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dc.creatorIgnjatović, Nenad
dc.creatorAjduković, Zorica
dc.creatorSavić, Vojin. P.
dc.creatorUskoković, Dragan
dc.date.accessioned2018-06-22T18:44:34Z
dc.date.available2018-06-22T18:44:34Z
dc.date.issued2010
dc.identifier.issn1552-4973
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3419
dc.description.abstractIn this article, synthesis and application of calcium phosphate/poly-DL- lactide-co-glycolide (CP/PLGA) composite biomaterial in particulate form, in which each CP granule/particle is coated with PLGA, are described. Two types of the particulate material having different particle sizes were synthesized: one with an average particle diameter between 150 and 250 μm (micron-sized particles, MPs) and the other with an average particle diameter smaller than 50 nm (nanoparticles, NPs). A comparative in vivo analysis was done by reconstructing defects in osteoporotic alveolar bones using both composites. The material, CP granules/particles covered with polymer, was characterized using X-ray structural analysis, scanning electron microscopy, and atomic force microscopy. Changes in reparatory functions of tissues affected by osteoporosis were examined in mice in vivo, using these two kinds of composite materials, with and without autologous plasma. Having defined the target segment, histomorphometric parameters - bone area fraction, area, and mean density - were determined. The best results in the regeneration and recuperation of alveolar bone damaged by osteoporosis were achieved with the implantation of a mixture of nanoparticulate CP/PLGA composite and autologous plasma. After the implantation of microparticulate CP/PLGA, in the form of granules, mixed with autologous plasma, into an artificial defect in alveolar bone, new bone formation was also observed, although its formation rate was slower. © 2010 Wiley Periodicals, Inc.
dc.publisherHoboken, NJ : John Wiley & Sons
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145068/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Biomedical Materials Research - Part B Applied Biomaterials
dc.subjectnanoparticles
dc.subjectmicroparticles
dc.subjectalveolar bone
dc.subjectautologous plasma
dc.subjectCalcium phosphate/poly-DL-lactide-co-glycolide (CP/PLGA)
dc.titleSize effect of calcium phosphate coated with poly-DL-lactideco-glycolide on healing processes in bone reconstruction
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractИгњатовић, Ненад; Ускоковић, Драган; Савић, В. П.; Aјдуковић, Зорица;
dc.citation.spage108
dc.citation.epage117
dc.citation.volume94
dc.citation.issue1
dc.identifier.doi10.1002/jbm.b.31630
dc.identifier.scopus2-s2.0-77954136401
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/3419/Ignjatovic-N.L._Journal-of-Biomedical-Materials-Research-Part-B-Applied-Biomaterials_94_2010_108_117.pdf


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