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dc.creatorStevanović, Magdalena
dc.creatorRadulović, Aleksandra
dc.creatorJordović, Branka
dc.creatorUskoković, Dragan
dc.date.accessioned2018-07-29T18:52:29Z
dc.date.available2018-07-29T18:52:29Z
dc.date.issued2008
dc.identifier.issn1550-7033
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3574
dc.description.abstractBiodegradable polymers have become the materials of choice for a variety of biomedical applications. In particular, poly(DL-lactide-co-glycolide) nanoparticles have been studied as a material for drug delivery with the controlled release. In this paper we are describing a simple method for obtaining the system for targeted and controlled delivery of folic acid in the body. Folic acid was encapsulated into the polymer matrix by means of homogenization of aqueous and organic phases. Concentration of folic acid in water was varied in order to obtain nanoparticles with different ratios of poly(DL-lactide-co-glycolide) and folic acid. The particles were obtained by physicochemical solvent/non-solvent method with polyvinyl pyrrolidone as a surfactant. The obtained particles are non-agglomerated, uniform and with particles size in the nanometer range. The samples were characterized using Infrared Spectroscopy (IR), Ultraviolet Spectroscopy (UV), Zeta potential measurements, Scanning Electron Microscopy (SEM) and Stereological analysis. Copyright © 2008 American Scientific Publishers All rights reserved.
dc.publisherAmerican Scientific Publishers
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Biomedical Nanotechnology
dc.subjectdrug delivery
dc.subjectfolic acid
dc.subjectIR
dc.subjectnanoparticles
dc.subjectpoly(DL-lactide-co-glycolide)
dc.subjectSEM
dc.subjectstereological analysis
dc.subjectUV-Vis
dc.subjectzeta potential measurements
dc.titlePoly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractРадуловић, A.; Стевановић, Магдалена; Јордовић, Бранка; Ускоковић, Драган;
dc.citation.spage349
dc.citation.epage358
dc.citation.volume4
dc.citation.issue3
dc.identifier.wos000260776500014
dc.identifier.doi10.1166/jbn.2008.321
dc.identifier.scopus2-s2.0-58149196373
dc.type.versionpublishedVersion


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