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dc.creatorFrantlović, Miloš
dc.creatorJokić, Ivana
dc.creatorĐurić, Zoran G.
dc.creatorRadulović, Katarina
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2013
dc.identifier.issn0925-4005
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/350
dc.description.abstractWe analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, considering adsorption–desorption and mass transfer processes of two molecular species which compete for binding to the same probe molecules immobilized on the sensing surface. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum, and also of their combined effect. The dependences of the fluctuations on association and dissociation rate constants of both adsorbing species, their concentrations, molecular masses and mass transfer coefficients and also on the density of capturing probes can be examined by using the presented model. The model is applicable for biosensors in which the spatial distribution of adsorbates concentrations in the reaction chamber can be approximated using the two-compartment model. The theory provides a more realistic estimation of the biosensors’ limiting performance, and is useful for their improvement.en
dc.format189 (2013) 71-79
dc.languageen
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS//
dc.relationSerbian Academy of Sciences and Arts, Project F-150
dc.rightsrestrictedAccess
dc.sourceSensors and Actuators B: Chemicalen
dc.subjectbiosensors
dc.subjectcompetitive binding
dc.subjectadsorption–desorption
dc.subjectmass transfer
dc.subjectfluctuations
dc.titleAnalysis of the competitive adsorption and mass transfer influence on equilibrium mass fluctuations in affinity-based biosensorsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂурић, Зоран; Јокић, Ивана; Радуловић, Катарина; Франтловић, Милош;
dc.citation.spage71
dc.citation.epage79
dc.citation.volume189
dc.identifier.wos000326346300011
dc.identifier.doi10.1016/j.snb.2012.12.080
dc.identifier.scopus2-s2.0-84887061320
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/350/paper611-347.pdf


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