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Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs

Authorized Users Only
2019
Authors
Janićijević, Željko
Ninkov, Marina
Kataranovski, Milena
Radovanović, Filip
Article (Published version)
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Abstract
Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesi...on of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords:
biocompatibility / diffusion / drug delivery systems / hydrogels / ion exchangers
Source:
Macromolecular Bioscience, 2019, 19, 1800322-
Publisher:
  • Wiley
Projects:
  • Immunomodulatory effects of environmental xenobiotics and biotic factors on the populations of mouse-like rodents (RS-173039)
Note:
  • Peer-reviewed manuscript: http://dais.sanu.ac.rs/123456789/4714
  • Supporting information: http://dais.sanu.ac.rs/handle/123456789/3757

DOI: 10.1002/mabi.201800322

ISSN: 1616-5187 (Print); 1616-5195 (Online)

PubMed: 30548776

WoS: 000458369000009

Scopus: 2-s2.0-85058409832
[ Google Scholar ]
2
URI
http://dais.sanu.ac.rs/123456789/5253
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  • ITN SANU - Opšta kolekcija
Institution
Институт техничких наука САНУ

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