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dc.creatorFilipović, Nenad
dc.creatorStevanović, Magdalena
dc.creatorStupar, Petar
dc.creatorPetković, Jana
dc.creatorFilipič, Metka
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2012
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/456
dc.description.abstractPoly (ε-caprolactone) (PCL) is a widely investigated bioresorbable polymer and it has been extensively used in numerous biomaterials applications especially in tissue engineering and drug delivery systems. Freeze-dried particles of poly (ε-caprolactone), with different morphological characteristics (spherical or cube in shape), were prepared by physicochemical method with solvent/non-solvent systems and by using the different types of cryoprotectants. Natural polymer poly (L-glutamic acid) (PGA) as well as disaccharide, saccharose, were used as cryoprotectant i.e. substance that is used to protect particles from freezing damage (damage due to ice formation). PGA has dual role in the synthesis; besides as cryoprotectant, it acts as stabilizer of the particles i.e. to prevent their agglomeration. The samples were characterized by Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). The biocompatibility of the samples was examined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The formation of intracellular reactive oxygen species was measured spectrophotometrically using a fluorescent probe.en
dc.format(2012) 124-124
dc.formatapplication/pdf
dc.languageen
dc.publisherBelgrade : Materials Research Society of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsclosedAccess
dc.sourceThe Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstractsen
dc.subjectpoly (ε-caprolactone)
dc.subjectbioresorbable polymers
dc.subjectpoly (L-glutamic acid)
dc.subjectfreeze-drying
dc.titleFreeze-drying method to produce a range of PCL particles with tailored morphological propertiesen
dc.typeconferenceObject
dc.rights.licenseBY-NC-ND
dcterms.abstractФилиповић, Ненад; Ускоковић, Драган; Филипич, Метка; Петковић, Јана; Ступар, Петар; Стевановић, Магдалена;
dc.citation.spage124
dc.citation.epage124
dc.type.versionpublishedVersion


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