The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles
AuthorsStojanović, Zoran S.
Hwang, Mintai P.
Article (Accepted Version)
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We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.
Keywords:iron oxide / magnetic particles / nanocrystals / poly(l-lactide) / polyethyleneimine / solvothermal synthesis
Source:Colloids and Surfaces B: Biointerfaces, 2013, 109, 236-243
- Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
- National Research Foundation of Korea - R11-2008-0061852
- Korean Institute of Science and Technology - Institute of Technical Science of SASA joint research project Advanced Materials for Biomedical Applications
- This is the peer reviewed version of the following article: Stojanović, Zoran, Mojca Otoničar, Jongwook Lee, Magdalena M. Stevanović, Mintai P. Hwang, Kwan Hyi Lee, Jonghoon Choi, and Dragan Uskoković. 2013. “The Solvothermal Synthesis of Magnetic Iron Oxide Nanocrystals and the Preparation of Hybrid Poly(l-lactide)–polyethyleneimine Magnetic Particles.” Colloids and Surfaces B: Biointerfaces 109 (September 1): 236–243. http://dx.doi.org/ 10.1016/j.colsurfb.2013.03.053 .