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Plavšić, Milenko

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  • Plavšić, Milenko (5)
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Author's Bibliography

Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation

Đorđević, Ljubiša; Najman, Stevo; Vasiljević, Perica; Miljković, Miroslav; Ignjatović, Nenad; Uskoković, Dragan; Plavšić, Milenko

(2016)

TY  - JOUR
AU  - Đorđević, Ljubiša
AU  - Najman, Stevo
AU  - Vasiljević, Perica
AU  - Miljković, Miroslav
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
AU  - Plavšić, Milenko
PY  - 2016
UR  - http://dais.sanu.ac.rs/123456789/15457
AB  - Implantation of a biomaterial is one of the important trends in solving the problem of bone tissue loss. Calcium hydroxiapatite (HAp), as the most representative bone component is a serious candidate for such implantations. The synthetic polymer poly-L-lactide (PLLA) in HAp/PLLA is often used as a polymeric material, with a role in the substitution of bone tissue collagen fibers. Fibers of PLLA may strengthen HAp and its good bioresorption provides space for tissue remodeling. Differences in porosity, microstructure, compressive consistency as well as bioresorbility of HAp/PLLA may be achieved by using PLLA with different molecular weights. In this study HAp/PLLA composites with PLLA of different molecular weights (50,000; 160,000 and 430,000) were implanted in mouse peritoneum in order to examine the influence of the molecular weight of PLLA on morphology changes. Microstructural changes of biomaterial (HAp/PLLA) surface were analyzed one week, three weeks and four months after their implantation using Scanning Electron Microscopy. The results showed a significant difference in tissue reactions on the applied biocomposites, depending on their molecular weight. The most intense proliferation of cells was induced by HAp/PLLA 50,000 compared to HAp/PLLA 430,000 and HAp/PLLA 160,000. In the vicinity of HAp/PLLA 430,000 abundant erythrocytes were observed. The differences in biological reactions on the examined biocomposites are significant for their practical applications. HAp/PLLA composite biomaterials of different types and resorption rates require specific designing and programming to become suitable for particular purposes in an organism.
T2  - Acta Veterinaria
T1  - Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation
SP  - 234
EP  - 244
VL  - 66
IS  - 2
DO  - 10.1515/acve-2016-0020
ER  - 
@article{
author = "Đorđević, Ljubiša and Najman, Stevo and Vasiljević, Perica and Miljković, Miroslav and Ignjatović, Nenad and Uskoković, Dragan and Plavšić, Milenko",
year = "2016",
url = "http://dais.sanu.ac.rs/123456789/15457",
abstract = "Implantation of a biomaterial is one of the important trends in solving the problem of bone tissue loss. Calcium hydroxiapatite (HAp), as the most representative bone component is a serious candidate for such implantations. The synthetic polymer poly-L-lactide (PLLA) in HAp/PLLA is often used as a polymeric material, with a role in the substitution of bone tissue collagen fibers. Fibers of PLLA may strengthen HAp and its good bioresorption provides space for tissue remodeling. Differences in porosity, microstructure, compressive consistency as well as bioresorbility of HAp/PLLA may be achieved by using PLLA with different molecular weights. In this study HAp/PLLA composites with PLLA of different molecular weights (50,000; 160,000 and 430,000) were implanted in mouse peritoneum in order to examine the influence of the molecular weight of PLLA on morphology changes. Microstructural changes of biomaterial (HAp/PLLA) surface were analyzed one week, three weeks and four months after their implantation using Scanning Electron Microscopy. The results showed a significant difference in tissue reactions on the applied biocomposites, depending on their molecular weight. The most intense proliferation of cells was induced by HAp/PLLA 50,000 compared to HAp/PLLA 430,000 and HAp/PLLA 160,000. In the vicinity of HAp/PLLA 430,000 abundant erythrocytes were observed. The differences in biological reactions on the examined biocomposites are significant for their practical applications. HAp/PLLA composite biomaterials of different types and resorption rates require specific designing and programming to become suitable for particular purposes in an organism.",
journal = "Acta Veterinaria",
title = "Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation",
pages = "234-244",
volume = "66",
number = "2",
doi = "10.1515/acve-2016-0020"
}
Đorđević, L., Najman, S., Vasiljević, P., Miljković, M., Ignjatović, N., Uskoković, D.,& Plavšić, M. (2016). Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation.
Acta Veterinaria, 66(2), 234-244. 
https://doi.org/10.1515/acve-2016-0020
Đorđević L, Najman S, Vasiljević P, Miljković M, Ignjatović N, Uskoković D, Plavšić M. Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation. Acta Veterinaria. 2016;66(2):234-244

