TY  - JOUR
AU  - Guševac Stojanović, Ivana
AU  - Drakulić, Dunja
AU  - Todorović, Ana
AU  - Martinović, Jelena
AU  - Filipović, Nenad
AU  - Stojanović, Zoran
PY  - 2024
UR  - https://dais.sanu.ac.rs/123456789/16514
AB  - While the effects of chronic exposure to microplastic particles (MPs) are extensively studied, the outcomes of a single treatment have received relatively less attention. To investigate MPs’ potential acute toxicity, including their impact on general health status (victual consumption, sensorimotor deficits, and clinical toxicity signs) and serum biochemical parameters (markers of organ/tissue function and oxidative stress indicators), we administered thoroughly characterized MPs (1.4, 35, or 125 mg/kg), generated from polyethylene terephthalate (PET) bottles, to adult male Wistar rats via oral gavage. The MPs’ short-term effects were assessed with well-established tests and methods. The results point to the absence of sensorimotor deficits and clinical toxicity signs, while levels of markers of liver, heart, and kidney function were altered in all MP groups. Decreased victual consumption and increased levels of oxidative stress indicators were evident following treatment with the two higher MP doses. Presented data indicate that examined MPs are able to initiate the development of local changes in tissues and organs within a short time frame, potentially leading to their damage and dysfunction. This study may increase the awareness of the detrimental effects of plastic contamination, as even a single exposure to MPs may provoke adverse health outcomes.
PB  - Basel : MDPI AG
T2  - Toxics
T1  - Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats
SP  - 167
VL  - 12
IS  - 3
DO  - 10.3390/toxics12030167
UR  - https://hdl.handle.net/21.15107/rcub_dais_16514
ER  - 

@article{
author = "Guševac Stojanović, Ivana and Drakulić, Dunja and Todorović, Ana and Martinović, Jelena and Filipović, Nenad and Stojanović, Zoran",
year = "2024",
abstract = "While the effects of chronic exposure to microplastic particles (MPs) are extensively studied, the outcomes of a single treatment have received relatively less attention. To investigate MPs’ potential acute toxicity, including their impact on general health status (victual consumption, sensorimotor deficits, and clinical toxicity signs) and serum biochemical parameters (markers of organ/tissue function and oxidative stress indicators), we administered thoroughly characterized MPs (1.4, 35, or 125 mg/kg), generated from polyethylene terephthalate (PET) bottles, to adult male Wistar rats via oral gavage. The MPs’ short-term effects were assessed with well-established tests and methods. The results point to the absence of sensorimotor deficits and clinical toxicity signs, while levels of markers of liver, heart, and kidney function were altered in all MP groups. Decreased victual consumption and increased levels of oxidative stress indicators were evident following treatment with the two higher MP doses. Presented data indicate that examined MPs are able to initiate the development of local changes in tissues and organs within a short time frame, potentially leading to their damage and dysfunction. This study may increase the awareness of the detrimental effects of plastic contamination, as even a single exposure to MPs may provoke adverse health outcomes.",
publisher = "Basel : MDPI AG",
journal = "Toxics",
title = "Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats",
pages = "167",
volume = "12",
number = "3",
doi = "10.3390/toxics12030167",
url = "https://hdl.handle.net/21.15107/rcub_dais_16514"
}

Guševac Stojanović, I., Drakulić, D., Todorović, A., Martinović, J., Filipović, N.,& Stojanović, Z.. (2024). Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats. in Toxics
Basel : MDPI AG., 12(3), 167.
https://doi.org/10.3390/toxics12030167
https://hdl.handle.net/21.15107/rcub_dais_16514

Guševac Stojanović I, Drakulić D, Todorović A, Martinović J, Filipović N, Stojanović Z. Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats. in Toxics. 2024;12(3):167.
doi:10.3390/toxics12030167
https://hdl.handle.net/21.15107/rcub_dais_16514 .

Guševac Stojanović, Ivana, Drakulić, Dunja, Todorović, Ana, Martinović, Jelena, Filipović, Nenad, Stojanović, Zoran, "Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats" in Toxics, 12, no. 3 (2024):167,
https://doi.org/10.3390/toxics12030167 .,
https://hdl.handle.net/21.15107/rcub_dais_16514 .

TY  - CONF
AU  - Aleksić, Katarina
AU  - Bajić, Danica
AU  - Stojanović, Zoran
AU  - Latinović, Luka
AU  - Tomašević, Vladimir
AU  - Stojković Simatović, Ivana
AU  - Marković, Smilja
PY  - 2023
UR  - https://www.eurocorr2023.org/
UR  - https://dais.sanu.ac.rs/123456789/16171
AB  - Recently we have developed polymer/ceramic composite coatings based on poly(vinyl butyral), hydroxyapatite and zinc oxide-based nanostructured powders (PVB, HAP:Co and ZnO:Co, respectively). Prepared composite coatings showed good both adhesions to metal and glass surfaces and camouflage properties, thus can be used to improve combat capability of military equipment. An essential demand of new materials in the military industry is to be multifunctional.
Accordingly, the aim of this study was to examine corrosion activity of the PVB/ZnO:Co and PVB/HAP:Co coatings in saline solution as a function of immersion time. The ZnO:Co and HAP:Co nanostructured powders were synthesized by hydrothermal processing of a precipitate. To adjust optical properties, synthesized powders were annealed at 400, 800 and 1000 °C. Annealed powders were mixed with PVB: each powder was dispersed in ethanol with the aid of an ultrasonic probe, successively PVB powder was added in dispersion, in 10 wt.% regard to ethanol, and stirred on a mechanical stirrer to completely dissolve. Prepared solution was coated on stainless steel substrate and dried at room temperature for 72 hours to form solid coating. The corrosion activity of the coatings was measured by potentiodynamic polarization technique in the potential range from -0.8 to -0.2 V vs SCE, with the scan rate of 10mVs-1. The measurements were performed using a conventional three-electrode cell in 3% NaCl water solution as the electrolyte. Platinum foil, a standard calomel electrode (SCE) and coated stainless steel were used as the counter, reference and working electrode, respectively. We found that all examined coatings have lower corrosion activity than bare stainless steel or stainless steel coated with pure PVB. Differences in corrosion activity between the coatings are explained by different textural and optoelectronic properties of ceramic powders modified by the annealing procedure.
PB  - European Federation of Corrosion
C3  - EUROCORR2023 : The Annual Congress of the European Federation of Corrosion, August 27-31, 2023, Brussels, Belgium (EFC Event number 459)
T1  - Anti-corrosive composite coatings based on PVB/ZnO:Co and PVB/HAP:Co
UR  - https://hdl.handle.net/21.15107/rcub_dais_16171
ER  - 

