Stereological analysis of the poly-(dl-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing
Само за регистроване кориснике
2007
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Fine particles made of poly(lactide-co-glycolide) (DLPLG) are excellent candidates for controlled release of delivering drugs and genes, because of their degradable nature. The preparation of DLPLG submicron spheres poses serious challenges that are not necessarily present when preparing macroparticles. In the present paper, DLPLG powder is produced with chemical method using solvent/non-solvent systems with subsequent centrifugation of the solution. The samples were characterized by infrared spectroscopy (IR), scanning electron microscopy (SEM) and stereological analysis. By changing the aging time with non-solvent and time and velocity of the centrifugal processing, it is possible to influence on the morphology and uniformity of the copolymer particles. Powder of the series with short aging time with non-solvent and longest time and velocity of the centrifugal processing has smallest particles and highest uniformity, where mean particles sizes were between 150 nm and 230 nm depending... on which stereological parameters are considered (D(max), maximal diameters, feret X or feret Y).
Кључне речи:
supercritical fluid extraction / stereological analysis / emulsion process / centrifugal processingИзвор:
Journal of Materials Science: Materials in Medicine, 2007, 18, 7, 1339-1344Издавач:
- Springer Science and Business Media LLC
DOI: 10.1007/s10856-007-0156-8
ISSN: 0957-4530; 1573-4838
WoS: 000247653900009
Scopus: 2-s2.0-34347223993
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Stevanović, Magdalena AU - Ignjatović, Nenad AU - Jordović, Branka AU - Uskoković, Dragan PY - 2007 UR - https://dais.sanu.ac.rs/123456789/14365 AB - Fine particles made of poly(lactide-co-glycolide) (DLPLG) are excellent candidates for controlled release of delivering drugs and genes, because of their degradable nature. The preparation of DLPLG submicron spheres poses serious challenges that are not necessarily present when preparing macroparticles. In the present paper, DLPLG powder is produced with chemical method using solvent/non-solvent systems with subsequent centrifugation of the solution. The samples were characterized by infrared spectroscopy (IR), scanning electron microscopy (SEM) and stereological analysis. By changing the aging time with non-solvent and time and velocity of the centrifugal processing, it is possible to influence on the morphology and uniformity of the copolymer particles. Powder of the series with short aging time with non-solvent and longest time and velocity of the centrifugal processing has smallest particles and highest uniformity, where mean particles sizes were between 150 nm and 230 nm depending on which stereological parameters are considered (D(max), maximal diameters, feret X or feret Y). PB - Springer Science and Business Media LLC T2 - Journal of Materials Science: Materials in Medicine T1 - Stereological analysis of the poly-(dl-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing SP - 1339 EP - 1344 VL - 18 IS - 7 DO - 10.1007/s10856-007-0156-8 UR - https://hdl.handle.net/21.15107/rcub_dais_14365 ER -
@article{ author = "Stevanović, Magdalena and Ignjatović, Nenad and Jordović, Branka and Uskoković, Dragan", year = "2007", abstract = "Fine particles made of poly(lactide-co-glycolide) (DLPLG) are excellent candidates for controlled release of delivering drugs and genes, because of their degradable nature. The preparation of DLPLG submicron spheres poses serious challenges that are not necessarily present when preparing macroparticles. In the present paper, DLPLG powder is produced with chemical method using solvent/non-solvent systems with subsequent centrifugation of the solution. The samples were characterized by infrared spectroscopy (IR), scanning electron microscopy (SEM) and stereological analysis. By changing the aging time with non-solvent and time and velocity of the centrifugal processing, it is possible to influence on the morphology and uniformity of the copolymer particles. Powder of the series with short aging time with non-solvent and longest time and velocity of the centrifugal processing has smallest particles and highest uniformity, where mean particles sizes were between 150 nm and 230 nm depending on which stereological parameters are considered (D(max), maximal diameters, feret X or feret Y).", publisher = "Springer Science and Business Media LLC", journal = "Journal of Materials Science: Materials in Medicine", title = "Stereological analysis of the poly-(dl-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing", pages = "1339-1344", volume = "18", number = "7", doi = "10.1007/s10856-007-0156-8", url = "https://hdl.handle.net/21.15107/rcub_dais_14365" }
Stevanović, M., Ignjatović, N., Jordović, B.,& Uskoković, D.. (2007). Stereological analysis of the poly-(dl-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing. in Journal of Materials Science: Materials in Medicine Springer Science and Business Media LLC., 18(7), 1339-1344. https://doi.org/10.1007/s10856-007-0156-8 https://hdl.handle.net/21.15107/rcub_dais_14365
Stevanović M, Ignjatović N, Jordović B, Uskoković D. Stereological analysis of the poly-(dl-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing. in Journal of Materials Science: Materials in Medicine. 2007;18(7):1339-1344. doi:10.1007/s10856-007-0156-8 https://hdl.handle.net/21.15107/rcub_dais_14365 .
Stevanović, Magdalena, Ignjatović, Nenad, Jordović, Branka, Uskoković, Dragan, "Stereological analysis of the poly-(dl-lactide-co-glycolide) submicron sphere prepared by solvent/non-solvent chemical methods and centrifugal processing" in Journal of Materials Science: Materials in Medicine, 18, no. 7 (2007):1339-1344, https://doi.org/10.1007/s10856-007-0156-8 ., https://hdl.handle.net/21.15107/rcub_dais_14365 .