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dc.creatorJanićijević, Željko
dc.creatorVujčić, Ivica T.
dc.creatorVujisić, Miloš Lj.
dc.creatorRadovanović, Filip
dc.date.accessioned2018-12-29T16:15:07Z
dc.date.available2018-12-29T16:15:07Z
dc.date.issued2018
dc.identifier.isbn978-86-80321-34-9
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/4720
dc.description.abstractComposite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants.sr
dc.language.isoensr
dc.publisherBelgrade : Institute of Technical Sciences of SASAsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS//sr
dc.rightsopenAccesssr
dc.sourceProgram and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbiasr
dc.subjectpoly(lactic-co-glycolic acid)/poly(acrylic acid)sr
dc.subjectPLGA/PAAsr
dc.subjectcomposite implantssr
dc.subjectcontrolled drug delivery systemssr
dc.subjectgamma irradiationsr
dc.subjectUV irradiationsr
dc.titleComparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiationsr
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractРадовановић, Филип; Јанићијевић, Жељко; Вујчић, Ивица Т.; Вујисић, Милош Љ.;
dc.citation.spage28
dc.citation.epage28
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/14746/Janicijevic-17YRC2018-4.pdf


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