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Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry
dc.creator | Vuković, Gorica | |
dc.creator | Lazić, Sanja | |
dc.creator | Šunjka, Dragana | |
dc.creator | Bursić, Vojislava | |
dc.creator | Šarčev, Ivan | |
dc.creator | Vukomanović, Marija | |
dc.creator | Ignjatović, Nenad | |
dc.creator | Uskoković, Dragan | |
dc.date.accessioned | 2018-07-06T13:17:09Z | |
dc.date.available | 2018-07-06T13:17:09Z | |
dc.date.issued | 2010 | |
dc.identifier.isbn | 9788680321264 | |
dc.identifier.uri | https://dais.sanu.ac.rs/123456789/3453 | |
dc.description.abstract | Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory. | en |
dc.language.iso | en | sr |
dc.publisher | Belgrade : Institute of Technical Sciences of SASA | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia | sr |
dc.subject | LC-MS/MS | sr |
dc.subject | clindamycin | sr |
dc.subject | poly(D,L-lactide-co-glycolide) | en |
dc.subject | hydroxyapatite | sr |
dc.subject | core-shell nanoparticles | sr |
dc.title | Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry | en |
dc.type | conferenceObject | sr |
dc.rights.license | BY-NC-ND | sr |
dcterms.abstract | Шарчев, Иван; Вукомановић, Марија; Игњатовић, Ненад; Ускоковић, Драган; Лазић, Сања; Шуњка, Драгана; Бурсић, Војислава; Вуковић, Горица; | |
dc.citation.spage | 19 | |
dc.citation.epage | 19 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://dais.sanu.ac.rs/bitstream/id/11073/Vukovic_9KMI_2010_IV-8.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_dais_3453 |