Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid
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This paper is covering new, simplistic method of obtaining the system for controlled delivery of the ascorbic acid. Copolymer poly (D,L-lactide-co-glycolide) (DLPLG) nanoparticles are produced using physical method with solvent/nonsolvent systems where obtained solutions were centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenization of water and organic phases. Particles of the DLPLG with the different content of ascorbic acid have different morphological characteristics, that is, variable degree of uniformity, agglomeration, sizes, and spherical shaping. Mean sizes of nanoparticles, which contain DLPLG/ascorbic acid in the ratio 85/150%, were between 130 to 200 nm depending on which stereological parameters are considered (maximal diameters Dmax, feret X, or feret Y). By introducing up to 15% of ascorbic acid, the spherical shape, size, and uniformity of DLPLG particles are preserved. The samples were characterized by infrared spectroscop...y, scanning electron microscopy, stereological analysis, and ultraviolet spectroscopy.
Кључне речи:
ascorbic acid / Poly(D,L-Lactide-co-Glycolide) / nanomaterials / biomaterialsИзвор:
Journal of Biomedicine and Biotechnology, 2007, 2007, 1-8Издавач:
- Hindawi
Финансирање / пројекти:
- Синтеза функционалних материјала са контролисаном структуром на молекуларном и нано нивоу (RS-MESTD-MPN2006-2010-142006)
DOI: 10.1155/2007/84965
ISSN: 1110-7243; 1110-7251
WoS: 000252054300001
Scopus: 2-s2.0-36949000062
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Stevanović, Magdalena AU - Jordović, Branka AU - Uskoković, Dragan PY - 2007 UR - https://dais.sanu.ac.rs/123456789/15267 AB - This paper is covering new, simplistic method of obtaining the system for controlled delivery of the ascorbic acid. Copolymer poly (D,L-lactide-co-glycolide) (DLPLG) nanoparticles are produced using physical method with solvent/nonsolvent systems where obtained solutions were centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenization of water and organic phases. Particles of the DLPLG with the different content of ascorbic acid have different morphological characteristics, that is, variable degree of uniformity, agglomeration, sizes, and spherical shaping. Mean sizes of nanoparticles, which contain DLPLG/ascorbic acid in the ratio 85/150%, were between 130 to 200 nm depending on which stereological parameters are considered (maximal diameters Dmax, feret X, or feret Y). By introducing up to 15% of ascorbic acid, the spherical shape, size, and uniformity of DLPLG particles are preserved. The samples were characterized by infrared spectroscopy, scanning electron microscopy, stereological analysis, and ultraviolet spectroscopy. PB - Hindawi T2 - Journal of Biomedicine and Biotechnology T1 - Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid SP - 1 EP - 8 VL - 2007 DO - 10.1155/2007/84965 UR - https://hdl.handle.net/21.15107/rcub_dais_15267 ER -
@article{ author = "Stevanović, Magdalena and Jordović, Branka and Uskoković, Dragan", year = "2007", abstract = "This paper is covering new, simplistic method of obtaining the system for controlled delivery of the ascorbic acid. Copolymer poly (D,L-lactide-co-glycolide) (DLPLG) nanoparticles are produced using physical method with solvent/nonsolvent systems where obtained solutions were centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenization of water and organic phases. Particles of the DLPLG with the different content of ascorbic acid have different morphological characteristics, that is, variable degree of uniformity, agglomeration, sizes, and spherical shaping. Mean sizes of nanoparticles, which contain DLPLG/ascorbic acid in the ratio 85/150%, were between 130 to 200 nm depending on which stereological parameters are considered (maximal diameters Dmax, feret X, or feret Y). By introducing up to 15% of ascorbic acid, the spherical shape, size, and uniformity of DLPLG particles are preserved. The samples were characterized by infrared spectroscopy, scanning electron microscopy, stereological analysis, and ultraviolet spectroscopy.", publisher = "Hindawi", journal = "Journal of Biomedicine and Biotechnology", title = "Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid", pages = "1-8", volume = "2007", doi = "10.1155/2007/84965", url = "https://hdl.handle.net/21.15107/rcub_dais_15267" }
Stevanović, M., Jordović, B.,& Uskoković, D.. (2007). Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid. in Journal of Biomedicine and Biotechnology Hindawi., 2007, 1-8. https://doi.org/10.1155/2007/84965 https://hdl.handle.net/21.15107/rcub_dais_15267
Stevanović M, Jordović B, Uskoković D. Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid. in Journal of Biomedicine and Biotechnology. 2007;2007:1-8. doi:10.1155/2007/84965 https://hdl.handle.net/21.15107/rcub_dais_15267 .
Stevanović, Magdalena, Jordović, Branka, Uskoković, Dragan, "Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid" in Journal of Biomedicine and Biotechnology, 2007 (2007):1-8, https://doi.org/10.1155/2007/84965 ., https://hdl.handle.net/21.15107/rcub_dais_15267 .