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dc.creatorIgnjatović, Nenad
dc.creatorAjduković, Zorica
dc.creatorDrmanić, Saša Ž.
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2011
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/679
dc.description.abstractMultifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were performed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.en
dc.format(2011) 68-68
dc.formatapplication/pdf
dc.languageen
dc.publisherBelgrade : Materials Research Society of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsopenAccess
dc.sourceThe Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstractsen
dc.subjecthydroxyapatite
dc.subjectvitamin D
dc.subjectcontrolled delivery
dc.subjectnanoparticles
dc.subjectosteogenesis
dc.titleMultifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3en
dc.typeconferenceObject
dc.rights.licenseBY-NC-ND
dcterms.abstractAјдиковић, Зорица; Ускоковић, Драган; Дрманић, С.; Игњатовић, Ненад;
dc.citation.spage68
dc.citation.epage68
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/21646/676.pdf


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