Tailored preparation of nano and micro composites as new controlled bone drug delivery systems
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Method of homogenous sonochemical principle for obtaining controlled forms of micro/nano particles of desired shapes, size and distribution, and solvent/nonsolvent method for obtaining spherical particles of polymer or polymer/ceramics composites with the encapsulated pharmacologically active agent for the treatment of bone tissue pathology, are methods developed in our laboratory for the production of nano and micro ceramic/polymer or polymer composite systems which can be potentially used as controlled bone drug delivery system. Method of homogenous sonochemical precipitation, by designing synthesis parameters like temperature, frequency, energy and ultrasonic field regime, and by applying appropriate solvents, enables producing desired forms and particle structures. Through this method calcium phosphate systems can be obtained, but also systems where calcium phosphate particles are coated with bioresorbable polymer with immobilized antibiotic. Physicochemical synthesis procedure in ...solvent/non-solvent method consists of initial dissolve of desired bioresorbable polymers and its homogenization, followed by encapsulation of the desired agents. Already produced pharmaceutically active compounds (ascorbic, folic acid, peroxidase, antibiotics, autologous plasma, etc.) can be encapsulated or different calcium phosphates used as fillers for the defected bone tissue. Micro, submicro and nano sized particles in deagglomeration form, optimal for the advanced application in bone engineering, are obtained through these preparation methods.
Keywords:
controlled drug delivery / sonochemistry / composite biomaterials / boneSource:
Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting, 2009, 60-60Publisher:
- Faenza : ISTEC-CNR
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ignjatović, Nenad AU - Stevanović, Magdalena AU - Vukomanović, Marija AU - Uskoković, Dragan PY - 2009 UR - https://dais.sanu.ac.rs/123456789/4935 AB - Method of homogenous sonochemical principle for obtaining controlled forms of micro/nano particles of desired shapes, size and distribution, and solvent/nonsolvent method for obtaining spherical particles of polymer or polymer/ceramics composites with the encapsulated pharmacologically active agent for the treatment of bone tissue pathology, are methods developed in our laboratory for the production of nano and micro ceramic/polymer or polymer composite systems which can be potentially used as controlled bone drug delivery system. Method of homogenous sonochemical precipitation, by designing synthesis parameters like temperature, frequency, energy and ultrasonic field regime, and by applying appropriate solvents, enables producing desired forms and particle structures. Through this method calcium phosphate systems can be obtained, but also systems where calcium phosphate particles are coated with bioresorbable polymer with immobilized antibiotic. Physicochemical synthesis procedure in solvent/non-solvent method consists of initial dissolve of desired bioresorbable polymers and its homogenization, followed by encapsulation of the desired agents. Already produced pharmaceutically active compounds (ascorbic, folic acid, peroxidase, antibiotics, autologous plasma, etc.) can be encapsulated or different calcium phosphates used as fillers for the defected bone tissue. Micro, submicro and nano sized particles in deagglomeration form, optimal for the advanced application in bone engineering, are obtained through these preparation methods. PB - Faenza : ISTEC-CNR C3 - Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting T1 - Tailored preparation of nano and micro composites as new controlled bone drug delivery systems SP - 60 EP - 60 UR - https://hdl.handle.net/21.15107/rcub_dais_4935 ER -
@conference{ author = "Ignjatović, Nenad and Stevanović, Magdalena and Vukomanović, Marija and Uskoković, Dragan", year = "2009", abstract = "Method of homogenous sonochemical principle for obtaining controlled forms of micro/nano particles of desired shapes, size and distribution, and solvent/nonsolvent method for obtaining spherical particles of polymer or polymer/ceramics composites with the encapsulated pharmacologically active agent for the treatment of bone tissue pathology, are methods developed in our laboratory for the production of nano and micro ceramic/polymer or polymer composite systems which can be potentially used as controlled bone drug delivery system. Method of homogenous sonochemical precipitation, by designing synthesis parameters like temperature, frequency, energy and ultrasonic field regime, and by applying appropriate solvents, enables producing desired forms and particle structures. Through this method calcium phosphate systems can be obtained, but also systems where calcium phosphate particles are coated with bioresorbable polymer with immobilized antibiotic. Physicochemical synthesis procedure in solvent/non-solvent method consists of initial dissolve of desired bioresorbable polymers and its homogenization, followed by encapsulation of the desired agents. Already produced pharmaceutically active compounds (ascorbic, folic acid, peroxidase, antibiotics, autologous plasma, etc.) can be encapsulated or different calcium phosphates used as fillers for the defected bone tissue. Micro, submicro and nano sized particles in deagglomeration form, optimal for the advanced application in bone engineering, are obtained through these preparation methods.", publisher = "Faenza : ISTEC-CNR", journal = "Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting", title = "Tailored preparation of nano and micro composites as new controlled bone drug delivery systems", pages = "60-60", url = "https://hdl.handle.net/21.15107/rcub_dais_4935" }
Ignjatović, N., Stevanović, M., Vukomanović, M.,& Uskoković, D.. (2009). Tailored preparation of nano and micro composites as new controlled bone drug delivery systems. in Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting Faenza : ISTEC-CNR., 60-60. https://hdl.handle.net/21.15107/rcub_dais_4935
Ignjatović N, Stevanović M, Vukomanović M, Uskoković D. Tailored preparation of nano and micro composites as new controlled bone drug delivery systems. in Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting. 2009;:60-60. https://hdl.handle.net/21.15107/rcub_dais_4935 .
Ignjatović, Nenad, Stevanović, Magdalena, Vukomanović, Marija, Uskoković, Dragan, "Tailored preparation of nano and micro composites as new controlled bone drug delivery systems" in Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting (2009):60-60, https://hdl.handle.net/21.15107/rcub_dais_4935 .