A single dose of microplastic particles induces changed in organ weight of male Wistar rats
2021
Преузимање 🢃
Аутори
Stojanović, ZoranTodorović, Ana
Martinović, Jelena
Filipović, Nenad
Veljković, Filip
Guševac Stojanović, Ivana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Increased plastic usage creates environmental problems due to its accumulation and degradation into microplastic particles (MP), less than 5 mm in diameter. Particles from various sources like food and beverages contaminated with polyethylene terephthalate (PET) could accumulate in different tissues exerting adverse effects. Since data regarding potential acute toxicity in doses that represent realistic/daily ingested MP doses are entirely lacking, male Wistar rats were exposed to a single dose (1.4, 35 or 125 mg/kg) of PET-generated MP by oral gavage. Changes in wet organ weight to body weight ratio of testicles, adrenal glands and kidneys were examined 24 h following the treatment. Results point to increased organ/body weight ratio of testicles in rats exposed to two higher MP doses, while adrenal glands were augmented only after treatment with 125 mg/kg. Further research is needed to gain insight into the underlying mechanisms of the observed phenomenon.
Кључне речи:
microplastic particles / polyethylene terephthalate / toxicity / health statusИзвор:
Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021, 2021, 119-122Издавач:
- Belgrade : Vinča Institute of Nuclear Sciences
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200175 (Институт техничких наука САНУ, Београд) (RS-MESTD-inst-2020-200175)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Stojanović, Zoran AU - Todorović, Ana AU - Martinović, Jelena AU - Filipović, Nenad AU - Veljković, Filip AU - Guševac Stojanović, Ivana PY - 2021 UR - https://dais.sanu.ac.rs/123456789/12381 AB - Increased plastic usage creates environmental problems due to its accumulation and degradation into microplastic particles (MP), less than 5 mm in diameter. Particles from various sources like food and beverages contaminated with polyethylene terephthalate (PET) could accumulate in different tissues exerting adverse effects. Since data regarding potential acute toxicity in doses that represent realistic/daily ingested MP doses are entirely lacking, male Wistar rats were exposed to a single dose (1.4, 35 or 125 mg/kg) of PET-generated MP by oral gavage. Changes in wet organ weight to body weight ratio of testicles, adrenal glands and kidneys were examined 24 h following the treatment. Results point to increased organ/body weight ratio of testicles in rats exposed to two higher MP doses, while adrenal glands were augmented only after treatment with 125 mg/kg. Further research is needed to gain insight into the underlying mechanisms of the observed phenomenon. PB - Belgrade : Vinča Institute of Nuclear Sciences C3 - Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 T1 - A single dose of microplastic particles induces changed in organ weight of male Wistar rats SP - 119 EP - 122 UR - https://hdl.handle.net/21.15107/rcub_dais_12381 ER -
@conference{ author = "Stojanović, Zoran and Todorović, Ana and Martinović, Jelena and Filipović, Nenad and Veljković, Filip and Guševac Stojanović, Ivana", year = "2021", abstract = "Increased plastic usage creates environmental problems due to its accumulation and degradation into microplastic particles (MP), less than 5 mm in diameter. Particles from various sources like food and beverages contaminated with polyethylene terephthalate (PET) could accumulate in different tissues exerting adverse effects. Since data regarding potential acute toxicity in doses that represent realistic/daily ingested MP doses are entirely lacking, male Wistar rats were exposed to a single dose (1.4, 35 or 125 mg/kg) of PET-generated MP by oral gavage. Changes in wet organ weight to body weight ratio of testicles, adrenal glands and kidneys were examined 24 h following the treatment. Results point to increased organ/body weight ratio of testicles in rats exposed to two higher MP doses, while adrenal glands were augmented only after treatment with 125 mg/kg. Further research is needed to gain insight into the underlying mechanisms of the observed phenomenon.", publisher = "Belgrade : Vinča Institute of Nuclear Sciences", journal = "Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021", title = "A single dose of microplastic particles induces changed in organ weight of male Wistar rats", pages = "119-122", url = "https://hdl.handle.net/21.15107/rcub_dais_12381" }
Stojanović, Z., Todorović, A., Martinović, J., Filipović, N., Veljković, F.,& Guševac Stojanović, I.. (2021). A single dose of microplastic particles induces changed in organ weight of male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 Belgrade : Vinča Institute of Nuclear Sciences., 119-122. https://hdl.handle.net/21.15107/rcub_dais_12381
Stojanović Z, Todorović A, Martinović J, Filipović N, Veljković F, Guševac Stojanović I. A single dose of microplastic particles induces changed in organ weight of male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021. 2021;:119-122. https://hdl.handle.net/21.15107/rcub_dais_12381 .
Stojanović, Zoran, Todorović, Ana, Martinović, Jelena, Filipović, Nenad, Veljković, Filip, Guševac Stojanović, Ivana, "A single dose of microplastic particles induces changed in organ weight of male Wistar rats" in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 (2021):119-122, https://hdl.handle.net/21.15107/rcub_dais_12381 .