Antioxidative Resveratrol Particles as a Bioactive Component for Material Design
Апстракт
There is a growing need for multifunctional components in material design, especially in tissue engineering. Among many natural compounds, polyphenols are gaining interest as biologically active additives of novel materials. Stilbenoid polyphenol resveratrol is one of the most known, mainly because of its antioxidative, antibacterial, anticancer, neuroprotective and other beneficial effects. To allow most efficient use of resveratrol, several nanoformulations have shown promise, but most of them also involve other, toxic or expensive compounds, beside resveratrol. During our research, we synthetized particles of pure resveratrol, in an elongated, nanobelt-like form. The shape of the particles, as well as absence of any polymer or other carriers makes these particles easy to handle for further implementation. For preliminary assessment of the functionality of these particles, several assays were employed. DPPH, TBA and FRAP assay proved antioxidative potential of obtained particles by s...everal mechanisms in the concentration range from 1 μg/mL to 10 μg/mL. Artemia salina in vivo bioassay was used to show high bioactivity and also biocompatibility of the particle suspension. All of the results indicated that there is a high potential for use of these resv
Кључне речи:
resveratrol / biomaterialsИзвор:
28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology, 2023, 87-87Издавач:
- Ljubljana : Inštitut za kovinske materiale in tehnologije
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200175 (Институт техничких наука САНУ, Београд) (RS-MESTD-inst-2020-200175)
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Tomić, Nina AU - Filipović, Nenad AU - Mitić Ćulafić, Dragana AU - Stevanović, Magdalena PY - 2023 UR - https://dais.sanu.ac.rs/123456789/15749 AB - There is a growing need for multifunctional components in material design, especially in tissue engineering. Among many natural compounds, polyphenols are gaining interest as biologically active additives of novel materials. Stilbenoid polyphenol resveratrol is one of the most known, mainly because of its antioxidative, antibacterial, anticancer, neuroprotective and other beneficial effects. To allow most efficient use of resveratrol, several nanoformulations have shown promise, but most of them also involve other, toxic or expensive compounds, beside resveratrol. During our research, we synthetized particles of pure resveratrol, in an elongated, nanobelt-like form. The shape of the particles, as well as absence of any polymer or other carriers makes these particles easy to handle for further implementation. For preliminary assessment of the functionality of these particles, several assays were employed. DPPH, TBA and FRAP assay proved antioxidative potential of obtained particles by several mechanisms in the concentration range from 1 μg/mL to 10 μg/mL. Artemia salina in vivo bioassay was used to show high bioactivity and also biocompatibility of the particle suspension. All of the results indicated that there is a high potential for use of these resv PB - Ljubljana : Inštitut za kovinske materiale in tehnologije C3 - 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology T1 - Antioxidative Resveratrol Particles as a Bioactive Component for Material Design SP - 87 EP - 87 UR - https://hdl.handle.net/21.15107/rcub_dais_15749 ER -
@conference{ author = "Tomić, Nina and Filipović, Nenad and Mitić Ćulafić, Dragana and Stevanović, Magdalena", year = "2023", abstract = "There is a growing need for multifunctional components in material design, especially in tissue engineering. Among many natural compounds, polyphenols are gaining interest as biologically active additives of novel materials. Stilbenoid polyphenol resveratrol is one of the most known, mainly because of its antioxidative, antibacterial, anticancer, neuroprotective and other beneficial effects. To allow most efficient use of resveratrol, several nanoformulations have shown promise, but most of them also involve other, toxic or expensive compounds, beside resveratrol. During our research, we synthetized particles of pure resveratrol, in an elongated, nanobelt-like form. The shape of the particles, as well as absence of any polymer or other carriers makes these particles easy to handle for further implementation. For preliminary assessment of the functionality of these particles, several assays were employed. DPPH, TBA and FRAP assay proved antioxidative potential of obtained particles by several mechanisms in the concentration range from 1 μg/mL to 10 μg/mL. Artemia salina in vivo bioassay was used to show high bioactivity and also biocompatibility of the particle suspension. All of the results indicated that there is a high potential for use of these resv", publisher = "Ljubljana : Inštitut za kovinske materiale in tehnologije", journal = "28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology", title = "Antioxidative Resveratrol Particles as a Bioactive Component for Material Design", pages = "87-87", url = "https://hdl.handle.net/21.15107/rcub_dais_15749" }
Tomić, N., Filipović, N., Mitić Ćulafić, D.,& Stevanović, M.. (2023). Antioxidative Resveratrol Particles as a Bioactive Component for Material Design. in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology Ljubljana : Inštitut za kovinske materiale in tehnologije., 87-87. https://hdl.handle.net/21.15107/rcub_dais_15749
Tomić N, Filipović N, Mitić Ćulafić D, Stevanović M. Antioxidative Resveratrol Particles as a Bioactive Component for Material Design. in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology. 2023;:87-87. https://hdl.handle.net/21.15107/rcub_dais_15749 .
Tomić, Nina, Filipović, Nenad, Mitić Ćulafić, Dragana, Stevanović, Magdalena, "Antioxidative Resveratrol Particles as a Bioactive Component for Material Design" in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology (2023):87-87, https://hdl.handle.net/21.15107/rcub_dais_15749 .