@conference{
author = "Aleksić, Katarina and Bajić, Danica and Stojanović, Zoran and Latinović, Luka and Tomašević, Vladimir and Stojković Simatović, Ivana and Marković, Smilja",
year = "2023",
abstract = "Recently we have developed polymer/ceramic composite coatings based on poly(vinyl butyral), hydroxyapatite and zinc oxide-based nanostructured powders (PVB, HAP:Co and ZnO:Co, respectively). Prepared composite coatings showed good both adhesions to metal and glass surfaces and camouflage properties, thus can be used to improve combat capability of military equipment. An essential demand of new materials in the military industry is to be multifunctional.
Accordingly, the aim of this study was to examine corrosion activity of the PVB/ZnO:Co and PVB/HAP:Co coatings in saline solution as a function of immersion time. The ZnO:Co and HAP:Co nanostructured powders were synthesized by hydrothermal processing of a precipitate. To adjust optical properties, synthesized powders were annealed at 400, 800 and 1000 °C. Annealed powders were mixed with PVB: each powder was dispersed in ethanol with the aid of an ultrasonic probe, successively PVB powder was added in dispersion, in 10 wt.% regard to ethanol, and stirred on a mechanical stirrer to completely dissolve. Prepared solution was coated on stainless steel substrate and dried at room temperature for 72 hours to form solid coating. The corrosion activity of the coatings was measured by potentiodynamic polarization technique in the potential range from -0.8 to -0.2 V vs SCE, with the scan rate of 10mVs-1. The measurements were performed using a conventional three-electrode cell in 3% NaCl water solution as the electrolyte. Platinum foil, a standard calomel electrode (SCE) and coated stainless steel were used as the counter, reference and working electrode, respectively. We found that all examined coatings have lower corrosion activity than bare stainless steel or stainless steel coated with pure PVB. Differences in corrosion activity between the coatings are explained by different textural and optoelectronic properties of ceramic powders modified by the annealing procedure.",
publisher = "European Federation of Corrosion",
journal = "EUROCORR2023 : The Annual Congress of the European Federation of Corrosion, August 27-31, 2023, Brussels, Belgium (EFC Event number 459)",
title = "Anti-corrosive composite coatings based on PVB/ZnO:Co and PVB/HAP:Co",
url = "https://hdl.handle.net/21.15107/rcub_dais_16171"
}

Aleksić, K., Bajić, D., Stojanović, Z., Latinović, L., Tomašević, V., Stojković Simatović, I.,& Marković, S.. (2023). Anti-corrosive composite coatings based on PVB/ZnO:Co and PVB/HAP:Co. in EUROCORR2023 : The Annual Congress of the European Federation of Corrosion, August 27-31, 2023, Brussels, Belgium (EFC Event number 459)
European Federation of Corrosion..
https://hdl.handle.net/21.15107/rcub_dais_16171

Aleksić K, Bajić D, Stojanović Z, Latinović L, Tomašević V, Stojković Simatović I, Marković S. Anti-corrosive composite coatings based on PVB/ZnO:Co and PVB/HAP:Co. in EUROCORR2023 : The Annual Congress of the European Federation of Corrosion, August 27-31, 2023, Brussels, Belgium (EFC Event number 459). 2023;.
https://hdl.handle.net/21.15107/rcub_dais_16171 .

Aleksić, Katarina, Bajić, Danica, Stojanović, Zoran, Latinović, Luka, Tomašević, Vladimir, Stojković Simatović, Ivana, Marković, Smilja, "Anti-corrosive composite coatings based on PVB/ZnO:Co and PVB/HAP:Co" in EUROCORR2023 : The Annual Congress of the European Federation of Corrosion, August 27-31, 2023, Brussels, Belgium (EFC Event number 459) (2023),
https://hdl.handle.net/21.15107/rcub_dais_16171 .

TY  - CONF
AU  - Stojanović, Zoran
AU  - Kuzmanović, Maja
AU  - Stevanović, Magdalena
PY  - 2023
UR  - https://dais.sanu.ac.rs/123456789/15763
AB  - Large language models (LLMs) like Generative pre-trained transformers (GPTs) emerged in past couple of years with increase of computational power. These models are used for various tasks in field of natural language processing, such as text classification, question answering and language translation. In this talk, research methodology, practical aspects and performance testing of fine – tuned LLMs, both commercial and open source in domain of materials synthesis, will be covered. So far, LLMs seems to have promising future in education, research and production only integrated with other chemistry tools, thus further development of integrated AI systems as well as LLMs is necessary to enhance performances and meet future demands.
PB  - Ljubljana : Inštitut za kovinske materiale in tehnologije
C3  - 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology
T1  - Fine-Tuning and Performance Testing of Pre-Trained Large Language Models for Applications in Domain of Biomedical Materials Synthesis
SP  - 78
EP  - 78
UR  - https://hdl.handle.net/21.15107/rcub_dais_15763
ER  - 

@conference{
author = "Stojanović, Zoran and Kuzmanović, Maja and Stevanović, Magdalena",
year = "2023",
abstract = "Large language models (LLMs) like Generative pre-trained transformers (GPTs) emerged in past couple of years with increase of computational power. These models are used for various tasks in field of natural language processing, such as text classification, question answering and language translation. In this talk, research methodology, practical aspects and performance testing of fine – tuned LLMs, both commercial and open source in domain of materials synthesis, will be covered. So far, LLMs seems to have promising future in education, research and production only integrated with other chemistry tools, thus further development of integrated AI systems as well as LLMs is necessary to enhance performances and meet future demands.",
publisher = "Ljubljana : Inštitut za kovinske materiale in tehnologije",
journal = "28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology",
title = "Fine-Tuning and Performance Testing of Pre-Trained Large Language Models for Applications in Domain of Biomedical Materials Synthesis",
pages = "78-78",
url = "https://hdl.handle.net/21.15107/rcub_dais_15763"
}

Stojanović, Z., Kuzmanović, M.,& Stevanović, M.. (2023). Fine-Tuning and Performance Testing of Pre-Trained Large Language Models for Applications in Domain of Biomedical Materials Synthesis. in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology
Ljubljana : Inštitut za kovinske materiale in tehnologije., 78-78.
https://hdl.handle.net/21.15107/rcub_dais_15763

Stojanović Z, Kuzmanović M, Stevanović M. Fine-Tuning and Performance Testing of Pre-Trained Large Language Models for Applications in Domain of Biomedical Materials Synthesis. in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology. 2023;:78-78.
https://hdl.handle.net/21.15107/rcub_dais_15763 .

Stojanović, Zoran, Kuzmanović, Maja, Stevanović, Magdalena, "Fine-Tuning and Performance Testing of Pre-Trained Large Language Models for Applications in Domain of Biomedical Materials Synthesis" in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology (2023):78-78,
https://hdl.handle.net/21.15107/rcub_dais_15763 .

