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dc.creatorJovanović, Ivana
dc.creatorJordović, Branka
dc.creatorPetković, Marijana
dc.creatorIgnjatović, Nenad
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2008
dc.identifier.issn1097-0029 (online)
dc.identifier.issn1059-910X (print)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/177
dc.description.abstractBiodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.en
dc.languageen
dc.publisherHoboken, NJ : John Wiley & Sons
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//
dc.rightsrestrictedAccess
dc.sourceMicroscopy Research and Techniqueen
dc.subjectmicrospheres
dc.subjectpoly(D,L-lactide)
dc.subjectmodified precipitation method
dc.subjectscanning electron microscopy
dc.subjectstereological analysis
dc.subjectPDLLA
dc.titlePreparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parametersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈордовић, Бранка; Петковић, Маријана; Јовановић, Ивана; Ускоковић, Драган; Игњатовић, Ненад;
dc.citation.spage86
dc.citation.epage92
dc.citation.volume72
dc.citation.issue2
dc.identifier.wos000253361200002
dc.identifier.doi10.1002/jemt.20529
dc.identifier.scopus2-s2.0-39449102972
dc.type.versionpublishedVersion


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