Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid
2023
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Аутори
Batinić, Petar M.Đorđević, Verica
Obradović, Nataša S.
Krstić, Aleksandar D.
Stevanović, Sanja
Balanč, Bojana
Marković, Smilja
Pjanović, Rada
Mijin, Dušan
Bugarski, Branko
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
Liposome-encapsulated folic acid was incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of carboxymethyl cellulose and solagum (9:1 w/w) using the film-forming cast solution method. Histidine was used to increase solubility for folic acid in liposomes (1-5 mg/ml), and propylene glycol was used as a film plasticizer (2.6 mas%). The obtained films (50-60 µm tick) containing 3.12-20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films were scrutinized. Folic acid gave yellow color to the films and contributed to stronger chemical bonds which resulted in improved strength of the film. Liposomes prolonged the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degraded homogeneity of the films, which could be ascribed to its agglomeration within t...he film matrix as revealed by AFM. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg/ml liposome-encapsulated folic acid is recommended from the point of view of release kinetics determined by its solubility. Practical application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.
Кључне речи:
liposomes / folic acid / sodium carboxymethyl cellulose / transdermal delivery / controlled releaseИзвор:
European Journal of Lipid Science and Technology, 2023, 125, 7, 2200169-Издавач:
- Wiley
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200175 (Институт техничких наука САНУ, Београд) (RS-MESTD-inst-2020-200175)
Напомена:
- This is the peer-reviewed version of the article: Batinić, P. M.; Đorđević, V. B.; Obradović, N. S.; Krstić, A. D.; Stevanović, S. I.; Balanč, B. D.; Marković, S. B.; Pjanović, R. V.; Mijin, D. Ž.; Bugarski, B. M. Polymer-Lipid Matrice Based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid. European Journal of Lipid Science and Technology n/a (n/a), 2200169. https://doi.org/10.1002/ejlt.202200169.
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Batinić, Petar M. AU - Đorđević, Verica AU - Obradović, Nataša S. AU - Krstić, Aleksandar D. AU - Stevanović, Sanja AU - Balanč, Bojana AU - Marković, Smilja AU - Pjanović, Rada AU - Mijin, Dušan AU - Bugarski, Branko PY - 2023 UR - https://dais.sanu.ac.rs/123456789/14283 AB - Liposome-encapsulated folic acid was incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of carboxymethyl cellulose and solagum (9:1 w/w) using the film-forming cast solution method. Histidine was used to increase solubility for folic acid in liposomes (1-5 mg/ml), and propylene glycol was used as a film plasticizer (2.6 mas%). The obtained films (50-60 µm tick) containing 3.12-20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films were scrutinized. Folic acid gave yellow color to the films and contributed to stronger chemical bonds which resulted in improved strength of the film. Liposomes prolonged the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degraded homogeneity of the films, which could be ascribed to its agglomeration within the film matrix as revealed by AFM. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg/ml liposome-encapsulated folic acid is recommended from the point of view of release kinetics determined by its solubility. Practical application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide. PB - Wiley T2 - European Journal of Lipid Science and Technology T1 - Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid SP - 2200169 VL - 125 IS - 7 DO - 10.1002/ejlt.202200169 UR - https://hdl.handle.net/21.15107/rcub_dais_14283 ER -
@article{ author = "Batinić, Petar M. and Đorđević, Verica and Obradović, Nataša S. and Krstić, Aleksandar D. and Stevanović, Sanja and Balanč, Bojana and Marković, Smilja and Pjanović, Rada and Mijin, Dušan and Bugarski, Branko", year = "2023", abstract = "Liposome-encapsulated folic acid was incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of carboxymethyl cellulose and solagum (9:1 w/w) using the film-forming cast solution method. Histidine was used to increase solubility for folic acid in liposomes (1-5 mg/ml), and propylene glycol was used as a film plasticizer (2.6 mas%). The obtained films (50-60 µm tick) containing 3.12-20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films were scrutinized. Folic acid gave yellow color to the films and contributed to stronger chemical bonds which resulted in improved strength of the film. Liposomes prolonged the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degraded homogeneity of the films, which could be ascribed to its agglomeration within the film matrix as revealed by AFM. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg/ml liposome-encapsulated folic acid is recommended from the point of view of release kinetics determined by its solubility. Practical application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.", publisher = "Wiley", journal = "European Journal of Lipid Science and Technology", title = "Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid", pages = "2200169", volume = "125", number = "7", doi = "10.1002/ejlt.202200169", url = "https://hdl.handle.net/21.15107/rcub_dais_14283" }
Batinić, P. M., Đorđević, V., Obradović, N. S., Krstić, A. D., Stevanović, S., Balanč, B., Marković, S., Pjanović, R., Mijin, D.,& Bugarski, B.. (2023). Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid. in European Journal of Lipid Science and Technology Wiley., 125(7), 2200169. https://doi.org/10.1002/ejlt.202200169 https://hdl.handle.net/21.15107/rcub_dais_14283
Batinić PM, Đorđević V, Obradović NS, Krstić AD, Stevanović S, Balanč B, Marković S, Pjanović R, Mijin D, Bugarski B. Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid. in European Journal of Lipid Science and Technology. 2023;125(7):2200169. doi:10.1002/ejlt.202200169 https://hdl.handle.net/21.15107/rcub_dais_14283 .
Batinić, Petar M., Đorđević, Verica, Obradović, Nataša S., Krstić, Aleksandar D., Stevanović, Sanja, Balanč, Bojana, Marković, Smilja, Pjanović, Rada, Mijin, Dušan, Bugarski, Branko, "Polymer‐lipid matrice based on carboxymethyl cellulose/solagum and liposomes for controlled release of folic acid" in European Journal of Lipid Science and Technology, 125, no. 7 (2023):2200169, https://doi.org/10.1002/ejlt.202200169 ., https://hdl.handle.net/21.15107/rcub_dais_14283 .