TY  - CONF
AU  - Filipović, Nenad
AU  - Tomić, Nina
AU  - Kuzmanović, Maja
AU  - Stojanović, Zoran
AU  - Stevanović, Magdalena
PY  - 2023
UR  - https://dais.sanu.ac.rs/123456789/15762
AB  - Nanotechnology, as a most promising approach in material science, has resulted in numerous enhancements and breakthroughs in diverse scientific fields. One of the examples is selenium nanoparticles (SeNPs) which emerged as a new form with some improved properties compared to other Se forms. Among these properties, anticancer, antimicrobial, antioxidative, and reduced toxicity are the most interesting from the aspect of biomedical applications. Due to simplicity, short duration, scalability, and reproducibility, chemical reduction is a synthesis technique very often applied in SeNPs production. The choice of reducing agents, their molar ratio with a precursor, and the choice of stabilizing agents are recognized as determining parameters for the application efficiency of designed SeNPs.
This presentation includes an overview of the results of SeNPs obtained by the reduction of sodium selenite and stabilized with different agents. Furthermore, the effects of synthesis parameters on the properties of obtained particles (size, morphology, crystallinity, stability, surface chemistry) and biological activities such as antimicrobial, antioxidative, and cytotoxicity will be elaborate. In addition, some potential applications of SeNPs will be discussed, with particular reference to the results of in vivo experiments.
PB  - Ljubljana : Inštitut za kovinske materiale in tehnologije
C3  - 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology
T1  - Selenium nanoparticles: Effects of particle properties on biological activity
SP  - 32
EP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_dais_15762
ER  - 

@conference{
author = "Filipović, Nenad and Tomić, Nina and Kuzmanović, Maja and Stojanović, Zoran and Stevanović, Magdalena",
year = "2023",
abstract = "Nanotechnology, as a most promising approach in material science, has resulted in numerous enhancements and breakthroughs in diverse scientific fields. One of the examples is selenium nanoparticles (SeNPs) which emerged as a new form with some improved properties compared to other Se forms. Among these properties, anticancer, antimicrobial, antioxidative, and reduced toxicity are the most interesting from the aspect of biomedical applications. Due to simplicity, short duration, scalability, and reproducibility, chemical reduction is a synthesis technique very often applied in SeNPs production. The choice of reducing agents, their molar ratio with a precursor, and the choice of stabilizing agents are recognized as determining parameters for the application efficiency of designed SeNPs.
This presentation includes an overview of the results of SeNPs obtained by the reduction of sodium selenite and stabilized with different agents. Furthermore, the effects of synthesis parameters on the properties of obtained particles (size, morphology, crystallinity, stability, surface chemistry) and biological activities such as antimicrobial, antioxidative, and cytotoxicity will be elaborate. In addition, some potential applications of SeNPs will be discussed, with particular reference to the results of in vivo experiments.",
publisher = "Ljubljana : Inštitut za kovinske materiale in tehnologije",
journal = "28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology",
title = "Selenium nanoparticles: Effects of particle properties on biological activity",
pages = "32-32",
url = "https://hdl.handle.net/21.15107/rcub_dais_15762"
}

Filipović, N., Tomić, N., Kuzmanović, M., Stojanović, Z.,& Stevanović, M.. (2023). Selenium nanoparticles: Effects of particle properties on biological activity. in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology
Ljubljana : Inštitut za kovinske materiale in tehnologije., 32-32.
https://hdl.handle.net/21.15107/rcub_dais_15762

Filipović N, Tomić N, Kuzmanović M, Stojanović Z, Stevanović M. Selenium nanoparticles: Effects of particle properties on biological activity. in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology. 2023;:32-32.
https://hdl.handle.net/21.15107/rcub_dais_15762 .

Filipović, Nenad, Tomić, Nina, Kuzmanović, Maja, Stojanović, Zoran, Stevanović, Magdalena, "Selenium nanoparticles: Effects of particle properties on biological activity" in 28. Mednarodna konferenca o materialih in tehnologijah = 28th International Conference on Materials and Technology (2023):32-32,
https://hdl.handle.net/21.15107/rcub_dais_15762 .

TY  - CONF
AU  - Martinović, Jelena
AU  - Zarić Kontić, Marina
AU  - Guševac Stojanović, Ivana
AU  - Mitrović, Nataša
AU  - Grković, Ivana
AU  - Stojanović, Zoran
AU  - Drakulić, Dunja
AU  - Samardžić, Janko
PY  - 2023
UR  - https://dais.sanu.ac.rs/123456789/14565
AB  - Zaleplon, a member of Z-drugs, is a pyrazolopyrimidine hypnotic with sedative, anxiolytic, anticonvulsant and muscle relaxant properties. Zaleplon is approved for the short-term management of insomnia since acting as positive γ-aminobutyric acid (GABA) receptor allosteric modulator increases efficacy of inhibition on brain excitability. Importantly, for the proper functioning of the brain a balance between inhibitory (i.e., GABAergic) and excitatory (i.e., glutamatergic) system must be accomplished. This may be fulfilled by control of presynaptic elements (synthesis or degradation of glutamate and GABA neurotransmitters, their compartmentation, releasing and recycling) and regulation of expression and function of glutamate and GABA receptors. Hence, we aimed to investigate effects of prolonged zaleplon treatment on the expression of proteins involved in the gabaergic and glutamatergic signalization in the hippocampus of adult male Wistar rats. Five-day intraperitoneal administration increased level of components of GABAergic signalization (glutamate decarboxylase 67-GAD67, vesicular GABA transporter-VGAT and α1 subunit of GABA receptor-GABAAα1). This was accompanied by increased level of glutamatergic components (vesicular glutamate transporter 1-vGlut1 and subunits of glutamate N-Methyl-d-aspartate receptor-NMDAR, namely NR1, NR2A, NR2B), which clearly indicate maintenance of balance between main inhibitory and excitatory neurotransmitters. Given the importance of equilibrium of these systems for neuronal excitability, synaptic plasticity and cognitive functions, as well as its involvement in the mood, feeding behavior, reproductive functions, pain sensitivity, aging, etc., the current and prospective pharmaceuticals increasingly rely on GABA/glutamate balance
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats
SP  - 59
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11047
ER  - 

