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dc.creatorAjduković, Zorica
dc.creatorMihajilov Krstev, Tatjana
dc.creatorIgnjatović, Nenad
dc.creatorStojanović, Zoran S.
dc.creatorMladenović Antić, Snežana
dc.creatorKocić, Branislava
dc.creatorNajman, Stevo
dc.creatorPetrović, Nenad D.
dc.creatorUskoković, Dragan
dc.date.accessioned2018-04-11T10:12:16Z
dc.date.available2018-04-11T10:12:16Z
dc.date.issued2016
dc.identifier.issn1533-4880 (Print)
dc.identifier.issn1533-4899 (Online)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/2385
dc.description.abstractIn the field of oral implantology the loss of bone tissue prevents adequate patient care, and calls for the use of synthetic biomaterials with properties that resemble natural bone. Special attention is paid to the risk of infection after the implantation of these materials. Studies have suggested that some nanocontructs containing metal ions have antimicrobial properties. The aim of this study was to examine the antimicrobial and hemolytic activity of cobalt-substituted hydroxyapatite nanoparticles, compared to hydroxyapatite and hydroxyapatite/poly-lactide-co-glycolide. The antibacterial effects of these powders were tested against two pathogenic bacterial strains: Escherichia coi (ATCC 25922) and Staphylococcus aureus (ATCC 25923), using the disc diffusion method and the quantitative antimicrobial test in a liquid medium. The quantitative antimicrobial test showed that all of the tested biomaterials have some antibacterial properties. The effects of both tests were more prominent in case of S. aureus than in E coli. A higher percentage of cobalt in the crystal structure of cobalt-substituted hydroxyapatite nanoparticles led to an increased antimicrobial activity. All of the presented biomaterial samples were found to be non-hemolytic. Having in mind that the tested of cobalt-substituted hydroxyapatite (Ca/Co-HAp) material in given concentrations shows good hemocompatibility and antimicrobial effects, along with its previously studied biological properties, the conclusion can be reached that it is a potential candidate that could substitute calcium hydroxyapatite as the material of choice for use in bone tissue engineering and clinical practices in orthopedic, oral and maxillofacial surgery.en
dc.format16 2 (2016) 1420-1428
dc.languageen
dc.publisherAmerican Scientific Publishers
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41017/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Nanoscience and Nanotechnologyen
dc.subjectbone reconstruction
dc.subjectnanomaterials
dc.subjecthydroxyapatite
dc.subjectcobalt
dc.subjectantimicrobial effects
dc.titleIn Vitro Evaluation of Nanoscale Hydroxyapatite-Based Bone Reconstructive Materials with Antimicrobial Propertiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМихајилов Крстев, Татјана; Игњатовић, Ненад; Младеновић Aнтић, Снежана; Коцић, Бранислава; Петровић, Ненад Д.; Aјдуковић, Зорица; Стојановић, Зоран; Најман, Стево; Ускоковић, Драган;
dc.citation.spage1420
dc.citation.epage1428
dc.citation.volume16
dc.citation.issue2
dc.identifier.doi10.1166/jnn.2016.10699
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/2385/paper1306-2464.pdf


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