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Multifunkcionalni i hibridni sistemi na bazi kalcijum fosfata i hidroksiapatita za preventivnu i regenerativnu medicinu

dc.creatorMilošević, Dragana
dc.creatorIgnjatović, Nenad
dc.creatorUskoković, Dragan
dc.date.accessioned2018-06-09T10:09:27Z
dc.date.available2018-06-09T10:09:27Z
dc.date.issued2017
dc.identifier.issn0040-2176
dc.identifier.urihttps://scindeks.ceon.rs/article.aspx?artid=0040-21761701011M
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/0040-21761701011M
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3358
dc.description.abstractThanks to its special caracteristics, such as relativly easy chemical modification of structure and surface, calciumphosphates (CaP) especially hydroxyapatite (HAp) is found widely used in various fields of biomedicine. Beside of the ease chemical modification, which includes metal doping, enhancement of properties of the HAp can be accomplished by combinations with various therapeutic and/or diagnostic agents. Materials base on CaP or HAp can be used in bone tissue engineering for reconstruction of bone damages as bone graft substitute as well as bone drug delivery systems. The improved properties of HAp were realized by doping with different elements (Co, Zn, Fe, Eu, Gd etc.). Synthesis, characterization and application of nanoparticulate multifunctional and hybrid materials based on CaP and HAp, is currently receiving tremendous attention. Multifunctional hybrid systems based on HAp could integrate medical preventive and regenerative potential in a single particle.
dc.description.abstractZahvaljujući svojim specifičnim svojstvima, kao što su modifikacija strukture i provšine, kalcijum-fosfati (CaP) posebno hidroksiapatit (HAp) se široko upotrebljavaju u mnogim oblastima biomedicine. Pored hemijske modifikacije, koja uključuje dopiranje metalima, unapređenje svojstava HAp-a se može postići kombinovanjem sa velikim brojem polimera kao i terapeutskih i/ili dijagnostičkih agenasa. Materijali na bazi CaP i HAp-a mogu se koristiti u inženjerstvu koštanog tkiva za rekonstrukciju kostiju kao graftovi ali i kao sistemi za dostavu lekova, gena, antikancer agenasa, itd. Unapređena svojstva HAp-a ostvarena su dopiranjem sa različitim elementima (Co, Zn, Fe, Eu, Gd itd.). Sinteza, karakterizacija i primena nanočestičnih multifunkcionalnih i hibridnih sistema na bazi CaP i HAp-a predstavlja istraživački izazov mnogim istraživačkim grupama. Multifunkcionalne i hibridne čestice na bazi HAp-a mogu da objedine medicinski preventivne/dijagnostičke i regenerativne potencijale u jednoj čestici.
dc.publisherBelgrade : Union of Engineers and Technicians of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsopenAccess
dc.sourceTehnika
dc.titleMultifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine
dc.titleMultifunkcionalni i hibridni sistemi na bazi kalcijum fosfata i hidroksiapatita za preventivnu i regenerativnu medicinu
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractУскоковић, Драган; Игњатовић, Ненад; Милошевић, Драгана; Мултифункционални и хибридни системи на бази калцијум фосфата и хидроксиапатита за превентивну и регенеративну медицину;
dc.citation.spage11
dc.citation.epage24
dc.citation.volume72
dc.citation.issue1
dc.identifier.doi10.5937/tehnika1701011M
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/10699/0040-21761701011M.pdf


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