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dc.creatorJovanović, Ivana
dc.creatorPetković, Marijana
dc.creatorJordović, Branka
dc.creatorIgnjatović, Nenad
dc.creatorUskoković, Dragan
dc.date.accessioned2019-07-04T08:56:05Z
dc.date.available2019-07-04T08:56:05Z
dc.date.issued2007
dc.identifier.isbn9788680321110
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/6282
dc.description.abstractWorldwide, there is u currently considerable care for the development of biodegradable microspheres as systems for controlled release of medicaments. The major disadvantage of traditional administration routes of medicaments is the need for frequent repetition. Encapsulation has been proven to be an effective vehicle for the controlled delivery of various medicaments. The encapsulation efficiency and release kinetics of the medicaments have been found to be dependent upon the size of the microspheres synthesized. The aim of this study was to formulate microparticles from poly-dl-lactide (PDLLA) by modified precipitation method. Bovine serum albumin (BSA) was used as a model protein for encapsulation. The surfactant polyvinyl alcohol (PVA) was incorporated to increase encapsulation efficiency and to achieve PDLLA spheres with desired size. The main focus was to study the effect of co-solvent selection (methanol or ethanol), PVA concentration, chloroform-to-water ratio, the speed and time of homogenization and solvent removal rate on the properties of microparticles. The average size and morphology of microparticles varied substantially among these preparation conditions. An increase in stirring rate and time of homogenization and concentration of stabilizer agent were found to reduce moderately the size of microparticles. Other process parameters had limited influence on particle size.sr
dc.language.isoensr
dc.publisherBelgrade : Institute of Technical Sciences of SASAsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//sr
dc.rightsopenAccesssr
dc.sourceProgramme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007sr
dc.subjectpoly-dl-lactide (PDLLA)sr
dc.subjectbovine serum albumin (BSA)sr
dc.subjectpolyvinyl alcohol (PVA)sr
dc.subjectpoli-DL-laktidsr
dc.subjectgoveđi serumski albuminsr
dc.subjectpolivinil-alkoholsr
dc.titlePDLLA microparticles containing BSA: effect of formulation variables on size distributionsr
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractПетковић, Маријана; Игњатовић, Ненад; Ускоковић, Драган; Јордовић, Бранка; Јовановић, Ивана; ПДЛЛA мицропартицлес цонтаининг БСA: еффецт оф формулатион вариаблес он сизе дистрибутион; ПДЛЛA мицропартицлес цонтаининг БСA: еффецт оф формулатион вариаблес он сизе дистрибутион;
dc.citation.spage170
dc.citation.epage170
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/19680/Jovanovic_YUCOMAT 2007_170.pdf


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