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dc.creatorJanićijević, Željko
dc.creatorNinkov, Marina
dc.creatorKataranovski, Milena
dc.creatorRadovanović, Filip
dc.date.accessioned2018-12-28T21:02:05Z
dc.date.available2019-12-13
dc.date.issued2019
dc.identifier.issn1616-5187 (Print)
dc.identifier.issn1616-5195 (Online)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/4714
dc.description.abstractPoly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173039/RS//
dc.rightsembargoedAccess
dc.sourceMacromolecular Bioscience
dc.subjectbiocompatibility
dc.subjectdiffusion
dc.subjectdrug delivery systems
dc.subjecthydrogels
dc.subjection exchangers
dc.titlePoly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractНинков, Марина; Јанићијевић, Жељко; Радовановић, Филип; Катарановски, Милена;
dc.citation.spage1800322
dc.citation.volume19
dc.identifier.wos000458369000009
dc.identifier.doi10.1002/mabi.201800322
dc.identifier.pmid30548776
dc.identifier.scopus2-s2.0-85058409832
dc.description.otherThis is the peer-reviewed version of the article: Janićijević, Ž., Ninkov, M., Kataranovski, M., Radovanović, F., 2018. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs 1800322. [https://doi.org/10.1002/mabi.201800322]
dc.description.otherSupporting information: [http://dais.sanu.ac.rs/handle/123456789/3757]
dc.type.versionacceptedVersion


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