@conference{
author = "Martinović, Jelena and Zarić Kontić, Marina and Guševac Stojanović, Ivana and Mitrović, Nataša and Grković, Ivana and Stojanović, Zoran and Drakulić, Dunja and Samardžić, Janko",
year = "2023",
abstract = "Zaleplon, a member of Z-drugs, is a pyrazolopyrimidine hypnotic with sedative, anxiolytic, anticonvulsant and muscle relaxant properties. Zaleplon is approved for the short-term management of insomnia since acting as positive γ-aminobutyric acid (GABA) receptor allosteric modulator increases efficacy of inhibition on brain excitability. Importantly, for the proper functioning of the brain a balance between inhibitory (i.e., GABAergic) and excitatory (i.e., glutamatergic) system must be accomplished. This may be fulfilled by control of presynaptic elements (synthesis or degradation of glutamate and GABA neurotransmitters, their compartmentation, releasing and recycling) and regulation of expression and function of glutamate and GABA receptors. Hence, we aimed to investigate effects of prolonged zaleplon treatment on the expression of proteins involved in the gabaergic and glutamatergic signalization in the hippocampus of adult male Wistar rats. Five-day intraperitoneal administration increased level of components of GABAergic signalization (glutamate decarboxylase 67-GAD67, vesicular GABA transporter-VGAT and α1 subunit of GABA receptor-GABAAα1). This was accompanied by increased level of glutamatergic components (vesicular glutamate transporter 1-vGlut1 and subunits of glutamate N-Methyl-d-aspartate receptor-NMDAR, namely NR1, NR2A, NR2B), which clearly indicate maintenance of balance between main inhibitory and excitatory neurotransmitters. Given the importance of equilibrium of these systems for neuronal excitability, synaptic plasticity and cognitive functions, as well as its involvement in the mood, feeding behavior, reproductive functions, pain sensitivity, aging, etc., the current and prospective pharmaceuticals increasingly rely on GABA/glutamate balance",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats",
pages = "59",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11047"
}

Martinović, J., Zarić Kontić, M., Guševac Stojanović, I., Mitrović, N., Grković, I., Stojanović, Z., Drakulić, D.,& Samardžić, J.. (2023). Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 59.
https://hdl.handle.net/21.15107/rcub_vinar_11047

Martinović J, Zarić Kontić M, Guševac Stojanović I, Mitrović N, Grković I, Stojanović Z, Drakulić D, Samardžić J. Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:59.
https://hdl.handle.net/21.15107/rcub_vinar_11047 .

Martinović, Jelena, Zarić Kontić, Marina, Guševac Stojanović, Ivana, Mitrović, Nataša, Grković, Ivana, Stojanović, Zoran, Drakulić, Dunja, Samardžić, Janko, "Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):59,
https://hdl.handle.net/21.15107/rcub_vinar_11047 .

TY  - CONF
AU  - Guševac Stojanović, Ivana
AU  - Dragić, Milorad
AU  - Zarić Kontić, Marina
AU  - Martinović, Jelena
AU  - Mitrović, Nataša
AU  - Stojanović, Zoran
AU  - Veljković, Filip
AU  - Martinović, D.
AU  - Grković, Ivana
AU  - Drakulić, Dunja
PY  - 2023
UR  - https://dais.sanu.ac.rs/123456789/14702
AB  - Cerebral hypoperfusion (CH) is recognised as a contributor to various impairments characteristic for elderly population and patients with vascular dementia and Alzheimer’s disease. CH-induced brain damage is linked with oxidative stress in the cells that can cause DNA fragmentation and cell death, reflected through a change in cells’ morphology. Our study investigated the beneficial effects of progesterone (P4), a hormone with neuroprotective properties, against CH-induced oxidative stress and neurodegenerative pathologies in rat prefrontal cortex (PFC). For the purpose of the experiment, adult male Wistar rats were dived into groups: (I) animals subjected to permanent bilateral occlusion of common carotid arteries (2VO) treated with vehicle (commercial flax oil, 1 mg/kg/day), (II) animals subjected to 2VO treated with P4 dissolved in vehicle (1.7 mg/kg/day) and (III) animals subjected to sham operation treated with vehicle. Animals were sacrificed after 7 subcutaneous treatments. Levels of pro-/antioxidant balance (PAB) and DNA fragmentation along with cell morphology were estimated by well-defined methods. The results revealed that P4 administration moderated CH-induced impairments in PFC, not only by decreasing PAB level and diminishing DNA fragmentation, but also preserving the cell morphology reflected through clearly defined cell bodies, with round nuclei, prominent nucleolus and visible Nissl bodies in layer III. Obtained results point out that P4 is able to attenuate CH-induced pro-oxidant state and subsequent changes in PFC. This hormone holds promise as an effective agent for the CH treatment, still, its specific actions remain to be discovered.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Progesterone treatment preserves cortical pro-/antioxidant balance, DNA integrity and cell morphology in rat cerebral hypoperfusion model
SP  - 117
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11058
ER  - 

@conference{
author = "Guševac Stojanović, Ivana and Dragić, Milorad and Zarić Kontić, Marina and Martinović, Jelena and Mitrović, Nataša and Stojanović, Zoran and Veljković, Filip and Martinović, D. and Grković, Ivana and Drakulić, Dunja",
year = "2023",
abstract = "Cerebral hypoperfusion (CH) is recognised as a contributor to various impairments characteristic for elderly population and patients with vascular dementia and Alzheimer’s disease. CH-induced brain damage is linked with oxidative stress in the cells that can cause DNA fragmentation and cell death, reflected through a change in cells’ morphology. Our study investigated the beneficial effects of progesterone (P4), a hormone with neuroprotective properties, against CH-induced oxidative stress and neurodegenerative pathologies in rat prefrontal cortex (PFC). For the purpose of the experiment, adult male Wistar rats were dived into groups: (I) animals subjected to permanent bilateral occlusion of common carotid arteries (2VO) treated with vehicle (commercial flax oil, 1 mg/kg/day), (II) animals subjected to 2VO treated with P4 dissolved in vehicle (1.7 mg/kg/day) and (III) animals subjected to sham operation treated with vehicle. Animals were sacrificed after 7 subcutaneous treatments. Levels of pro-/antioxidant balance (PAB) and DNA fragmentation along with cell morphology were estimated by well-defined methods. The results revealed that P4 administration moderated CH-induced impairments in PFC, not only by decreasing PAB level and diminishing DNA fragmentation, but also preserving the cell morphology reflected through clearly defined cell bodies, with round nuclei, prominent nucleolus and visible Nissl bodies in layer III. Obtained results point out that P4 is able to attenuate CH-induced pro-oxidant state and subsequent changes in PFC. This hormone holds promise as an effective agent for the CH treatment, still, its specific actions remain to be discovered.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Progesterone treatment preserves cortical pro-/antioxidant balance, DNA integrity and cell morphology in rat cerebral hypoperfusion model",
pages = "117",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11058"
}

Guševac Stojanović, I., Dragić, M., Zarić Kontić, M., Martinović, J., Mitrović, N., Stojanović, Z., Veljković, F., Martinović, D., Grković, I.,& Drakulić, D.. (2023). Progesterone treatment preserves cortical pro-/antioxidant balance, DNA integrity and cell morphology in rat cerebral hypoperfusion model. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 117.
https://hdl.handle.net/21.15107/rcub_vinar_11058

Guševac Stojanović I, Dragić M, Zarić Kontić M, Martinović J, Mitrović N, Stojanović Z, Veljković F, Martinović D, Grković I, Drakulić D. Progesterone treatment preserves cortical pro-/antioxidant balance, DNA integrity and cell morphology in rat cerebral hypoperfusion model. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:117.
https://hdl.handle.net/21.15107/rcub_vinar_11058 .

