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Sengottuvelan, Abirami

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Coated calcium phosphate scaffolds for bone tissue engineering produced by foam replica method

Filipović, Nenad; Lukić, Miodrag J.; Sengottuvelan, Abirami; Kaišarević, Sonja

(Belgrade : Institute of Technical Sciences of SASA, 2015)

TY  - CONF
AU  - Filipović, Nenad
AU  - Lukić, Miodrag J.
AU  - Sengottuvelan, Abirami
AU  - Kaišarević, Sonja
PY  - 2015
UR  - http://dais.sanu.ac.rs/123456789/833
AB  - Tissue engineering (TE) is a growing field which provides helpful alternative strategies for conventional treatments in medicine. TE involves the smart combination of cells, biomolecules and engineered porous biomaterials in the form of 3D scaffolds. When it comes to bone regeneration the use of 3D scaffolds made of calcium phosphate is a well-known concept with a great potential. Here we present the foam replica method as a procedure suitable for producing highly porous scaffolds with the pore size in the range of 100-500 μm and the mean porosity of >90%. The obtained scaffolds were further coated with selenium nanoparticles (SeNp) and SeNp immobilized within poly(epsilon caprolactone) microspheres (PCL/Se). The purpose of such coating is based on the potential anticancer activity of SeNp as well as on their prolonged release from a biodegradable polymeric carrier. Scaffolds were characterized by X-ray diffraction, scanning electron microscopy, optical microscopy, thermogravimetric/differential thermal analysis (TGA-DTA) as well as Fourier transform infrared spectroscopy (FTIR). The cytotoxicity was determined employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and all the samples have shown good biocompatibility. Based on these preliminary results the obtained system can be considered as a candidate for the repair of bone lesions and damages.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, Serbia
T1  - Coated calcium phosphate scaffolds for bone tissue engineering produced by foam replica method
SP  - 3
EP  - 3
ER  - 
@conference{
author = "Filipović, Nenad and Lukić, Miodrag J. and Sengottuvelan, Abirami and Kaišarević, Sonja",
year = "2015",
url = "http://dais.sanu.ac.rs/123456789/833",
abstract = "Tissue engineering (TE) is a growing field which provides helpful alternative strategies for conventional treatments in medicine. TE involves the smart combination of cells, biomolecules and engineered porous biomaterials in the form of 3D scaffolds. When it comes to bone regeneration the use of 3D scaffolds made of calcium phosphate is a well-known concept with a great potential. Here we present the foam replica method as a procedure suitable for producing highly porous scaffolds with the pore size in the range of 100-500 μm and the mean porosity of >90%. The obtained scaffolds were further coated with selenium nanoparticles (SeNp) and SeNp immobilized within poly(epsilon caprolactone) microspheres (PCL/Se). The purpose of such coating is based on the potential anticancer activity of SeNp as well as on their prolonged release from a biodegradable polymeric carrier. Scaffolds were characterized by X-ray diffraction, scanning electron microscopy, optical microscopy, thermogravimetric/differential thermal analysis (TGA-DTA) as well as Fourier transform infrared spectroscopy (FTIR). The cytotoxicity was determined employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and all the samples have shown good biocompatibility. Based on these preliminary results the obtained system can be considered as a candidate for the repair of bone lesions and damages.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, Serbia",
title = "Coated calcium phosphate scaffolds for bone tissue engineering produced by foam replica method",
pages = "3-3"
}
Filipović, N., Lukić, M. J., Sengottuvelan, A.,& Kaišarević, S. (2015). Coated calcium phosphate scaffolds for bone tissue engineering produced by foam replica method.
Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, SerbiaBelgrade : Institute of Technical Sciences of SASA., null, 3-3. 
Filipović N, Lukić MJ, Sengottuvelan A, Kaišarević S. Coated calcium phosphate scaffolds for bone tissue engineering produced by foam replica method. Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, Serbia. 2015;:3-3