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dc.creatorVukomanović, Marija
dc.creatorŠarčev, Igor
dc.creatorPetronijević, B.
dc.creatorŠkapin, Srečo Davor
dc.creatorIgnjatović, Nenad
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2012
dc.identifier.issn0927-7765
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/490
dc.description.abstractThe surface properties of PLGA/HAp core–shell nanoparticles loaded with clindamycin obtained by an ultrasonic processing method and their changes under the simulated physiological conditions during the degradation process (when the morphology is changed starting from the nanospheres, over micrometer-sized plate-like films to a porous network) were investigated. The dynamic change of the surface properties of this material obtained in a water environment showed an increase of the surface area (up to 70 m2/g) and an improved wettability (estimated water contact angle was in the range between 40° and 60°) suggesting the possibility for its good interaction with cells. The in vitro tests are in a good correlation with this hypothesis, showing a high level of cytocompatibility of the material with the mouse L929 and human lung MRC-5 fibroblasts. The fibroblasts were able to achieve the contact with the material's surface and to attach onto it. The significance of HAp, as the bioceramic phase within the PLGA/HAp core–shell nanoparticles, may be brought into relationship with its role in improving the surface properties of PLGA/HAp obtained during the degradation process. These properties are closely related to the bioactivity and biocompatibility of this material, which are highly relevant for its biomedical application.en
dc.format91 (2012) 144-153
dc.languageen
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsrestrictedAccess
dc.sourceColloids and Surfaces B: Biointerfacesen
dc.subjectPLGA and HAp
dc.subjectantibiotics
dc.subjectdegradation
dc.subjectsurface properties
dc.subjectcytotoxicity
dc.titlePoly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 4: A change of the surface properties during degradation process and the corresponding in vitro cellular responseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractШкапин, Сречо Давор; Ускоковић, Драган; Игњатовић, Ненад; Петронијевић, Б.; Шарчев, Игор; Вукомановић, Марија;
dc.citation.spage144
dc.citation.epage153
dc.identifier.wos000300471200020
dc.identifier.doi10.1016/j.colsurfb.2011.10.049
dc.identifier.scopus2-s2.0-84855187240
dc.type.versionpublishedVersion


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