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dc.creatorMančić, Lidija
dc.creatorĐukić Vuković, Aleksandra
dc.creatorDinić, Ivana
dc.creatorNikolić, Marko G.
dc.creatorRabasović, Mihailo D.
dc.creatorKrmpot, Aleksandar
dc.creatorCosta, Antonio Mario Leal Martins
dc.creatorTrišić, Dijana
dc.creatorLazarević, Miloš
dc.creatorMojović, Ljiljana
dc.creatorMilošević, Olivera
dc.date.accessioned2018-10-29T13:27:22Z
dc.date.available2020-05-31
dc.date.issued2018
dc.identifier.issn0928-4931
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/4083
dc.description.abstractLanthanide-doped fluoride up-converting nanoparticles (UCNPs) represent the new class of imaging contrast agents which hold great potential for overcoming existing problems associated with traditionally used dyes, proteins and quantum dots. In this study, a new kind of hybrid NaYF4:Yb,Er/PLGA nanoparticles for efficient biolabeling were prepared through one-pot solvothermal synthesis route. Morphological and structural characteristics of the as-designed particles were obtained using X-ray powder diffraction (XRPD), scanning and transmission electron microscopy (SEM/TEM), energy dispersive spectroscopy (EDS), Fourier transform infrared (FTIR) and photoluminescence (PL) spectroscopy, while their cytotoxicity as well as up-conversion (UC) labeling capability were tested in vitro toward human gingival cells (HGC) and oral squamous cell carcinoma (OSCC). The results revealed coexistence of the cubic (Fm-3m) and hexagonal (P63/m) phase in spherical and irregularly shaped nanoparticles, respectively. PLGA [Poly(lactic-co-glycolic acid)] ligands attached at the surface of UCNPs particles provide their enhanced cellular uptake and enable high-quality cells imaging through a near-infrared (NIR) laser scanning microscopy (λex = 980 nm). Moreover, the fact that NaYF4:Yb,Er/PLGA UCNPs show low cytotoxicity against HGC over the whole concentration range (10–50 μg/mL) while a dose dependent viability of OSCC is obtained indicates that these might be a promising candidates for targeted cancer cell therapy. © 2018 Elsevier B.V.
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45016/RS//
dc.rightsembargoedAccess
dc.sourceMaterials Science and Engineering C
dc.subjectPLGA
dc.subjectbioimaging
dc.subjectcancer cell
dc.subjecthuman gingival cell
dc.subjectNaYF4:Yb,Er
dc.subjectupconversion nanoparticles
dc.titleNIR photo-driven upconversion in NaYF4:Yb,Er/PLGA particles for in vitro bioimaging of cancer cells
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractРабасовић, Михаило Д.; Цоста, Aнтонио Марио Леал Мартинс; Тришић, Дијана; Лазаревић, Милош; Мојовић, Љиљана; Милошевић, Оливера; Николић, Марко Г.; Манчић, Лидија; Динић, Ивана; Крмпот, Aлександар Ј.; Ђукић-Вуковић, Aлександра;
dc.citation.spage597
dc.citation.epage605
dc.citation.volume91
dc.identifier.wos000442192000061
dc.identifier.doi10.1016/j.msec.2018.05.081
dc.identifier.scopus2-s2.0-85047855276
dc.description.otherThis is the peer reviewed version of the following article: Mancic, L., A. Djukic-Vukovic, I. Dinic, M.G. Nikolic, M.D. Rabasovic, A.J. Krmpot, A.M.L.M. Costa, et al. 2018. “NIR Photo-Driven Upconversion in NaYF4:Yb,Er/PLGA Particles for in Vitro Bioimaging of Cancer Cells.” Materials Science and Engineering C 91: 597–605. [https://doi.org/10.1016/j.msec.2018.05.081]
dc.description.otherPublished version: [http://dais.sanu.ac.rs/123456789/3693]
dc.description.otherSupporting information: [http://dais.sanu.ac.rs/handle/123456789/5978]
dc.type.versionacceptedVersion


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