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Choi, Jonghoon

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  • Choi, Jonghoon (5)
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Author's Bibliography

Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality

Stevanović, Magdalena; Nunić, Jana; Choi, Jonghoon; Filipović, Miloš; Uskoković, Dragan; Tsotakos, Theodore; Fragogeorgi, Eirini; Psimadas, Dimitris; Palamaris, Lazaros; Loudos, George

(Belgrade : Materials Research Society of Serbia, 2014)

TY  - CONF
AU  - Stevanović, Magdalena
AU  - Nunić, Jana
AU  - Choi, Jonghoon
AU  - Filipović, Miloš
AU  - Uskoković, Dragan
AU  - Tsotakos, Theodore
AU  - Fragogeorgi, Eirini
AU  - Psimadas, Dimitris
AU  - Palamaris, Lazaros
AU  - Loudos, George
PY  - 2014
UR  - http://dais.sanu.ac.rs/123456789/584
AB  - Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
T1  - Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality
SP  - 38
EP  - 38
ER  - 
@conference{
author = "Stevanović, Magdalena and Nunić, Jana and Choi, Jonghoon and Filipović, Miloš and Uskoković, Dragan and Tsotakos, Theodore and Fragogeorgi, Eirini and Psimadas, Dimitris and Palamaris, Lazaros and Loudos, George",
year = "2014",
url = "http://dais.sanu.ac.rs/123456789/584",
abstract = "Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts",
title = "Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality",
pages = "38-38"
}
Stevanović, M., Nunić, J., Choi, J., Filipović, M., Uskoković, D., Tsotakos, T., Fragogeorgi, E., Psimadas, D., Palamaris, L.,& Loudos, G. (2014). Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality.
The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of AbstractsBelgrade : Materials Research Society of Serbia., null, 38-38. 
Stevanović M, Nunić J, Choi J, Filipović M, Uskoković D, Tsotakos T, Fragogeorgi E, Psimadas D, Palamaris L, Loudos G. Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality. The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts. 2014;:38-38

The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles

Stojanović, Zoran S.; Otoničar, Mojca; Lee, Jongwook; Stevanović, Magdalena; Hwang, Mintai P.; Lee, Hyi; Choi, Jonghoon; Uskoković, Dragan

(Elsevier, 2013)

TY  - JOUR
AU  - Stojanović, Zoran S.
AU  - Otoničar, Mojca
AU  - Lee, Jongwook
AU  - Stevanović, Magdalena
AU  - Hwang, Mintai P.
AU  - Lee, Hyi
AU  - Choi, Jonghoon
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/113
AB  - We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.
PB  - Elsevier
T2  - Colloids and Surfaces B: Biointerfaces
T1  - The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles
SP  - 236
EP  - 243
VL  - 109
DO  - 10.1016/j.colsurfb.2013.03.053
ER  - 
@article{
author = "Stojanović, Zoran S. and Otoničar, Mojca and Lee, Jongwook and Stevanović, Magdalena and Hwang, Mintai P. and Lee, Hyi and Choi, Jonghoon and Uskoković, Dragan",
year = "2013",
url = "http://dais.sanu.ac.rs/123456789/113",
abstract = "We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.",
publisher = "Elsevier",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles",
pages = "236-243",
volume = "109",
doi = "10.1016/j.colsurfb.2013.03.053"
}
Stojanović, Z. S., Otoničar, M., Lee, J., Stevanović, M., Hwang, M. P., Lee, H., Choi, J.,& Uskoković, D. (2013). The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles.
Colloids and Surfaces B: BiointerfacesElsevier., 109, 236-243. 
https://doi.org/10.1016/j.colsurfb.2013.03.053
Stojanović ZS, Otoničar M, Lee J, Stevanović M, Hwang MP, Lee H, Choi J, Uskoković D. The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles. Colloids and Surfaces B: Biointerfaces. 2013;109:236-243
12
14
15

The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles

Stojanović, Zoran S.; Otoničar, Mojca; Lee, Jongwook; Stevanović, Magdalena; Hwang, Mintai P.; Lee, Hyi; Choi, Jonghoon; Uskoković, Dragan

(2013)

