Дигитални архив издања САНУ
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ДАИС
  • Институт техничких наука САНУ
  • Glavna kolekcija
  • Преглед рада
  •   ДАИС
  • Институт техничких наука САНУ
  • Glavna kolekcija
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

PLGA/Nano-ZnO Composite Particles for Use in Biomedical Applications: Preparation, Characterization, and Antimicrobial Activity

Thumbnail
2016
Stankovic_Journal of Nanomaterials_2016_9425289.pdf (3.203Mb)
Аутори
Stanković, Ana
Sezen, Meltem
Milenković, Marina
Kaišarević, Sonja
Andrić, Nebojša
Stevanović, Magdalena
Чланак у часопису
Метаподаци
Приказ свих података о документу
Апстракт
Copolymer poly (DL-lactide-co-glycolide) (PLGA) is extensively investigated for various biomedical applications such as controlled drug delivery or carriers in the tissue engineering. In addition, zinc oxide (ZnO) is widely used in biomedicine especially for materials like dental composites, as a constituent of creams for the treatment of a variety of skin irritations, to enhance the antibacterial activity of different medicaments and so on. Uniform, spherical ZnO nanoparticles (nano-ZnO) have been synthesized via microwave synthesis method. In addition to obtaining nano-ZnO, a further aim was to examine their immobilization in the PLGA polymer matrix (PLGA/nano-ZnO) and this was done by a simple physicochemical solvent/nonsolvent method. The samples were characterized by X-ray diffraction, scanning electron microscopy, laser diffraction particle size analyzer, differential thermal analysis, and thermal gravimetric analysis. The synthesized PLGA/nano-ZnO particles are spherical, unifor...m, and with diameters below 1 µm. The influence of the different solvents and the drying methods during the synthesis was investigated too. The biocompatibility of the samples is discussed in terms of in vitro toxicity on human hepatoma HepG2 cells by application of MTT assay and the antimicrobial activity was evaluated by broth microdilution method against different groups of microorganisms (Gram-positive bacteria, Gram-negative bacteria, and yeast Candida albicans).

Кључне речи:
poly (DL-lactide-co-glycolide) / PLGA / ZnO / composite materials / nanomaterials
Извор:
Journal of Nanomaterials, 2016
Издавач:
  • Hindawi
Пројекти:
  • Молекуларно дизајнирање наночестица контролисаних морфолошких и физичко-хемијских карактеристика и функционалних материјала на њиховој основи (RS-45004)

DOI: 10.1155/2016/9425289

ISSN: 1687-4110 (Print) 1687-4129 (Online)

[ Google Scholar ]
URI
http://dais.sanu.ac.rs/123456789/901
http://www.itn.sanu.ac.rs/opus4/frontdoor/index/index/docId/1183
http://www.itn.sanu.ac.rs/opus4/files/1183/Stankovic_Journal%20of%20Nanomaterials_2016_9425289.pdf
Колекције
  • Glavna kolekcija
Институција
Институт техничких наука САНУ

DSpace software copyright © 2002-2015  DuraSpace
О ДАИС репозиторијуму | Пошаљите запажања

RCUB
 

 

Комплетан репозиторијумИнституцијеАуториОва институцијаАутори

DSpace software copyright © 2002-2015  DuraSpace
О ДАИС репозиторијуму | Пошаљите запажања

RCUB