Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines
Апстракт
The aim of this study was to examine the effects of nanoparticles of calcium phosphate/poly-(DL-lactide-co-glycolide) (NPs-CP/PLGA) on viability and growth of different cell lines in vitro. HeLa and MDCK cells were incubated with different concentrations of suspension and extract of NPs-CP/PLGA. Concentrations of suspension were in the range from 1.6 μg/ml to 5000 μg/ml and extract in the range from 2.5% to 50%. After incubation, MTT test was performed. Our results indicate that examined nanomaterial shows different effects depending on type of the cells, applied concentration of nanomaterial as well as whether it is examined suspension or extract.
Кључне речи:
calcium phosphate / poly- (DL-lactide-co-glycolide) / PLGA / cell lines / biomaterialsИзвор:
Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia, 2011, 6-6Издавач:
- Belgrade : Institute of Technical Sciences of SASA
Финансирање / пројекти:
- Молекуларно дизајнирање наночестица контролисаних морфолошких и физичко-хемијских карактеристика и функционалних материјала на њиховој основи (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
- Виртуелни коштано зглобни систем човека и његова примена у претклиничкој и клиничкој пракси (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41017)
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Najman, Stevo AU - Stojanović, Sanja AU - Najdanović, Jelena AU - Ignjatović, Nenad AU - Uskoković, Dragan PY - 2011 UR - https://dais.sanu.ac.rs/123456789/698 AB - The aim of this study was to examine the effects of nanoparticles of calcium phosphate/poly-(DL-lactide-co-glycolide) (NPs-CP/PLGA) on viability and growth of different cell lines in vitro. HeLa and MDCK cells were incubated with different concentrations of suspension and extract of NPs-CP/PLGA. Concentrations of suspension were in the range from 1.6 μg/ml to 5000 μg/ml and extract in the range from 2.5% to 50%. After incubation, MTT test was performed. Our results indicate that examined nanomaterial shows different effects depending on type of the cells, applied concentration of nanomaterial as well as whether it is examined suspension or extract. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia T1 - Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines SP - 6 EP - 6 UR - https://hdl.handle.net/21.15107/rcub_dais_698 ER -
@conference{ author = "Najman, Stevo and Stojanović, Sanja and Najdanović, Jelena and Ignjatović, Nenad and Uskoković, Dragan", year = "2011", abstract = "The aim of this study was to examine the effects of nanoparticles of calcium phosphate/poly-(DL-lactide-co-glycolide) (NPs-CP/PLGA) on viability and growth of different cell lines in vitro. HeLa and MDCK cells were incubated with different concentrations of suspension and extract of NPs-CP/PLGA. Concentrations of suspension were in the range from 1.6 μg/ml to 5000 μg/ml and extract in the range from 2.5% to 50%. After incubation, MTT test was performed. Our results indicate that examined nanomaterial shows different effects depending on type of the cells, applied concentration of nanomaterial as well as whether it is examined suspension or extract.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia", title = "Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines", pages = "6-6", url = "https://hdl.handle.net/21.15107/rcub_dais_698" }
Najman, S., Stojanović, S., Najdanović, J., Ignjatović, N.,& Uskoković, D.. (2011). Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia Belgrade : Institute of Technical Sciences of SASA., 6-6. https://hdl.handle.net/21.15107/rcub_dais_698
Najman S, Stojanović S, Najdanović J, Ignjatović N, Uskoković D. Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia. 2011;:6-6. https://hdl.handle.net/21.15107/rcub_dais_698 .
Najman, Stevo, Stojanović, Sanja, Najdanović, Jelena, Ignjatović, Nenad, Uskoković, Dragan, "Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines" in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia (2011):6-6, https://hdl.handle.net/21.15107/rcub_dais_698 .