TY  - JOUR
AU  - Stojanović, Zoran S.
AU  - Otoničar, Mojca
AU  - Lee, Jongwook
AU  - Stevanović, Magdalena
AU  - Hwang, Mintai P.
AU  - Lee, Hyi
AU  - Choi, Jonghoon
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/163
AB  - We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.
T2  - Colloids and Surfaces B: Biointerfaces
T1  - The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles
SP  - 236
EP  - 243
VL  - 109
DO  - 10.1016/j.colsurfb.2013.03.053
ER  - 
@article{
author = "Stojanović, Zoran S. and Otoničar, Mojca and Lee, Jongwook and Stevanović, Magdalena and Hwang, Mintai P. and Lee, Hyi and Choi, Jonghoon and Uskoković, Dragan",
year = "2013",
url = "http://dais.sanu.ac.rs/123456789/163",
abstract = "We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles",
pages = "236-243",
volume = "109",
doi = "10.1016/j.colsurfb.2013.03.053"
}
Stojanović, Z. S., Otoničar, M., Lee, J., Stevanović, M., Hwang, M. P., Lee, H., Choi, J.,& Uskoković, D. (2013). The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles.
Colloids and Surfaces B: Biointerfaces, 109, 236-243. 
https://doi.org/10.1016/j.colsurfb.2013.03.053
Stojanović ZS, Otoničar M, Lee J, Stevanović M, Hwang MP, Lee H, Choi J, Uskoković D. The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles. Colloids and Surfaces B: Biointerfaces. 2013;109:236-243
12
14
15

In vitro cell interaction and in vivo biodistribution of poly (dl-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles for the treatment of liver diseases

Stevanović, Magdalena; Nunić, Jana; Choi, Jonghoon; Filipović, Miloš; Uskoković, Dragan; Tsotakos, Theodore; Fragogeorgi, Eirini; Psimadas, Dimitris; Palamaris, Lazaros; Loudos, George

(Athens, 2013)

TY  - CONF
AU  - Stevanović, Magdalena
AU  - Nunić, Jana
AU  - Choi, Jonghoon
AU  - Filipović, Miloš
AU  - Uskoković, Dragan
AU  - Tsotakos, Theodore
AU  - Fragogeorgi, Eirini
AU  - Psimadas, Dimitris
AU  - Palamaris, Lazaros
AU  - Loudos, George
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/855
AB  - The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials [1, 2] suggesting that anti-tumor effect mechanisms of selenium include induction of apoptosis, inhibition of cell proliferation, protection against oxidative stress, and stimulation of immune system.
Herein we demonstrate a simple and quick synthesis of uniform, stable, amorphous selenium nanoparticles (SeNps), using ascorbic acid as the reduction agent. The choice of an appropriate stabilizer and reducing agent for preparation of stable selenium nanoparticles is very important. We used bovine serum albumin (BSA) as an organic layer for selenium nanoparticles, i.e., as a capping agent to make them more biocompatibile and protect them from agglomeration in the suspension medium.
SeNps were additionally encapsulated within spherical PLGA particles (PLGA/SeNps). One of the most important requirements for the controlled and balanced release of the drug in the body is ideal spherical shape of the particles and narrow distribution of their sizes. The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell.
The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. Synthesized nanoparticles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method [3]. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.

Acknowledgements
This study was supported by the Ministry of Science and Technological Development of the Republic of Serbia, under Grant No. III45004: Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them. Presented were the results of a study also supported by the COST Action TD1004.

References
1. Popova, N. V. Cancer Lett. 2002, 179, 39–42.
2. Li, S.; Zhou, Y.; Wang, R.; Zhang, H.; Dong, Y.; Ip, C. Mol. Cancer Ther. 2007, 6, 1031–1038.
3. Psimadas, D.; Baldi, G.; Ravagli, C.; Bouziotis, P.; Xanthopoulos, S.; Francini, M.; Georgoulias, P.; Loudos, G.; J. Biom. Nan., 2012, 8, 4, 575-585.
PB  - Athens
C3  - Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery: COST TD1004 Action, Annual Meeting, September 1st- September 3rd, 2013
T1  - In vitro cell interaction and in vivo biodistribution of poly (dl-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles for the treatment of liver diseases
ER  - 
@conference{
author = "Stevanović, Magdalena and Nunić, Jana and Choi, Jonghoon and Filipović, Miloš and Uskoković, Dragan and Tsotakos, Theodore and Fragogeorgi, Eirini and Psimadas, Dimitris and Palamaris, Lazaros and Loudos, George",
year = "2013",
url = "http://dais.sanu.ac.rs/123456789/855",
abstract = "The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials [1, 2] suggesting that anti-tumor effect mechanisms of selenium include induction of apoptosis, inhibition of cell proliferation, protection against oxidative stress, and stimulation of immune system.
Herein we demonstrate a simple and quick synthesis of uniform, stable, amorphous selenium nanoparticles (SeNps), using ascorbic acid as the reduction agent. The choice of an appropriate stabilizer and reducing agent for preparation of stable selenium nanoparticles is very important. We used bovine serum albumin (BSA) as an organic layer for selenium nanoparticles, i.e., as a capping agent to make them more biocompatibile and protect them from agglomeration in the suspension medium.
SeNps were additionally encapsulated within spherical PLGA particles (PLGA/SeNps). One of the most important requirements for the controlled and balanced release of the drug in the body is ideal spherical shape of the particles and narrow distribution of their sizes. The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell.
The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. Synthesized nanoparticles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method [3]. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.