Guševac Stojanović, Ivana, Dragić, Milorad, Zarić Kontić, Marina, Martinović, Jelena, Mitrović, Nataša, Stojanović, Zoran, Veljković, Filip, Martinović, D., Grković, Ivana, Drakulić, Dunja, "Progesterone treatment preserves cortical pro-/antioxidant balance, DNA integrity and cell morphology in rat cerebral hypoperfusion model" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):117,
https://hdl.handle.net/21.15107/rcub_vinar_11058 .

TY  - JOUR
AU  - Marković, Smilja
AU  - Rau, Julietta V.
AU  - De Bonis, Angela
AU  - De Bellis, Giovanni
AU  - Stojanović, Zoran
AU  - Veselinović, Ljiljana
AU  - Mitrić, Miodrag
AU  - Ignjatović, Nenad
AU  - Škapin, Srečo Davor
AU  - Vengust, Damjan
PY  - 2022
UR  - https://dais.sanu.ac.rs/123456789/12953
AB  - Dense calcium phosphate-based ceramics were fabricated to be used as targets for pulsed laser deposition (PLD). Nanostructured cobalt-substituted hydroxyapatite (Co:HAP) was used as a starting powder. To vary phase composition and microstructure of targets, two sintering approaches were applied, conventional (CS) and two-step sintering (TSS). The obtained results show that in both cases biphasic calcium phosphate (BCP) ceramics (targets) were prepared, with slightly different HAP-to-β–TCP amount ratio and a significantly different microstructure. While the CS method yielded fully dense ceramics with an average grain size of 1.3 μm, the ceramics prepared by TSS had a density of 98.5%, with a predominant grain size below 100 nm. (Ca + Co)P coatings were prepared by PLD of (Ca + Co)P targets. The temperature of the Ti substrate was adjusted to be 25 and 500 °C. The results show that the phase composition of (Ca + Co)P coatings depended on the phase composition of targets as well as on the temperature of the Ti substrate. The coating prepared at 25 °C using CS target consisted of three calcium phosphate phases, HAP, β–TCP and α–TCP; when the TSS target was used, the coating was biphasic, containing HAP and β–TCP. When the substrate was heated to 500 °C, regardless of whether the CS or the TSS target was used, the deposited coatings were composed of HAP and α–TCP. Due to different phase compositions, the (Ca + Co)P coatings deposited at 25 °C showed an improved hardness compared to those deposited at 500 °C. The obtained results confirmed that the phase composition, morphology and mechanical properties of 0.3 μm thick (Ca + Co)P coatings on a Ti substrate can be tailored by employing (Ca + Co)P targets with different microstructures, and also by varying the temperature of the Ti substrate during deposition experiments.
T2  - Surface and Coatings Technology
T2  - Surface and Coatings TechnologySurface and Coatings Technology
T1  - Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium
SP  - 128275
VL  - 437
DO  - 10.1016/j.surfcoat.2022.128275
UR  - https://hdl.handle.net/21.15107/rcub_dais_12953
ER  - 

@article{
author = "Marković, Smilja and Rau, Julietta V. and De Bonis, Angela and De Bellis, Giovanni and Stojanović, Zoran and Veselinović, Ljiljana and Mitrić, Miodrag and Ignjatović, Nenad and Škapin, Srečo Davor and Vengust, Damjan",
year = "2022",
abstract = "Dense calcium phosphate-based ceramics were fabricated to be used as targets for pulsed laser deposition (PLD). Nanostructured cobalt-substituted hydroxyapatite (Co:HAP) was used as a starting powder. To vary phase composition and microstructure of targets, two sintering approaches were applied, conventional (CS) and two-step sintering (TSS). The obtained results show that in both cases biphasic calcium phosphate (BCP) ceramics (targets) were prepared, with slightly different HAP-to-β–TCP amount ratio and a significantly different microstructure. While the CS method yielded fully dense ceramics with an average grain size of 1.3 μm, the ceramics prepared by TSS had a density of 98.5%, with a predominant grain size below 100 nm. (Ca + Co)P coatings were prepared by PLD of (Ca + Co)P targets. The temperature of the Ti substrate was adjusted to be 25 and 500 °C. The results show that the phase composition of (Ca + Co)P coatings depended on the phase composition of targets as well as on the temperature of the Ti substrate. The coating prepared at 25 °C using CS target consisted of three calcium phosphate phases, HAP, β–TCP and α–TCP; when the TSS target was used, the coating was biphasic, containing HAP and β–TCP. When the substrate was heated to 500 °C, regardless of whether the CS or the TSS target was used, the deposited coatings were composed of HAP and α–TCP. Due to different phase compositions, the (Ca + Co)P coatings deposited at 25 °C showed an improved hardness compared to those deposited at 500 °C. The obtained results confirmed that the phase composition, morphology and mechanical properties of 0.3 μm thick (Ca + Co)P coatings on a Ti substrate can be tailored by employing (Ca + Co)P targets with different microstructures, and also by varying the temperature of the Ti substrate during deposition experiments.",
journal = "Surface and Coatings Technology, Surface and Coatings TechnologySurface and Coatings Technology",
title = "Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium",
pages = "128275",
volume = "437",
doi = "10.1016/j.surfcoat.2022.128275",
url = "https://hdl.handle.net/21.15107/rcub_dais_12953"
}

Marković, S., Rau, J. V., De Bonis, A., De Bellis, G., Stojanović, Z., Veselinović, L., Mitrić, M., Ignjatović, N., Škapin, S. D.,& Vengust, D.. (2022). Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium. in Surface and Coatings Technology, 437, 128275.
https://doi.org/10.1016/j.surfcoat.2022.128275
https://hdl.handle.net/21.15107/rcub_dais_12953

Marković S, Rau JV, De Bonis A, De Bellis G, Stojanović Z, Veselinović L, Mitrić M, Ignjatović N, Škapin SD, Vengust D. Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium. in Surface and Coatings Technology. 2022;437:128275.
doi:10.1016/j.surfcoat.2022.128275
https://hdl.handle.net/21.15107/rcub_dais_12953 .

