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dc.creatorIgnjatović, Nenad
dc.creatorAjduković, Zorica
dc.creatorRajković, Jelena
dc.creatorNajman, Stevo
dc.creatorMihailović, Dragan
dc.creatorUskoković, Dragan
dc.date.accessioned2018-07-25T13:34:16Z
dc.date.available2018-07-25T13:34:16Z
dc.date.issued2015
dc.identifier.issn1672-6529
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3547
dc.description.abstractHydroxyapatite (HAp) is an extensively studied material with known biocompatible and osteoconductive properties in bone tissue reconstruction. The improvement of the osteogenetic potential of HAp has been tested through modification of its structure, by replacing Ca2+ ions with Co2+ ions. In our study, we comparatively analyze the osteogenetic potential of the synthesized HAp and Co2+-substituted HAp (HAp/Co) designed on the nano-scale with the aim of specifically stimulating osteogenesis in vivo. We present a quantitative study of the microscopic organization and structure of the newly formed tissue in a bone defect after 12 weeks and 24 weeks. A quantitative analysis of the calcium, magnesium and phosphorus content in the defect and its close environment was used to determine the deposition of minerals after bone reconstruction. The defect reconstructed with HAp/Co nanoparticles (Co2+ content 12 wt%) was filled with a new tissue matrix composed of dense collagen fibers containing centers of mineralization after 24 weeks. The mineral deposition rate was also higher when the defect was reconstructed with HAp/Co than when it was filled with pure HAp. A histological analysis confirmed that the alveolar bone, in which osteoporosis-induced defects were repaired using HAp/Co nanoparticles, was recuperated. © 2015 Jilin University.
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Bionic Engineering
dc.subjectadvanced osteogenesis
dc.subjectcobalt-substituted hydroxyapatite
dc.subjecthistomorphometry
dc.subjectnanoparticles
dc.titleEnhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractИгњатовић, Ненад; Aјдуковић, Зорица; Рајковић, Јелена; Најман, Стево; Михаиловић, Драган; Ускоковић, Драган;
dc.citation.spage604
dc.citation.epage612
dc.citation.volume12
dc.citation.issue4
dc.identifier.wos000363494700009
dc.identifier.doi10.1016/S1672-6529(14)60150-5
dc.identifier.scopus2-s2.0-84944556234
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/3547/Ignjatovic_2015_Journal-of-Bionic-Engineering_12_604.pdf


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