Acknowledgements
This study was supported by the Ministry of Science and Technological Development of the Republic of Serbia, under Grant No. III45004: Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them. Presented were the results of a study also supported by the COST Action TD1004.

References
1. Popova, N. V. Cancer Lett. 2002, 179, 39–42.
2. Li, S.; Zhou, Y.; Wang, R.; Zhang, H.; Dong, Y.; Ip, C. Mol. Cancer Ther. 2007, 6, 1031–1038.
3. Psimadas, D.; Baldi, G.; Ravagli, C.; Bouziotis, P.; Xanthopoulos, S.; Francini, M.; Georgoulias, P.; Loudos, G.; J. Biom. Nan., 2012, 8, 4, 575-585.",
publisher = "Athens",
journal = "Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery: COST TD1004 Action, Annual Meeting, September 1st- September 3rd, 2013",
title = "In vitro cell interaction and in vivo biodistribution of poly (dl-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles for the treatment of liver diseases"
}
Stevanović, M., Nunić, J., Choi, J., Filipović, M., Uskoković, D., Tsotakos, T., Fragogeorgi, E., Psimadas, D., Palamaris, L.,& Loudos, G. (2013). In vitro cell interaction and in vivo biodistribution of poly (dl-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles for the treatment of liver diseases.
Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery: COST TD1004 Action, Annual Meeting, September 1st- September 3rd, 2013Athens., null. 
Stevanović M, Nunić J, Choi J, Filipović M, Uskoković D, Tsotakos T, Fragogeorgi E, Psimadas D, Palamaris L, Loudos G. In vitro cell interaction and in vivo biodistribution of poly (dl-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles for the treatment of liver diseases. Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery: COST TD1004 Action, Annual Meeting, September 1st- September 3rd, 2013. 2013;

Facile Solvothermal Preparation of Monodisperse Gold Nanoparticles and Their Engineered Assembly of Ferritin–Gold Nanoclusters

Choi, Jonghoon; Park, Sungwook; Stojanović, Zoran S.; Han, Hyung-Seop; Lee, Jongwook; Seok, Hyun Kwang; Uskoković, Dragan; Lee, Kwan Hyi

(Elsevier, 2013)

