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dc.creatorKrueger, Eddy
dc.creatorMagri, L. M. S.
dc.creatorBotelho, A. S.
dc.creatorBach, F. S.
dc.creatorRebellato, C. L. K.
dc.creatorFracaro, L.
dc.creatorFragoso, F. Y. I.
dc.creatorVillanova, J. A.
dc.creatorBrofman, P. R. S.
dc.creatorPopović Maneski, Lana
dc.date.accessioned2018-12-18T10:29:48Z
dc.date.available2019-12-04T10:26:17Z
dc.date.issued2019
dc.identifier.issn0304-3940
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0304394018308498
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/4596
dc.description.abstractThe application of low-intensity electrical stimulation (LIES) to neural tissue increases neurochemical factors responsible for regeneration as nerve growth factor. Stem cell (SC) therapy for patients with Spinal cord injury (SCI) promote some increase functional improvement.ObjectiveInvestigate the electromyographic response in paraplegic dogs undergoing LIES and SC transplantation.Methods27 dogs paraplegics with SCI were divided into three groups with different types of therapy. GADSC: two SC transplants (n = 9); GLIES: LIES (n = 8); GCOMB: two SC transplants and LIES (n = 10). Adipose derived mesenchymal stem cells (ADSCs) were transplanted by lumbar puncture in the amount of 1.2 × 106 cells/50 μL. Acupuncture needles positioned in the interspinous space were used for stimulation. The electrical stimulation was applied with a mean voltage ∼30 mV and four consecutive modulated frequencies (5 Hz, 10 Hz, 15 Hz and 20 Hz) within 5 min each. The patients motor performance was evaluated before (Pre) the procedure and after 30 (Post30) and 60 (Post60) days, from electromyography root mean square (EMGRMS) registered with subcutaneous electrodes in the vastus lateralis muscle, while the animals were in quadrupedal position.ResultsAll three groups showed a significant intra-group increase of EMGRMS (Pre vs. Post30 or Pre vs. Post60). However, there were no statistically significant differences between Post30 and Post60. The inter-group test (GADSC X GLIES X GCOMB) did not present significance when compared the instants Pre (p = 0.34), Post30 (p = 0.78) and Post60 (p = 0.64).ConclusionSome dogs recovered motor activity, expressed by the EMGRMS, in all groups, in pre vs. post (30 or 60 days) comparisons.
dc.publisherElsevier
dc.relationCoordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001
dc.relationCNPq - National Council for Scientific and Technological Development for financial support process n. 151210/2018-7
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/44008/RS//
dc.rightsembargoedAccess
dc.sourceNeuroscience Letters
dc.subjectAdipose derived mesenchymal stem cells
dc.subjectelectrotherapy
dc.subjectneural rehabilitation
dc.subjectspinal cord injury
dc.titleEffects of low-intensity electrical stimulation and adipose derived stem cells transplantation on the time-domain analysis-based electromyographic signals in dogs with SCI
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractРебеллато, Ц. Л. К.; Ботелхо, A. С.; Фрацаро, Л.; Фрагосо, Ф. Y. И.; Вилланова, Ј. A.; Бацх, Ф. С.; Поповић-Манески, Лана; Магри, Л. М. С.; Круегер, Еддy; Брофман, П. Р. С.;
dc.citation.spage38
dc.citation.epage45
dc.citation.volume696
dc.identifier.wos000463125800007
dc.identifier.doi10.1016/j.neulet.2018.12.004
dc.identifier.scopus2-s2.0-85058535579
dc.description.otherThis is the peer-reviewed version of the article: Krueger, E., Magri, L.M.S., Botelho, A.S., Bach, F.S., Rebellato, C.L.K., Fracaro, L., Fragoso, F.Y.I., Villanova, J.A., Brofman, P.R.S., Popović-Maneski, L., 2019. Effects of low-intensity electrical stimulation and adipose derived stem cells transplantation on the time-domain analysis-based electromyographic signals in dogs with SCI. Neuroscience Letters 696, 38–45. [https://doi.org/10.1016/j.neulet.2018.12.004]
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