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dc.creatorIgnjatović, Nenad
dc.creatorVranješ Đurić, Sanja
dc.creatorMitić, Žarko
dc.creatorJanković, Drina
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2014
dc.identifier.issn0928-4931
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/539
dc.description.abstractIn this study, we have investigated the synthesis of nanoparticles of hydroxyapatite (HAp) and hydroxyapatite coated with chitosan (HAp/Ch) and the chitosan-poly-d,l-lactide-co-glycolide polymer blend (HAp/Ch-PLGA) as an organ-targeting system. We have examined and defined the final destination, as well as the dynamics and the pathways of the synthesized particles following intravenous administration in vivo. The XRD, ZP, FT-IR and SEM analyses have confirmed that the hydroxyapatite nanoparticles with d50 = 72 nm are coated with polymers. Radioactive 125-Iodine (125I), a low energy gamma emitter, was used to develop a novel in situ method for the radiolabeling of particles and investigation of their biodistribution. 125I-labeled particles exhibited high stability in saline and serum over the second day, which justified their use in the following in vivo studies. The biodistribution of 125I-labeled particles after intravenous injection in rats differed significantly: HAp particles mostly targeted the liver, HAp/Ch the spleen and the liver, while HAp/Ch-PLGA targeted the lungs. Twenty-four hours post injection, HAp particles were excreted completely, while both 125I-HAp/Ch and 125I-HAp/Ch-PLGA were retained in the body for a prolonged period of time with more than 20% of radioactivity still found in different organs.en
dc.format43 (2014) 439-436
dc.languageen
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsrestrictedAccess
dc.sourceMaterials Science and Engineering: Cen
dc.subjectnano hydroxyapatite
dc.subjectchitosan
dc.subjectorgan targeting
dc.subjectin situ 125I-labeling
dc.subjectbiodistribution
dc.titleInvestigating an organ-targeting platform based on hydroxyapatite nanoparticles using a novel in situ method of radioactive 125Iodine labelingen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВрањеш Ђурић, Сања; Ускоковић, Драган; Јанковић, Дрина; Митић, Жарко; Игњатовић, Ненад;
dc.citation.spage439
dc.citation.epage436
dc.citation.volume43
dc.identifier.wos000342529000054
dc.identifier.doi10.1016/j.msec.2014.07.046
dc.identifier.pmid25175234
dc.identifier.scopus2-s2.0-84905381787
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/539/paper807-536.pdf


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Приказ основних података о документу