Biomaterijali

Balać, Igor; Bugarski, Branko; Ćosić, Irena; Dramićanin, Miroslav; Đorđević, Drago; Filipović, Nenad D.; Ignjatović, Nenad; Janaćković, Đorđe; Kojić, Miloš; Manojlović, Verica; Marković, Zoran; Obradović, Bojana; Pajić Lijaković, Ivana; Pavlović, Miodrag; Plavšić, Milenko; Raković, Dejan; Ranković, Vladimir; Stojanović, Boban; Trajković, Vladimir; Uskoković, Dragan; Uskoković, Petar S.; Veljković, Dejan; Vlastelica, Ivo; Vunjak Novaković, Gordana

(Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala, 2010)

TY  - BOOK
AU  - Balać, Igor
AU  - Bugarski, Branko
AU  - Ćosić, Irena
AU  - Dramićanin, Miroslav
AU  - Đorđević, Drago
AU  - Filipović, Nenad D.
AU  - Ignjatović, Nenad
AU  - Janaćković, Đorđe
AU  - Kojić, Miloš
AU  - Manojlović, Verica
AU  - Marković, Zoran
AU  - Obradović, Bojana
AU  - Pajić Lijaković, Ivana
AU  - Pavlović, Miodrag
AU  - Plavšić, Milenko
AU  - Raković, Dejan
AU  - Ranković, Vladimir
AU  - Stojanović, Boban
AU  - Trajković, Vladimir
AU  - Uskoković, Dragan
AU  - Uskoković, Petar S.
AU  - Veljković, Dejan
AU  - Vlastelica, Ivo
AU  - Vunjak Novaković, Gordana
PY  - 2010
UR  - http://dais.sanu.ac.rs/123456789/121
AB  - Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi.
Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci.
Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti.
Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.
PB  - Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala
T1  - Biomaterijali
ER  - 
@book{
author = "Balać, Igor and Bugarski, Branko and Ćosić, Irena and Dramićanin, Miroslav and Đorđević, Drago and Filipović, Nenad D. and Ignjatović, Nenad and Janaćković, Đorđe and Kojić, Miloš and Manojlović, Verica and Marković, Zoran and Obradović, Bojana and Pajić Lijaković, Ivana and Pavlović, Miodrag and Plavšić, Milenko and Raković, Dejan and Ranković, Vladimir and Stojanović, Boban and Trajković, Vladimir and Uskoković, Dragan and Uskoković, Petar S. and Veljković, Dejan and Vlastelica, Ivo and Vunjak Novaković, Gordana",
year = "2010",
url = "http://dais.sanu.ac.rs/123456789/121",
abstract = "Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi.
Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci.
Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti.
Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.",
publisher = "Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala",
title = "Biomaterijali"
}
Balać, I., Bugarski, B., Ćosić, I., Dramićanin, M., Đorđević, D., Filipović, N. D., Ignjatović, N., Janaćković, Đ., Kojić, M., Manojlović, V., Marković, Z., Obradović, B., Pajić Lijaković, I., Pavlović, M., Plavšić, M., Raković, D., Ranković, V., Stojanović, B., Trajković, V., Uskoković, D., Uskoković, P. S., Veljković, D., Vlastelica, I.,& Vunjak Novaković, G. (2010). Biomaterijali.
nullBeograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala., null. 
Balać I, Bugarski B, Ćosić I, Dramićanin M, Đorđević D, Filipović ND, Ignjatović N, Janaćković Đ, Kojić M, Manojlović V, Marković Z, Obradović B, Pajić Lijaković I, Pavlović M, Plavšić M, Raković D, Ranković V, Stojanović B, Trajković V, Uskoković D, Uskoković PS, Veljković D, Vlastelica I, Vunjak Novaković G. Biomaterijali. 2010;

Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation

Najman, Stevo; Đorđević, Lj.; Savić, Vojin; Ignjatović, Nenad; Plavšić, Milenko; Uskoković, Dragan

(Niš : University of Niš, 2003)

TY  - JOUR
AU  - Najman, Stevo
AU  - Đorđević, Lj.
AU  - Savić, Vojin
AU  - Ignjatović, Nenad
AU  - Plavšić, Milenko
AU  - Uskoković, Dragan
PY  - 2003
UR  - http://www.ncbi.nlm.nih.gov/pubmed/0354-21170303131N
UR  - http://dais.sanu.ac.rs/123456789/3361
AB  - Experimental and clinical studies have shown that HAp granules and powder may be successfully applied in reconstruction of bone defects. Composite HAp/PLLA biomaterial embodies good characteristics of each of these biomaterials. Differences in porosity, microstructure, compressive consistency as well as in bioresorbility of HAp/PLLA are achieved by using PLLA of different mole masses. The aim of this study was to analyse light microscopy of the tissue reaction and changes of implants made of combination of syngeneic bone fragments and HAp/PLLA biocomposites with PLLA molecule mass of 430 000 (HP2) and 50 000 (HP3). The mice were divided into 4 experimental studies, 8 animals each. Two groups underwent implantation one group of mice was falsely operated, and one group was used for general control. Pathohistological analysis of implants was performed three months after subcutaneous implantation. Phagocytosis of HAp/ PLLA and bone was noticed on both implants’ preparations. Blood vessels were also noticed confirming the process of angiogenesis around the implants’ particles. The holes around particles of biocomposites and bone fragments represented the signs of their resorption. The presence of multinuclear cells between implants’ particles was observed and it was more prominent in HP3 implants. Osteogenesis is more intense in HP3 and ectopic hematopoesis is present. Our results show that designed HAp/PLLA biocomposites have good biocompatibility, their combination with bone fragments of a vital bone enables osteogenesis and hematopoesis and these processes are more prominent if PLLA biocomposite with lower molecular mass was used.
PB  - Niš : University of Niš
T2  - Facta universitatis - series: Medicine and Biology
T1  - Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation
SP  - 131
EP  - 134
VL  - 10
IS  - 3
ER  - 
@article{
author = "Najman, Stevo and Đorđević, Lj. and Savić, Vojin and Ignjatović, Nenad and Plavšić, Milenko and Uskoković, Dragan",
year = "2003",
url = "http://www.ncbi.nlm.nih.gov/pubmed/0354-21170303131N, http://dais.sanu.ac.rs/123456789/3361",
abstract = "Experimental and clinical studies have shown that HAp granules and powder may be successfully applied in reconstruction of bone defects. Composite HAp/PLLA biomaterial embodies good characteristics of each of these biomaterials. Differences in porosity, microstructure, compressive consistency as well as in bioresorbility of HAp/PLLA are achieved by using PLLA of different mole masses. The aim of this study was to analyse light microscopy of the tissue reaction and changes of implants made of combination of syngeneic bone fragments and HAp/PLLA biocomposites with PLLA molecule mass of 430 000 (HP2) and 50 000 (HP3). The mice were divided into 4 experimental studies, 8 animals each. Two groups underwent implantation one group of mice was falsely operated, and one group was used for general control. Pathohistological analysis of implants was performed three months after subcutaneous implantation. Phagocytosis of HAp/ PLLA and bone was noticed on both implants’ preparations. Blood vessels were also noticed confirming the process of angiogenesis around the implants’ particles. The holes around particles of biocomposites and bone fragments represented the signs of their resorption. The presence of multinuclear cells between implants’ particles was observed and it was more prominent in HP3 implants. Osteogenesis is more intense in HP3 and ectopic hematopoesis is present. Our results show that designed HAp/PLLA biocomposites have good biocompatibility, their combination with bone fragments of a vital bone enables osteogenesis and hematopoesis and these processes are more prominent if PLLA biocomposite with lower molecular mass was used.",
publisher = "Niš : University of Niš",
journal = "Facta universitatis - series: Medicine and Biology",
title = "Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation",
pages = "131-134",
volume = "10",
number = "3"
}
Najman, S., Đorđević, Lj., Savić, V., Ignjatović, N., Plavšić, M.,& Uskoković, D. (2003). Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation.
Facta universitatis - series: Medicine and BiologyNiš : University of Niš., 10(3), 131-134. 
Najman S, Đorđević L, Savić V, Ignjatović N, Plavšić M, Uskoković D. Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation. Facta universitatis - series: Medicine and Biology. 2003;10(3):131-134

Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy

Ignjatović, Nenad; Plavšić, Milenko; Najman, Stevo; Savić, Vojin; Uskoković, Dragan

(Uetikon-Zuerich : Trans Tech Publ, 2000)

TY  - CONF
AU  - Ignjatović, Nenad
AU  - Plavšić, Milenko
AU  - Najman, Stevo
AU  - Savić, Vojin
AU  - Uskoković, Dragan
PY  - 2000
UR  - http://dais.sanu.ac.rs/123456789/3859
AB  - Hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial with PLLA of 50,000 and 430,000 g/mole molecular weight was studied in vivo. The biocomposite with PLLA of both molecular weights was implanted into mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After one week of testing in vivo, the implanted samples gave spectra in which absorption bands arising from new-formed functional groups of amine and peptide can be seen. Analysis of the spectra revealed faster formation of peptide compounds when the biocomposite with PLLA of lower molecular weight was used. After 3 weeks, the spectra of the biocomposite of both compositions were registered with pronounced absorption bands at about 3420 and 1650 cm-1 assigned to new-generated collagen, a component of the extracellular connective-tissue matrix. Also, in the case of the biocomposite sample with PLLA of lower molecular weight, disappearance of the previously present absorption band at about 1760 cm-1 originating from the C double bond O group of PLLA indicates complete bioresorption of the PLLA used. Analysis of the microstructures of the sample surfaces by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase in the system with PLLA of lower molecular weight and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial alone were found.
PB  - Uetikon-Zuerich : Trans Tech Publ
C3  - Trends in Advanced Materials and Processes
T1  - Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy
SP  - 143
EP  - 150
ER  - 
@conference{
author = "Ignjatović, Nenad and Plavšić, Milenko and Najman, Stevo and Savić, Vojin and Uskoković, Dragan",
year = "2000",
url = "http://dais.sanu.ac.rs/123456789/3859",
abstract = "Hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial with PLLA of 50,000 and 430,000 g/mole molecular weight was studied in vivo. The biocomposite with PLLA of both molecular weights was implanted into mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After one week of testing in vivo, the implanted samples gave spectra in which absorption bands arising from new-formed functional groups of amine and peptide can be seen. Analysis of the spectra revealed faster formation of peptide compounds when the biocomposite with PLLA of lower molecular weight was used. After 3 weeks, the spectra of the biocomposite of both compositions were registered with pronounced absorption bands at about 3420 and 1650 cm-1 assigned to new-generated collagen, a component of the extracellular connective-tissue matrix. Also, in the case of the biocomposite sample with PLLA of lower molecular weight, disappearance of the previously present absorption band at about 1760 cm-1 originating from the C double bond O group of PLLA indicates complete bioresorption of the PLLA used. Analysis of the microstructures of the sample surfaces by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase in the system with PLLA of lower molecular weight and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial alone were found.",
publisher = "Uetikon-Zuerich : Trans Tech Publ",
journal = "Trends in Advanced Materials and Processes",
title = "Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy",
pages = "143-150"
}
Ignjatović, N., Plavšić, M., Najman, S., Savić, V.,& Uskoković, D. (2000). Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy.
Trends in Advanced Materials and ProcessesUetikon-Zuerich : Trans Tech Publ., null, 143-150. 
Ignjatović N, Plavšić M, Najman S, Savić V, Uskoković D. Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy. Trends in Advanced Materials and Processes. 2000;:143-150
13

