Show simple item record

dc.creatorFilipović, Nenad
dc.creatorDigilio, Giuseppe
dc.creatorCatanzaro, Valeria
dc.creatorCapuana, Federico
dc.creatorCutrin, Juan C.
dc.creatorCarniato, Fabio
dc.creatorPorta, Stefano
dc.creatorGrange, Cristina
dc.creatorStevanović, Magdalena
dc.date.accessioned2018-12-29T16:15:20Z
dc.date.available2018-12-29T16:15:20Z
dc.date.issued2018
dc.identifier.isbn978-86-80321-34-9
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/4721
dc.description.abstractCell therapy is promising strategy that has attracted a lot of attention recently regarding regeneration of diverse tissues and treatment of various pathological conditions. Despite its great potential, several issues still need to be addressed. Among them administration route and dose, microenvironment conditions and host immune response are recognized as a major causes which lead to cells transplantation failure. In this work it is presented novel microstructural system based on biodegradable polymer poly(lactide-co-glycolide) (PLGA) and combination of biocompatible polyvinyl alcohol (PVA) and chitosan, as a scaffold for human mesenchymal stem cells (hMSCs) growth. The obtained microparticles with diameter 200-600 μm showed full biocompatibility with human hMSCs. Besides serving as a solid support, polymeric particles provided controlled release of contrast agent - gadolinium fluoride nanoparticles (Gd-NP) up to 5 weeks. The release of Gd-NP is enhanced by acidic conditions. Magnetic Resonance Imaging (MRI) of the samples embedded in 1% agar showed that contrast enhancement in T1-weighted (T1w) MR images is influenced by the amount of released Gd-NP. Based on these preliminary results, presented theranostic system could be considered for cells grafting.sr
dc.language.isoensr
dc.publisherBelgrade : Institute of Technical Sciences of SASAsr
dc.relationItalian Ministry of Foreign Affairs and International Cooperation (MAECI) within the collaboration framework between Italy and the Republic of Serbia (project PGR02952, call “Grande Rilevanza”)sr
dc.relationItalian Ministry of University and Education, PRIN-2010 n. 2010B5B2NLsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//sr
dc.rightsopenAccesssr
dc.sourceProgram and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbiasr
dc.subjectcell therapysr
dc.subjectbiodegradable microparticlessr
dc.subjectscaffoldssr
dc.subjectpoly(lactide-co-glycolidesr
dc.subjectPLGAsr
dc.subjectpolyvinyl alcoholsr
dc.subjectPVAsr
dc.subjectchitosansr
dc.subjectmesenchymal stem cellssr
dc.subjecthMSCssr
dc.subjectMagnetic Resonance Imagingsr
dc.titleBiodegradable microparticles as scaffolds for cell therapysr
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractЦарниато, Фабио; Цутрин, Јуан Ц.; Филиповић, Ненад; Стевановић, Магдалена; Дигилио, Гиусеппе; Цатанзаро, Валериа; Гранге, Цристина; Порта, Стефано; Цапуана, Федерицо;
dc.citation.spage7
dc.citation.epage7
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/14739/Filipovic-17YRC2018.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record