Marković, Smilja, Rau, Julietta V., De Bonis, Angela, De Bellis, Giovanni, Stojanović, Zoran, Veselinović, Ljiljana, Mitrić, Miodrag, Ignjatović, Nenad, Škapin, Srečo Davor, Vengust, Damjan, "Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium" in Surface and Coatings Technology, 437 (2022):128275,
https://doi.org/10.1016/j.surfcoat.2022.128275 .,
https://hdl.handle.net/21.15107/rcub_dais_12953 .

TY  - JOUR
AU  - Marković, Smilja
AU  - Rau, Julietta V.
AU  - De Bonis, Angela
AU  - De Bellis, Giovanni
AU  - Stojanović, Zoran
AU  - Veselinović, Ljiljana
AU  - Mitrić, Miodrag
AU  - Ignjatović, Nenad
AU  - Škapin, Srečo Davor
AU  - Vengust, Damjan
PY  - 2022
UR  - https://dais.sanu.ac.rs/123456789/13034
AB  - Dense calcium phosphate-based ceramics were fabricated to be used as targets for pulsed laser deposition (PLD). Nanostructured cobalt-substituted hydroxyapatite (Co:HAP) was used as a starting powder. To vary phase composition and microstructure of targets, two sintering approaches were applied, conventional (CS) and two-step sintering (TSS). The obtained results show that in both cases biphasic calcium phosphate (BCP) ceramics (targets) were prepared, with slightly different HAP-to-β–TCP amount ratio and a significantly different microstructure. While the CS method yielded fully dense ceramics with an average grain size of 1.3 μm, the ceramics prepared by TSS had a density of 98.5%, with a predominant grain size below 100 nm. (Ca + Co)P coatings were prepared by PLD of (Ca + Co)P targets. The temperature of the Ti substrate was adjusted to be 25 and 500 °C. The results show that the phase composition of (Ca + Co)P coatings depended on the phase composition of targets as well as on the temperature of the Ti substrate. The coating prepared at 25 °C using CS target consisted of three calcium phosphate phases, HAP, β–TCP and α–TCP; when the TSS target was used, the coating was biphasic, containing HAP and β–TCP. When the substrate was heated to 500 °C, regardless of whether the CS or the TSS target was used, the deposited coatings were composed of HAP and α–TCP. Due to different phase compositions, the (Ca + Co)P coatings deposited at 25 °C showed an improved hardness compared to those deposited at 500 °C. The obtained results confirmed that the phase composition, morphology and mechanical properties of 0.3 μm thick (Ca + Co)P coatings on a Ti substrate can be tailored by employing (Ca + Co)P targets with different microstructures, and also by varying the temperature of the Ti substrate during deposition experiments.
T2  - Surface and Coatings Technology
T1  - Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium
SP  - 128275
VL  - 437
DO  - 10.1016/j.surfcoat.2022.128275
UR  - https://hdl.handle.net/21.15107/rcub_dais_13034
ER  - 

@article{
author = "Marković, Smilja and Rau, Julietta V. and De Bonis, Angela and De Bellis, Giovanni and Stojanović, Zoran and Veselinović, Ljiljana and Mitrić, Miodrag and Ignjatović, Nenad and Škapin, Srečo Davor and Vengust, Damjan",
year = "2022",
abstract = "Dense calcium phosphate-based ceramics were fabricated to be used as targets for pulsed laser deposition (PLD). Nanostructured cobalt-substituted hydroxyapatite (Co:HAP) was used as a starting powder. To vary phase composition and microstructure of targets, two sintering approaches were applied, conventional (CS) and two-step sintering (TSS). The obtained results show that in both cases biphasic calcium phosphate (BCP) ceramics (targets) were prepared, with slightly different HAP-to-β–TCP amount ratio and a significantly different microstructure. While the CS method yielded fully dense ceramics with an average grain size of 1.3 μm, the ceramics prepared by TSS had a density of 98.5%, with a predominant grain size below 100 nm. (Ca + Co)P coatings were prepared by PLD of (Ca + Co)P targets. The temperature of the Ti substrate was adjusted to be 25 and 500 °C. The results show that the phase composition of (Ca + Co)P coatings depended on the phase composition of targets as well as on the temperature of the Ti substrate. The coating prepared at 25 °C using CS target consisted of three calcium phosphate phases, HAP, β–TCP and α–TCP; when the TSS target was used, the coating was biphasic, containing HAP and β–TCP. When the substrate was heated to 500 °C, regardless of whether the CS or the TSS target was used, the deposited coatings were composed of HAP and α–TCP. Due to different phase compositions, the (Ca + Co)P coatings deposited at 25 °C showed an improved hardness compared to those deposited at 500 °C. The obtained results confirmed that the phase composition, morphology and mechanical properties of 0.3 μm thick (Ca + Co)P coatings on a Ti substrate can be tailored by employing (Ca + Co)P targets with different microstructures, and also by varying the temperature of the Ti substrate during deposition experiments.",
journal = "Surface and Coatings Technology",
title = "Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium",
pages = "128275",
volume = "437",
doi = "10.1016/j.surfcoat.2022.128275",
url = "https://hdl.handle.net/21.15107/rcub_dais_13034"
}

Marković, S., Rau, J. V., De Bonis, A., De Bellis, G., Stojanović, Z., Veselinović, L., Mitrić, M., Ignjatović, N., Škapin, S. D.,& Vengust, D.. (2022). Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium. in Surface and Coatings Technology, 437, 128275.
https://doi.org/10.1016/j.surfcoat.2022.128275
https://hdl.handle.net/21.15107/rcub_dais_13034

Marković S, Rau JV, De Bonis A, De Bellis G, Stojanović Z, Veselinović L, Mitrić M, Ignjatović N, Škapin SD, Vengust D. Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium. in Surface and Coatings Technology. 2022;437:128275.
doi:10.1016/j.surfcoat.2022.128275
https://hdl.handle.net/21.15107/rcub_dais_13034 .

Marković, Smilja, Rau, Julietta V., De Bonis, Angela, De Bellis, Giovanni, Stojanović, Zoran, Veselinović, Ljiljana, Mitrić, Miodrag, Ignjatović, Nenad, Škapin, Srečo Davor, Vengust, Damjan, "Pathway to tailor the phase composition, microstructure and mechanical properties of pulsed laser deposited cobalt-substituted calcium phosphate coatings on titanium" in Surface and Coatings Technology, 437 (2022):128275,
https://doi.org/10.1016/j.surfcoat.2022.128275 .,
https://hdl.handle.net/21.15107/rcub_dais_13034 .

