Show simple item record

dc.creatorĐorđević, Ljubiša
dc.creatorNajman, Stevo
dc.creatorVasiljević, Perica
dc.creatorMiljković, Miroslav
dc.creatorIgnjatović, Nenad
dc.creatorUskoković, Dragan
dc.creatorPlavšić, Milenko
dc.date.accessioned2017-12-11T15:39:38Z
dc.date.available2017-12-11T15:39:38Z
dc.date.issued2016
dc.identifier.issn1820-7448 (Online)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/15457
dc.description.abstractImplantation of a biomaterial is one of the important trends in solving the problem of bone tissue loss. Calcium hydroxiapatite (HAp), as the most representative bone component is a serious candidate for such implantations. The synthetic polymer poly-L-lactide (PLLA) in HAp/PLLA is often used as a polymeric material, with a role in the substitution of bone tissue collagen fibers. Fibers of PLLA may strengthen HAp and its good bioresorption provides space for tissue remodeling. Differences in porosity, microstructure, compressive consistency as well as bioresorbility of HAp/PLLA may be achieved by using PLLA with different molecular weights. In this study HAp/PLLA composites with PLLA of different molecular weights (50,000; 160,000 and 430,000) were implanted in mouse peritoneum in order to examine the influence of the molecular weight of PLLA on morphology changes. Microstructural changes of biomaterial (HAp/PLLA) surface were analyzed one week, three weeks and four months after their implantation using Scanning Electron Microscopy. The results showed a significant difference in tissue reactions on the applied biocomposites, depending on their molecular weight. The most intense proliferation of cells was induced by HAp/PLLA 50,000 compared to HAp/PLLA 430,000 and HAp/PLLA 160,000. In the vicinity of HAp/PLLA 430,000 abundant erythrocytes were observed. The differences in biological reactions on the examined biocomposites are significant for their practical applications. HAp/PLLA composite biomaterials of different types and resorption rates require specific designing and programming to become suitable for particular purposes in an organism.eng
dc.format66 2 (2016) 234-244
dc.formatapplication/pdf
dc.languageen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsopenAccess
dc.sourceActa Veterinariaeng
dc.subjectcalcium hydroxiapatite
dc.subjectpoly-L-lactide
dc.subjectimplant
dc.subjectmouse
dc.subjectperitoneum
dc.titleScanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantationeng
dc.typearticle
dc.rights.licenseBY
dcterms.abstractНајман, Стево; Васиљевић, Перица; Миљковић, Мирослав; Игњатовић, Ненад; Ускоковић, Драган; Плавшић, Миленко; Ђорђевић, Љубиша;
dc.citation.spage234
dc.citation.epage244
dc.citation.volume66
dc.citation.issue2
dc.identifier.wos000384770600008
dc.identifier.doi10.1515/acve-2016-0020
dc.identifier.scopus2-s2.0-84978869410
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/20028/1797.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record