Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium Phosphate/Poly-DL-lactide-co-glycolide Biomaterials
Само за регистроване кориснике
2007
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Lost bone tissue due to osteoporosis makes dentistry very difficult. The aim of thisstudy is to reconstruct the bone tissue with composite biomaterials and to estimate the optical density and alveolar ridge height of the mandible. Research is conducted on 30 postmenopausal women aged from 46 to 62 years, with diagnosed osteoporosis and defects in alveolar bones caused by extraction of paradontopathic teeth, enucleation of cysts and periapical changes, extraction of impacted teeth,or by trauma.Biphasic calcium phosphate/poly-DL-lactide-co-glycolide (BCP/PLGA) composite is implanted into the defects of alveolar bones. Six weeks after implantation of BCP/PLGA, the alveolar bone density in the region of premolars on the experimental side of the jaw is found to be lower than that on the untreated, control, side of the jaw. On thecontrary, 24 weeks after implantation, it is significantly higher compared with the density of the control side. A significant increase in optical density of alveol...ar bones in the region of premolars on the experimental side compared with the control one is noticed. These results indicate a high level of osteoregeneration and osteoblast activity. Synthetic BCP/PLGA composite belongs to the group of biomaterials, which facilitate formation of new bones and rehabilitation of alveolar bones weakened by osteoporosis. Because of its osteoconductive characteristics, BCP/PLGA composite is supposed to be the material of choice for replacement of bone tissue in the future.
Кључне речи:
calcium phosphate / bone tissue / osteoporosis / poly- DL -lactide-co-glycolideИзвор:
Journal of Biomaterials Applications, 2007, 21, 3, 317-328Издавач:
- SAGE Publications
DOI: 10.1177/0885328207073760
ISSN: 0885-3282; 1530-8022
WoS: 000243528400007
Scopus: 2-s2.0-33846222895
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Ajduković, Zorica AU - Ignjatović, Nenad AU - Petrović, Dragan AU - Uskoković, Dragan PY - 2007 UR - https://dais.sanu.ac.rs/123456789/14366 AB - Lost bone tissue due to osteoporosis makes dentistry very difficult. The aim of thisstudy is to reconstruct the bone tissue with composite biomaterials and to estimate the optical density and alveolar ridge height of the mandible. Research is conducted on 30 postmenopausal women aged from 46 to 62 years, with diagnosed osteoporosis and defects in alveolar bones caused by extraction of paradontopathic teeth, enucleation of cysts and periapical changes, extraction of impacted teeth,or by trauma.Biphasic calcium phosphate/poly-DL-lactide-co-glycolide (BCP/PLGA) composite is implanted into the defects of alveolar bones. Six weeks after implantation of BCP/PLGA, the alveolar bone density in the region of premolars on the experimental side of the jaw is found to be lower than that on the untreated, control, side of the jaw. On thecontrary, 24 weeks after implantation, it is significantly higher compared with the density of the control side. A significant increase in optical density of alveolar bones in the region of premolars on the experimental side compared with the control one is noticed. These results indicate a high level of osteoregeneration and osteoblast activity. Synthetic BCP/PLGA composite belongs to the group of biomaterials, which facilitate formation of new bones and rehabilitation of alveolar bones weakened by osteoporosis. Because of its osteoconductive characteristics, BCP/PLGA composite is supposed to be the material of choice for replacement of bone tissue in the future. PB - SAGE Publications T2 - Journal of Biomaterials Applications T1 - Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium Phosphate/Poly-DL-lactide-co-glycolide Biomaterials SP - 317 EP - 328 VL - 21 IS - 3 DO - 10.1177/0885328207073760 UR - https://hdl.handle.net/21.15107/rcub_dais_14366 ER -
@article{ author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Dragan and Uskoković, Dragan", year = "2007", abstract = "Lost bone tissue due to osteoporosis makes dentistry very difficult. The aim of thisstudy is to reconstruct the bone tissue with composite biomaterials and to estimate the optical density and alveolar ridge height of the mandible. Research is conducted on 30 postmenopausal women aged from 46 to 62 years, with diagnosed osteoporosis and defects in alveolar bones caused by extraction of paradontopathic teeth, enucleation of cysts and periapical changes, extraction of impacted teeth,or by trauma.Biphasic calcium phosphate/poly-DL-lactide-co-glycolide (BCP/PLGA) composite is implanted into the defects of alveolar bones. Six weeks after implantation of BCP/PLGA, the alveolar bone density in the region of premolars on the experimental side of the jaw is found to be lower than that on the untreated, control, side of the jaw. On thecontrary, 24 weeks after implantation, it is significantly higher compared with the density of the control side. A significant increase in optical density of alveolar bones in the region of premolars on the experimental side compared with the control one is noticed. These results indicate a high level of osteoregeneration and osteoblast activity. Synthetic BCP/PLGA composite belongs to the group of biomaterials, which facilitate formation of new bones and rehabilitation of alveolar bones weakened by osteoporosis. Because of its osteoconductive characteristics, BCP/PLGA composite is supposed to be the material of choice for replacement of bone tissue in the future.", publisher = "SAGE Publications", journal = "Journal of Biomaterials Applications", title = "Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium Phosphate/Poly-DL-lactide-co-glycolide Biomaterials", pages = "317-328", volume = "21", number = "3", doi = "10.1177/0885328207073760", url = "https://hdl.handle.net/21.15107/rcub_dais_14366" }
Ajduković, Z., Ignjatović, N., Petrović, D.,& Uskoković, D.. (2007). Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium Phosphate/Poly-DL-lactide-co-glycolide Biomaterials. in Journal of Biomaterials Applications SAGE Publications., 21(3), 317-328. https://doi.org/10.1177/0885328207073760 https://hdl.handle.net/21.15107/rcub_dais_14366
Ajduković Z, Ignjatović N, Petrović D, Uskoković D. Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium Phosphate/Poly-DL-lactide-co-glycolide Biomaterials. in Journal of Biomaterials Applications. 2007;21(3):317-328. doi:10.1177/0885328207073760 https://hdl.handle.net/21.15107/rcub_dais_14366 .
Ajduković, Zorica, Ignjatović, Nenad, Petrović, Dragan, Uskoković, Dragan, "Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium Phosphate/Poly-DL-lactide-co-glycolide Biomaterials" in Journal of Biomaterials Applications, 21, no. 3 (2007):317-328, https://doi.org/10.1177/0885328207073760 ., https://hdl.handle.net/21.15107/rcub_dais_14366 .