TY  - CONF
AU  - Guševac Stojanović, Ivana
AU  - Tatalović, N.
AU  - Veljković, F.
AU  - Martinović, J.
AU  - Zarić Kontić, M.
AU  - Blagojević, D.
AU  - Stojanović, Zoran
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://www.ecnp.eu/congress2022/ECNPcongress/programme/programme#!abstractdetails/0000506150
UR  - https://dais.sanu.ac.rs/123456789/13626
AB  - Introduction: Cerebral hypoperfusion (CH), a reduced cerebral blood flow, characteristic for aging and neurodegenerative disorders, might be associated with a pro-oxidative state in the brain due to the generation of reactive oxygen species (ROS) that cause neuronal damage. These overgenerated pro-oxidants might be reduced, disabled and neutralized by the endogenous antioxidant enzymes, including superoxide dismutase (SOD) and catalase (CAT). A sex steroid hormone, progesterone, in several experimental models of neuronal injury exerts anti-oxidative properties upregulating anti-oxidative molecules and thus promoting neuroprotection. However, its efficacy in the state of CH is still unknown and it is necessary to better understand the mechanism underlying this hormone’s neuroprotective effects.
Aim: We investigated whether progesterone is able to modulate CH-induced pro-oxidative/anti-oxidative imbalance, as well as SOD and CAT activities, in the prefrontal cortex of three-month-old male Wistar rats subjected to permanent bilateral common carotid artery occlusion (2VO).
Methods: The appropriate actions were undertaken to reduce the distress of the animals in agreement with the European Community Council Directive of 86/609/EEC and 010/63/EU for animal experiments. All experimental procedures were allowed by the Ethical Committee for the Use of Laboratory Animals of VINČA Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia (protocol authorization numbers 02/11 and 323-07-04253/2016-05). Following chloral hydrate anaesthesia, 8 rats randomly assigned in 2VO groups were double occluded with 5–0 silk suture, while 4 animals from sham operated group were subjected to the same surgical procedure but without actual ligation of carotid arteries. Four hours following the surgical procedure animals from sham operated group, used as controls, were subcutaneously treated with vehicle (commercial flax oil, 1 mg/kg/day, S + V), while animals in 2VO groups were subjected to either progesterone (1.7 mg/kg/day, 2VO + P) or vehicle (commercial flax oil, 1 mg/kg/day, 2VO + V). Following 7 days lasting treatments, pro-oxidative/anti-oxidative balance was assessed according to the method of Alamdari et al. [1]; while activities of anti-oxidative enzymes were determined as described in the study by Tatalović et al. [2]. One-way analysis of variance (ANOVA) test followed by Tukey’s post hoc test was employed to analyse data. The values of p < 0.05 or less were considered statistically significant.
Results: Obtained results demonstrate that compared to controls, 2VO and vehicle treatment induced a significant increase of pro-oxidants levels (p < 0.01) as well as the activities of both investigated anti-oxidative enzymes, although only the CAT activity was significantly increased (p < 0.05). Following progesterone treatment, pro-oxidants levels were lowered to the control level which caused the difference between the 2VO groups (p < 0.05). In parallel, no statistically significant change in SOD activity was observed, while CAT was upregulated (p < 0.05).
Conclusion: Presented results suggest that in the prefrontal cortex in the state of CH, progesterone, by modulating the CAT activity, downregulates overgenerated reactive species, reduces CH-induced oxidative stress and exerts anti-oxidative outcomes.
PB  - ECNP
C3  - 35the ECNP Congress, 15-18 October 2022, Vienna, Austria
T1  - Progesterone exerts protective effects in rat permanent bilateral common carotid artery occlusion model
SP  - P.0477
UR  - https://hdl.handle.net/21.15107/rcub_dais_13626
ER  - 

@conference{
author = "Guševac Stojanović, Ivana and Tatalović, N. and Veljković, F. and Martinović, J. and Zarić Kontić, M. and Blagojević, D. and Stojanović, Zoran and Drakulić, Dunja",
year = "2022",
abstract = "Introduction: Cerebral hypoperfusion (CH), a reduced cerebral blood flow, characteristic for aging and neurodegenerative disorders, might be associated with a pro-oxidative state in the brain due to the generation of reactive oxygen species (ROS) that cause neuronal damage. These overgenerated pro-oxidants might be reduced, disabled and neutralized by the endogenous antioxidant enzymes, including superoxide dismutase (SOD) and catalase (CAT). A sex steroid hormone, progesterone, in several experimental models of neuronal injury exerts anti-oxidative properties upregulating anti-oxidative molecules and thus promoting neuroprotection. However, its efficacy in the state of CH is still unknown and it is necessary to better understand the mechanism underlying this hormone’s neuroprotective effects.
Aim: We investigated whether progesterone is able to modulate CH-induced pro-oxidative/anti-oxidative imbalance, as well as SOD and CAT activities, in the prefrontal cortex of three-month-old male Wistar rats subjected to permanent bilateral common carotid artery occlusion (2VO).
Methods: The appropriate actions were undertaken to reduce the distress of the animals in agreement with the European Community Council Directive of 86/609/EEC and 010/63/EU for animal experiments. All experimental procedures were allowed by the Ethical Committee for the Use of Laboratory Animals of VINČA Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia (protocol authorization numbers 02/11 and 323-07-04253/2016-05). Following chloral hydrate anaesthesia, 8 rats randomly assigned in 2VO groups were double occluded with 5–0 silk suture, while 4 animals from sham operated group were subjected to the same surgical procedure but without actual ligation of carotid arteries. Four hours following the surgical procedure animals from sham operated group, used as controls, were subcutaneously treated with vehicle (commercial flax oil, 1 mg/kg/day, S + V), while animals in 2VO groups were subjected to either progesterone (1.7 mg/kg/day, 2VO + P) or vehicle (commercial flax oil, 1 mg/kg/day, 2VO + V). Following 7 days lasting treatments, pro-oxidative/anti-oxidative balance was assessed according to the method of Alamdari et al. [1]; while activities of anti-oxidative enzymes were determined as described in the study by Tatalović et al. [2]. One-way analysis of variance (ANOVA) test followed by Tukey’s post hoc test was employed to analyse data. The values of p < 0.05 or less were considered statistically significant.
Results: Obtained results demonstrate that compared to controls, 2VO and vehicle treatment induced a significant increase of pro-oxidants levels (p < 0.01) as well as the activities of both investigated anti-oxidative enzymes, although only the CAT activity was significantly increased (p < 0.05). Following progesterone treatment, pro-oxidants levels were lowered to the control level which caused the difference between the 2VO groups (p < 0.05). In parallel, no statistically significant change in SOD activity was observed, while CAT was upregulated (p < 0.05).
Conclusion: Presented results suggest that in the prefrontal cortex in the state of CH, progesterone, by modulating the CAT activity, downregulates overgenerated reactive species, reduces CH-induced oxidative stress and exerts anti-oxidative outcomes.",
publisher = "ECNP",
journal = "35the ECNP Congress, 15-18 October 2022, Vienna, Austria",
title = "Progesterone exerts protective effects in rat permanent bilateral common carotid artery occlusion model",
pages = "P.0477",
url = "https://hdl.handle.net/21.15107/rcub_dais_13626"
}

