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dc.creatorIgnjatović, Nenad
dc.creatorAjduković, Zorica
dc.creatorSavić, Vojin
dc.creatorNajman, Stevo
dc.creatorMihailović, Dragan
dc.creatorVasiljević, Perica
dc.creatorStojanović, Zoran S.
dc.creatorUskoković, Vuk
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2013
dc.identifier.issn0957-4530
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/572
dc.description.abstractIndications exist that paramagnetic calcium phosphates may be able to promote regeneration of bone faster than their regular, diamagnetic counterparts. In this study, analyzed was the influence of paramagnetic cobalt-substituted hydroxyapatite nanoparticles on osteoporotic alveolar bone regeneration in rats. Simultaneously, biocompatibility of the material was tested in vitro, on osteoblastic MC3T3-E1 and epithelial Caco-2 cells in culture. The material was shown to be biocompatible and nontoxic when added to epithelial monolayers in vitro, while it caused a substantial decrease in the cell viability as well as deformation of the cytoskeleton and cell morphology when incubated with the osteoblastic cells. In the course of 6 months after the implantation of the material containing different amounts of cobalt, ranging from 5 to 12 wt%, in the osteoporotic alveolar bone of the lower jaw, the following parameters were investigated: histopathological parameters, alkaline phosphatase and alveolar bone density. The best result in terms of osteoporotic bone tissue regeneration was observed for hydroxyapatite nanoparticles with the largest content of cobalt ions. The histological analysis showed a high level of reparatory ability of the nanoparticulate material implanted in the bone defect, paralleled by a corresponding increase in the alveolar bone density. The combined effect of growth factors from autologous plasma admixed to cobalt-substituted hydroxyapatite was furthermore shown to have a crucial effect on the augmented osteoporotic bone regeneration upon the implantation of the biomaterial investigated in this study.en
dc.format(2013) -
dc.formatapplication/pdf
dc.languageen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.relationUnited States National Institutes of Health (NIH) / National Institute of Dental and Craniofacial Research (NIDCR), Grant K99-DE021416
dc.rightsopenAccess
dc.sourceJournal of Materials Science: Materials in Medicine
dc.subjectbone regeneration
dc.subjectcobalt-substituted hydroxyapatite
dc.subjectnanoparticles
dc.subjectosteoporosis
dc.titleNanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bonesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСавић, Војин; Aјдуковић, Зорица; Игњатовић, Ненад; Ускоковић, Драган; Ускоковић, Вук; Стојановић, Зоран; Васиљевић, Перица; Михаиловић, Драган; Најман, Стево;
dc.citation.spage343
dc.citation.epage354
dc.citation.volume24
dc.citation.issue2
dc.identifier.wos000314775100008
dc.identifier.doi10.1007/s10856-012-4793-1
dc.identifier.pmid23090835
dc.identifier.scopus2-s2.0-84878374725
dc.type.versionacceptedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/5462/nihms416972.pdf


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