Improvement of solubility of disperse materials by the means of the mechanochemical treatment

Abstract

The solubility of drug is very important factor that determines its applicability, since solubility may act as rate-limiting step in absorption and therefore may affect the bioavailability of the drug. More than 40% of potential drug products suffer from poor water solubility which frequently results in potentially important products not reaching the market or not achieving their full potential. In this work, an effort will be invested in order to improve solubility of verapamil hydrochloride by the means of mechanochemical treatment. Influence of mechanochemical parameters and surfactants on the physicochemical properties will be examined using a XRD, FE SEM technique and Malvern’s Master Sizer instrument for particle size distribution. Finally, solubility of verapamil hydrochloride will be correlated with the particle size, structural and morphological characteristics of the drug via UV-VIS Cintra 101 spectrometer.