Show simple item record

dc.creatorIgnjatović, Nenad
dc.creatorStevanović, Magdalena
dc.creatorVukomanović, Marija
dc.creatorUskoković, Dragan
dc.date.accessioned2019-02-21T13:29:33Z
dc.date.available2019-02-21T13:29:33Z
dc.date.issued2009
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/4935
dc.description.abstractMethod of homogenous sonochemical principle for obtaining controlled forms of micro/nano particles of desired shapes, size and distribution, and solvent/nonsolvent method for obtaining spherical particles of polymer or polymer/ceramics composites with the encapsulated pharmacologically active agent for the treatment of bone tissue pathology, are methods developed in our laboratory for the production of nano and micro ceramic/polymer or polymer composite systems which can be potentially used as controlled bone drug delivery system. Method of homogenous sonochemical precipitation, by designing synthesis parameters like temperature, frequency, energy and ultrasonic field regime, and by applying appropriate solvents, enables producing desired forms and particle structures. Through this method calcium phosphate systems can be obtained, but also systems where calcium phosphate particles are coated with bioresorbable polymer with immobilized antibiotic. Physicochemical synthesis procedure in solvent/non-solvent method consists of initial dissolve of desired bioresorbable polymers and its homogenization, followed by encapsulation of the desired agents. Already produced pharmaceutically active compounds (ascorbic, folic acid, peroxidase, antibiotics, autologous plasma, etc.) can be encapsulated or different calcium phosphates used as fillers for the defected bone tissue. Micro, submicro and nano sized particles in deagglomeration form, optimal for the advanced application in bone engineering, are obtained through these preparation methods.sr
dc.language.isoensr
dc.publisherFaenza : ISTEC-CNRsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//sr
dc.rightsopenAccesssr
dc.sourceAbastracts / Ceramics, cells and tissues: 12th annual seminar and meetingsr
dc.subjectcontrolled drug deliverysr
dc.subjectsonochemistrysr
dc.subjectcomposite biomaterialssr
dc.subjectbonesr
dc.titleTailored preparation of nano and micro composites as new controlled bone drug delivery systemssr
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractИгњатовић, Ненад; Стевановић, Магдалена; Вукомановић, Марија; Ускоковић, Драган;
dc.citation.spage60
dc.citation.epage60
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/15426/Ignjatovic_12-Ceramics-Cells-Tissues_2009.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record