Nano-bioresorbable polymer spheres as carriers for transdermal delivery of ketoprofene
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The transdermal delivery system provides a highly efficient, safe, and easy to use method for delivering active ingredients and other compounds to the body through intact skin, thereby offering many other advantages over the traditional dosage forms. Ketoprofen is a poorly watersoluble non-steroidal antiinflammatory drug and widely used for the acute and long-term treatment of rheumatoid arthritis and associated diseases. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new nanoparticulate system for drug delivery of ketoprofene suitable for transdermal applications. Multi-scale design of a transdermal drug delivery system, from the molecular or nano scale through the macroscopic scale, was analyzed. The obtained nano particles contain ketoprofene-loaded spheres of poly(D,L-lactide acid) (PDLLA). Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning... electron microscopy (FESEM), high performance liquid chromatography (HPLC) and particle sized distribution (PSD) methods. XRD and FT-IR analyses confirmed that the ketoprofene is immobilized into PDLLA. The encapsulation of ketoprofen into the PDLLA nanoparticles was highly accomplished and the drug loading efficiency was 75%. The observed average particle dimension (d50) of ketoprofene-loaded nano particles was 63 nm.
Keywords:
transdermal drug delivery / ketoprofen / PDLLASource:
Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010, 2010, 61-61Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-MESTD-MPN2006-2010-142006)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ignjatović, Nenad AU - Vučen, Sonja AU - Vuleta, Gordana AU - Uskoković, Dragan PY - 2010 UR - https://dais.sanu.ac.rs/123456789/3554 AB - The transdermal delivery system provides a highly efficient, safe, and easy to use method for delivering active ingredients and other compounds to the body through intact skin, thereby offering many other advantages over the traditional dosage forms. Ketoprofen is a poorly watersoluble non-steroidal antiinflammatory drug and widely used for the acute and long-term treatment of rheumatoid arthritis and associated diseases. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new nanoparticulate system for drug delivery of ketoprofene suitable for transdermal applications. Multi-scale design of a transdermal drug delivery system, from the molecular or nano scale through the macroscopic scale, was analyzed. The obtained nano particles contain ketoprofene-loaded spheres of poly(D,L-lactide acid) (PDLLA). Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), high performance liquid chromatography (HPLC) and particle sized distribution (PSD) methods. XRD and FT-IR analyses confirmed that the ketoprofene is immobilized into PDLLA. The encapsulation of ketoprofen into the PDLLA nanoparticles was highly accomplished and the drug loading efficiency was 75%. The observed average particle dimension (d50) of ketoprofene-loaded nano particles was 63 nm. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 T1 - Nano-bioresorbable polymer spheres as carriers for transdermal delivery of ketoprofene SP - 61 EP - 61 UR - https://hdl.handle.net/21.15107/rcub_dais_3554 ER -
@conference{ author = "Ignjatović, Nenad and Vučen, Sonja and Vuleta, Gordana and Uskoković, Dragan", year = "2010", abstract = "The transdermal delivery system provides a highly efficient, safe, and easy to use method for delivering active ingredients and other compounds to the body through intact skin, thereby offering many other advantages over the traditional dosage forms. Ketoprofen is a poorly watersoluble non-steroidal antiinflammatory drug and widely used for the acute and long-term treatment of rheumatoid arthritis and associated diseases. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new nanoparticulate system for drug delivery of ketoprofene suitable for transdermal applications. Multi-scale design of a transdermal drug delivery system, from the molecular or nano scale through the macroscopic scale, was analyzed. The obtained nano particles contain ketoprofene-loaded spheres of poly(D,L-lactide acid) (PDLLA). Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), high performance liquid chromatography (HPLC) and particle sized distribution (PSD) methods. XRD and FT-IR analyses confirmed that the ketoprofene is immobilized into PDLLA. The encapsulation of ketoprofen into the PDLLA nanoparticles was highly accomplished and the drug loading efficiency was 75%. The observed average particle dimension (d50) of ketoprofene-loaded nano particles was 63 nm.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010", title = "Nano-bioresorbable polymer spheres as carriers for transdermal delivery of ketoprofene", pages = "61-61", url = "https://hdl.handle.net/21.15107/rcub_dais_3554" }
Ignjatović, N., Vučen, S., Vuleta, G.,& Uskoković, D.. (2010). Nano-bioresorbable polymer spheres as carriers for transdermal delivery of ketoprofene. in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 Belgrade : Institute of Technical Sciences of SASA., 61-61. https://hdl.handle.net/21.15107/rcub_dais_3554
Ignjatović N, Vučen S, Vuleta G, Uskoković D. Nano-bioresorbable polymer spheres as carriers for transdermal delivery of ketoprofene. in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010. 2010;:61-61. https://hdl.handle.net/21.15107/rcub_dais_3554 .
Ignjatović, Nenad, Vučen, Sonja, Vuleta, Gordana, Uskoković, Dragan, "Nano-bioresorbable polymer spheres as carriers for transdermal delivery of ketoprofene" in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 (2010):61-61, https://hdl.handle.net/21.15107/rcub_dais_3554 .