of LPO products and consequently the susceptibility of tissue to free radical oxidative damage, which challenges the antioxidant defence system that in return elevates GSH concentration. PB - Belgrade : Vinča Institute of Nuclear Sciences C3 - Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 T1 - Modulation of redox parameters in rat liver induced by flaxseed oil SP - 180 EP - 183 UR - https://hdl.handle.net/21.15107/rcub_dais_12379 ER -
@conference{ author = "Todorović, A. and Pavlović, I. and Pejić, S. and Miletić Vukajlović, J. and Veljković, F. and Filipović Tričković, J. and Valenta Šobot, A. and Martinović, J. and Guševac Stojanović, I. and Stojanović, Zoran and Drakulić, Dunja", year = "2021", abstract = "Flaxseed oil, extracted from ripened flaxseeds, is functional food source that is associated with health benefits in many diseases, including cardiovascular, cancer, osteoporosis, etc. Besides saturated fatty acids and monounsaturated fatty acids, it also contains easily oxidized polyunsaturated fatty acids of the n-3 family. In current study, we tested the effects of commercial flaxseed oil in rat liver by measuring parameters related to free radical challenge (pro/antioxidant balance (PAB), lipid peroxidation (LPO) products and glutathione (GSH) level). Overall, applied treatment maintains general prooxidant load and antioxidant capacity since the level of PAB was unchanged. However, it exerts significant modulatory effect on particular redox parameters by increasing the amount of LPO products and consequently the susceptibility of tissue to free radical oxidative damage, which challenges the antioxidant defence system that in return elevates GSH concentration.", publisher = "Belgrade : Vinča Institute of Nuclear Sciences", journal = "Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021", title = "Modulation of redox parameters in rat liver induced by flaxseed oil", pages = "180-183", url = "https://hdl.handle.net/21.15107/rcub_dais_12379" }
Todorović, A., Pavlović, I., Pejić, S., Miletić Vukajlović, J., Veljković, F., Filipović Tričković, J., Valenta Šobot, A., Martinović, J., Guševac Stojanović, I., Stojanović, Z.,& Drakulić, D.. (2021). Modulation of redox parameters in rat liver induced by flaxseed oil. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 Belgrade : Vinča Institute of Nuclear Sciences., 180-183. https://hdl.handle.net/21.15107/rcub_dais_12379
Todorović A, Pavlović I, Pejić S, Miletić Vukajlović J, Veljković F, Filipović Tričković J, Valenta Šobot A, Martinović J, Guševac Stojanović I, Stojanović Z, Drakulić D. Modulation of redox parameters in rat liver induced by flaxseed oil. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021. 2021;:180-183. https://hdl.handle.net/21.15107/rcub_dais_12379 .
Todorović, A., Pavlović, I., Pejić, S., Miletić Vukajlović, J., Veljković, F., Filipović Tričković, J., Valenta Šobot, A., Martinović, J., Guševac Stojanović, I., Stojanović, Zoran, Drakulić, Dunja, "Modulation of redox parameters in rat liver induced by flaxseed oil" in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 (2021):180-183, https://hdl.handle.net/21.15107/rcub_dais_12379 .