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dc.creatorStupar, Petar
dc.creatorStevanović, Magdalena
dc.creatorFilipović, Nenad
dc.creatorPavlović, Vladimir B.
dc.creatorNunić, Jana
dc.creatorCundrič, Sandra
dc.creatorFilipič, Metka
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2012
dc.identifier.isbn9788673061221
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/531
dc.description.abstractA common limitation of using polymeric micro and nanoparticles in long-term conservation is due to their poor physical and chemical stability. Freeze-drying is one of the most convenient methods that enable further reconstitution of micro and nanoparticles for therapeutical use. Nevertheless, this process generates various stresses during freezing and desiccation steps. The aim of this study was to evaluate different cryoprotectants (protective excipients that are usually added to increase stability upon storage and protect the particles from freezing stress): sugars (glucose and sucrose) and polymers (PVA and PGA), on the outcome of freeze-dried poly(ε-caprolactone) micro and nanospheres. The best freeze-drying results in terms of morphological characteristics, analyzed with SEM, were achieved with glucose at concentration of 1%. The FTIR analysis confirmed that the molecular structure of PCL particles remained the same after the addition cryoprotectants.en
dc.format(2012) 104-104
dc.formatapplication/pdf
dc.languageen
dc.publisherBelgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsopenAccess
dc.sourceJoint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstractsen
dc.subjectcryoprotectants
dc.subjectpoly(ε-caprolactone)
dc.subjectfreeze-drying
dc.titleEffects of different cryoprotectants on morphology of lyophilized poly(ε-caprolactone) micro and nanospheresen
dc.typeconferenceObject
dc.rights.licenseBY-NC-ND
dcterms.abstractФилипич, Метка; Ступар, Петар; Стевановић, Магдалена; Цундрич, Сандра; Ускоковић, Драган; Филиповић, Ненад; Павловић, Владимир Б.; Нунић, Јана;
dc.citation.spage104
dc.citation.epage104
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/21517/528.pdf


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