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dc.creatorMakević, Sonja
dc.creatorStanković, Ana
dc.creatorUskoković, Dragan
dc.date.accessioned2018-07-31T12:38:10Z
dc.date.available2018-07-31T12:38:10Z
dc.date.issued2010
dc.identifier.isbn9788680321189
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3593
dc.description.abstractThe solubility of drug is very important factor that determines its applicability, since solubility may act as rate-limiting step in absorption and therefore may affect the bioavailability of the drug. More than 40% of potential drug products suffer from poor water solubility which frequently results in potentially important products not reaching the market or not achieving their full potential. In this work, an effort will be invested in order to improve solubility of verapamil hydrochloride by the means of mechanochemical treatment. Influence of mechanochemical parameters and surfactants on the physicochemical properties will be examined using a XRD, FE SEM technique and Malvern’s Master Sizer instrument for particle size distribution. Finally, solubility of verapamil hydrochloride will be correlated with the particle size, structural and morphological characteristics of the drug via UV-VIS Cintra 101 spectrometer.sr
dc.language.isoensr
dc.publisherBelgrade : Institute of Technical Sciences of SASAsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//sr
dc.rightsopenAccesssr
dc.sourceProgramme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010sr
dc.subjectmechanochemical treatmentsr
dc.subjectsolubilitysr
dc.subjectverapamil hydrochloridesr
dc.titleImprovement of solubility of disperse materials by the means of the mechanochemical treatmentsr
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractМакевић, Соња; Станковић, Aна; Ускоковић, Драган;
dc.citation.spage92
dc.citation.epage92
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/3593/Makevic_YUCOMAT2010_92.pdf


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