TY  - JOUR
AU  - Choi, Jonghoon
AU  - Park, Sungwook
AU  - Stojanović, Zoran S.
AU  - Han, Hyung-Seop
AU  - Lee, Jongwook
AU  - Seok, Hyun Kwang
AU  - Uskoković, Dragan
AU  - Lee, Kwan Hyi
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/343
AB  - Herein, we report a quick and simple synthesis of water-soluble gold nanoparticles using a HAuCl4 and oleylamine mixture. Oleylamine serves as a reduction agent as well as a stabilizer for nanoparticle surfaces. The particle sizes can be adjusted by modulating reaction temperature and time. Solvothermal reduction of HAuCl4 with oleylamine can be confirmed by measuring the product in Fourier transform infrared (FTIR) spectroscopy. The plasmon band shifting from yellow to red confirms a nanosized particle formation. Amide bonds on the surface of the nanoparticles formed hydrogen bonds with one another, resulting in a hydrophobic monolayer. Particles dispersed well in nonpolar organic solvents, such as in hexane or toluene, by brief sonication. Next, we demonstrated the transfer of gold nanoparticles into water by lipid capsulation using 1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine (MHPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy polyethylene glycol)-2000 (DPPE-PEG2k), and 1,2-dioleoyl-sn-glycero-3-N-{5-amino-1-carboxypentyl}iminodiacetic acid succinyl nickel salt [DGS-NTA(Ni)]. The particle concentration can be obtained using an absorbance in ultraviolet–visible (UV–vis) spectra (at 420 nm). Instrumental analyses using transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) analysis, dynamic light scattering (DLS), and FTIR confirmed successful production of gold nanoparticles and fair solubility in water. Prepared gold particles were selectively clustered via engineered ferritin nanocages that provide multiple conjugation moieties. A total of 5–6 gold nanoparticles were clustered on a single ferritin nanocage confirmed in TEM. Reported solvothermal synthesis and preparation of gold nanoclusters may serve as an efficient, alternate way of preparing water-soluble gold nanoparticles, which can be used in a wide variety of biomedical applications.
PB  - Elsevier
T2  - Langmuir
T1  - Facile Solvothermal Preparation of Monodisperse Gold Nanoparticles and Their Engineered Assembly of Ferritin–Gold Nanoclusters
SP  - 15698
EP  - 15703
VL  - 29
IS  - 50
DO  - 10.1021/la403888f
ER  - 
@article{
author = "Choi, Jonghoon and Park, Sungwook and Stojanović, Zoran S. and Han, Hyung-Seop and Lee, Jongwook and Seok, Hyun Kwang and Uskoković, Dragan and Lee, Kwan Hyi",
year = "2013",
url = "http://dais.sanu.ac.rs/123456789/343",
abstract = "Herein, we report a quick and simple synthesis of water-soluble gold nanoparticles using a HAuCl4 and oleylamine mixture. Oleylamine serves as a reduction agent as well as a stabilizer for nanoparticle surfaces. The particle sizes can be adjusted by modulating reaction temperature and time. Solvothermal reduction of HAuCl4 with oleylamine can be confirmed by measuring the product in Fourier transform infrared (FTIR) spectroscopy. The plasmon band shifting from yellow to red confirms a nanosized particle formation. Amide bonds on the surface of the nanoparticles formed hydrogen bonds with one another, resulting in a hydrophobic monolayer. Particles dispersed well in nonpolar organic solvents, such as in hexane or toluene, by brief sonication. Next, we demonstrated the transfer of gold nanoparticles into water by lipid capsulation using 1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine (MHPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy polyethylene glycol)-2000 (DPPE-PEG2k), and 1,2-dioleoyl-sn-glycero-3-N-{5-amino-1-carboxypentyl}iminodiacetic acid succinyl nickel salt [DGS-NTA(Ni)]. The particle concentration can be obtained using an absorbance in ultraviolet–visible (UV–vis) spectra (at 420 nm). Instrumental analyses using transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) analysis, dynamic light scattering (DLS), and FTIR confirmed successful production of gold nanoparticles and fair solubility in water. Prepared gold particles were selectively clustered via engineered ferritin nanocages that provide multiple conjugation moieties. A total of 5–6 gold nanoparticles were clustered on a single ferritin nanocage confirmed in TEM. Reported solvothermal synthesis and preparation of gold nanoclusters may serve as an efficient, alternate way of preparing water-soluble gold nanoparticles, which can be used in a wide variety of biomedical applications.",
publisher = "Elsevier",
journal = "Langmuir",
title = "Facile Solvothermal Preparation of Monodisperse Gold Nanoparticles and Their Engineered Assembly of Ferritin–Gold Nanoclusters",
pages = "15698-15703",
volume = "29",
number = "50",
doi = "10.1021/la403888f"
}
Choi, J., Park, S., Stojanović, Z. S., Han, H., Lee, J., Seok, H. K., Uskoković, D.,& Lee, K. H. (2013). Facile Solvothermal Preparation of Monodisperse Gold Nanoparticles and Their Engineered Assembly of Ferritin–Gold Nanoclusters.
LangmuirElsevier., 29(50), 15698-15703. 
https://doi.org/10.1021/la403888f
Choi J, Park S, Stojanović ZS, Han H, Lee J, Seok HK, Uskoković D, Lee KH. Facile Solvothermal Preparation of Monodisperse Gold Nanoparticles and Their Engineered Assembly of Ferritin–Gold Nanoclusters. Langmuir. 2013;29(50):15698-15703
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