Приказ основних података о документу

dc.creatorFilipović, Nenad
dc.creatorJeremić, Sanja
dc.creatorĐokić, Lidija
dc.creatorRažić, Slavica
dc.creatorStevanović, Magdalena
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2016
dc.identifier.isbn978-86-80321-32-5
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/886
dc.description.abstractOne of the most prominent properties of poly (є-caprolactone) (PCL) as a biodegradable polymer is slow degradation rate. Due to this advantage the PCL is often used in versatile systems for drug delivery or tissue engineering. When it comes to drug delivery systems, this property of PCL provides the slow release of encapsulated medicaments in order to avoid acute toxicity i.e. to enhance therapeutic efficiency, or protects medicaments from "aggressive" environment and ensures prolonged effect. Selenium nanoparticles (SeNp) recently gained attention as a potential candidate for cancer therapy and prevention with antibacterial properties as well. The major drawback of SeNp is substantial risk of toxicity. Degradation itself is a function of several material properties as well as the nature of surrounding medium. In this work it is examined the release of SeNp from PCL microparticles during the degradation in four different mediums: phosphate buffered saline (PBS), solution of lipase isolated from porcine pancreas in PBS, 0.1 M hydrochloric acid (HCL) and Psseudomonas aeruginosa cell free extract in PBS. The main idea was to compare the release of the selenium nanoparticles in physiological conditions (the first three medium) and in the pathological conditions (the fourth medium), respectively. Firstly, the PCL/SeNp were suspended in adequate medium and placed in water bath at 37 °C. At exact times, samples were collected and examined by different techniques: X-ray diffraction (XRD), inductively coupled plasma-atomic emission spectroscopy (ICP-AES), scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS), differential scanning calorimetry (DSC). The release of selenium nanoparticles in physiological conditions occurred in a very slow manner without burst release while in the presence of bacterial extract the release was much more pronounced, even after 24 h.en
dc.format(2016) 8-8
dc.formatapplication/pdf
dc.languageen
dc.publisherBelgrade : Institute of Technical Sciences of SASA
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsopenAccess
dc.sourceProgram and the Book of Abstracts / Fifteenth Young Researchers' Conference Materials Sciences and Engineering, December 7-9, 2016, Belgradeen
dc.subjectpoly(є-caprolactone)
dc.subjectselenium nanoparticles
dc.subjectX-ray diffraction
dc.subjectplasma-atomic emission spectroscopy
dc.subjectSEM-EDS
dc.titleComparison of the release of selenium nanoparticles from poly (є-caprolactone) microparticles in four different degradation mediumsen
dc.typeconferenceObject
dc.rights.licenseBY-NC-ND
dcterms.abstractРажић, Славица; Јеремић, Сања; Филиповић, Ненад; Ђокић, Лидија; Стевановић, Магдалена; Comparison of the release of selenium nanoparticles from poly (є-caprolactone) microparticles in four different degradation mediums;
dc.citation.spage8
dc.citation.epage8
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/886/Filipovic_15YRC.pdf


Документи

Thumbnail

Овај рад се појављује у следећим колекцијама

Приказ основних података о документу