Hydroxyapatite/poly-L-lactide (Collagen) biocomposite with poly-L-lactide of different molecular weights

Ignjatović, Nenad; Plavšić, Milenko; Uskoković, Dragan

(Weinheim : Wiley-VCH Verlag, 2000)

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Plavšić, Milenko
AU  - Uskoković, Dragan
PY  - 2000
UR  - http://dais.sanu.ac.rs/123456789/3863
AB  - In this communication we describe the preparation of HAp/PLLA biocomposites by hot pressing of HAp powder with PLLA of different molecular weights, with and without the addition of collagen. We made PLLA of low molecular weight and with molecular weight as high as possible. The most frequently used metal and polymer biomaterials, titanium and PTFE (Teflon), can be coated with HAp/PLLA biocomposite. HAp and PLLA are both bioactive, whereas PTFE is bioinert and titanium is less-bioactive.[16] In this way, the surface functionality of titanium and PTFE biomaterials can be changed and improved. A comparative analysis was also made of the stability of two types of HAp/PLLA biocomposite blocks in physiological solution at 37 °C for 80 days
PB  - Weinheim : Wiley-VCH Verlag
T2  - Advanced Engineering Materials
T1  - Hydroxyapatite/poly-L-lactide (Collagen) biocomposite with poly-L-lactide of different molecular weights
SP  - 511
EP  - 514
VL  - 2
IS  - 8
DO  - 10.1002/1527-2648(200008)2:8<511::AID-ADEM511>3.0.CO;2-B
ER  - 
@article{
author = "Ignjatović, Nenad and Plavšić, Milenko and Uskoković, Dragan",
year = "2000",
url = "http://dais.sanu.ac.rs/123456789/3863",
abstract = "In this communication we describe the preparation of HAp/PLLA biocomposites by hot pressing of HAp powder with PLLA of different molecular weights, with and without the addition of collagen. We made PLLA of low molecular weight and with molecular weight as high as possible. The most frequently used metal and polymer biomaterials, titanium and PTFE (Teflon), can be coated with HAp/PLLA biocomposite. HAp and PLLA are both bioactive, whereas PTFE is bioinert and titanium is less-bioactive.[16] In this way, the surface functionality of titanium and PTFE biomaterials can be changed and improved. A comparative analysis was also made of the stability of two types of HAp/PLLA biocomposite blocks in physiological solution at 37 °C for 80 days",
publisher = "Weinheim : Wiley-VCH Verlag",
journal = "Advanced Engineering Materials",
title = "Hydroxyapatite/poly-L-lactide (Collagen) biocomposite with poly-L-lactide of different molecular weights",
pages = "511-514",
volume = "2",
number = "8",
doi = "10.1002/1527-2648(200008)2:8<511::AID-ADEM511>3.0.CO;2-B"
}
Ignjatović, N., Plavšić, M.,& Uskoković, D. (2000). Hydroxyapatite/poly-L-lactide (Collagen) biocomposite with poly-L-lactide of different molecular weights.
Advanced Engineering MaterialsWeinheim : Wiley-VCH Verlag., 2(8), 511-514. 
https://doi.org/10.1002/1527-2648(200008)2:8<511::AID-ADEM511>3.0.CO;2-B
Ignjatović N, Plavšić M, Uskoković D. Hydroxyapatite/poly-L-lactide (Collagen) biocomposite with poly-L-lactide of different molecular weights. Advanced Engineering Materials. 2000;2(8):511-514
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