Guševac Stojanović, I., Tatalović, N., Veljković, F., Martinović, J., Zarić Kontić, M., Blagojević, D., Stojanović, Z.,& Drakulić, D.. (2022). Progesterone exerts protective effects in rat permanent bilateral common carotid artery occlusion model. in 35the ECNP Congress, 15-18 October 2022, Vienna, Austria
ECNP., P.0477.
https://hdl.handle.net/21.15107/rcub_dais_13626

Guševac Stojanović I, Tatalović N, Veljković F, Martinović J, Zarić Kontić M, Blagojević D, Stojanović Z, Drakulić D. Progesterone exerts protective effects in rat permanent bilateral common carotid artery occlusion model. in 35the ECNP Congress, 15-18 October 2022, Vienna, Austria. 2022;:P.0477.
https://hdl.handle.net/21.15107/rcub_dais_13626 .

Guševac Stojanović, Ivana, Tatalović, N., Veljković, F., Martinović, J., Zarić Kontić, M., Blagojević, D., Stojanović, Zoran, Drakulić, Dunja, "Progesterone exerts protective effects in rat permanent bilateral common carotid artery occlusion model" in 35the ECNP Congress, 15-18 October 2022, Vienna, Austria (2022):P.0477,
https://hdl.handle.net/21.15107/rcub_dais_13626 .

TY  - CONF
AU  - Stojanović, Zoran
AU  - Drakulić, Dunja
AU  - Veljković, F.
AU  - Martinović, J.
AU  - Todorović, A.
AU  - Filipović, Nenad
AU  - Stevanović, Magdalena
AU  - Guševac Stojanović, Ivana
PY  - 2022
UR  - https://www.ecnp.eu/congress2022/ECNPcongress/programme/programme#!abstractdetails/0000505040
UR  - https://dais.sanu.ac.rs/123456789/13625
AB  - Introduction: As a result of human activity, the amount of plastic waste has increased immensely in the environment. While the main concern has been orientated toward visible litter, more recently fragments of plastic less than 5 mm in diameter, called microplastic particles (MP), raised the attention due to their ability to induce toxic effects in organisms. The toxicity of MP increases with a decrease in size since smaller sized particles are absorbed systematically and accumulated in different organs/tissues, including brain.

Aim: Present study is designed to compare possible toxic acute effects of different sized MP, originating from polyethylene-terephthalate bottles, on toxicity signs, sensory-motor functions and relative brain weight in young male Wistar rats.

Methods: Rats (n = 24) were divided in four experimental groups: (I) intact (controls); Q that orally received a 2.5 ml of Milli-Q; P1/P2 that were respectively orally administrated with 35 mg/kg of MP in median diameter of either 40 or 70 μm dissolved in a 2.5 ml of Milli-Q. 24 h after treatments, using toxicity clinical test, we assessed the agitation, convulsion, piloerection, sleepiness and lethargy. Parameters were valued as: – (no effect), + (mild effect), ++ (moderate effect) and +++ (major effect). Then, we evaluated sensory-motor functions by monitoring: consciousness (scored 0/1 point), respiration (scored 0/1), spontaneous activity (scored 0/1/2/3), forepaw outstretching (scored 0/1/2), climbing (scored 0/1), visual placing (scored 0/1), cage grasp (scored 0/1), gait posture (scored 0/1/2), geotaxis (scored 0/1), hearing (scored 0/1) and pacing/circling (scored 0/1). Total score was expressed as the sum of average scores of all investigated parameters and graded on the scale from 0 to 15. Then, rats were weighed and sacrificed, while their brains were carefully removed and weighed. The relative brain weights were calculated as the ratio of brain (wet tissue, mg) weight to body weight (g). For toxicity clinical testing a descriptive analysis was used while other data were analysed by One-way analysis of variance followed by Tukey’s posthoc test. Results were considered significant at p < 0.05.
Results: Clinical toxicity signs were similar between groups while results of sensory-motor test point to unaltered sensory-motor functions upon MP treatments compared to controls (F (3, 20) = 0.9538; P = 0.4336). The absence of changes might be attributed to acute treatment, brief evaluation period and lack of cumulative effect upon MP treatments. Nonetheless, only smaller sized MP led to an increase in relative brain weight compared to controls (F (3, 20) = 3.425; P = 0.0369; p < 0.05) which might indicate the capability of smaller sized MP to cross blood-brain barrier and be accumulated in the brain inducing oxidative stress and inflammatory response. Although larger sized MP did not cause changes in relative brain weight, the possible modulations of additional parameters that were not the focus of this study should not be omitted.
Conclusion: According to the presented results, even a smaller sized MP applied in a single dose could be harmful to health, thus, greater control of plastic usage and disposal is essential for humanity.
PB  - ECNP
C3  - 35the ECNP Congress, 15-18 October 2022, Vienna, Austria
T1  - Effects of single orally administrated different sized microplastic particles – acute toxicity study in adult male rats
SP  - P.0244
UR  - https://hdl.handle.net/21.15107/rcub_dais_13625
ER  - 

@conference{
author = "Stojanović, Zoran and Drakulić, Dunja and Veljković, F. and Martinović, J. and Todorović, A. and Filipović, Nenad and Stevanović, Magdalena and Guševac Stojanović, Ivana",
year = "2022",
abstract = "Introduction: As a result of human activity, the amount of plastic waste has increased immensely in the environment. While the main concern has been orientated toward visible litter, more recently fragments of plastic less than 5 mm in diameter, called microplastic particles (MP), raised the attention due to their ability to induce toxic effects in organisms. The toxicity of MP increases with a decrease in size since smaller sized particles are absorbed systematically and accumulated in different organs/tissues, including brain.

Aim: Present study is designed to compare possible toxic acute effects of different sized MP, originating from polyethylene-terephthalate bottles, on toxicity signs, sensory-motor functions and relative brain weight in young male Wistar rats.

Methods: Rats (n = 24) were divided in four experimental groups: (I) intact (controls); Q that orally received a 2.5 ml of Milli-Q; P1/P2 that were respectively orally administrated with 35 mg/kg of MP in median diameter of either 40 or 70 μm dissolved in a 2.5 ml of Milli-Q. 24 h after treatments, using toxicity clinical test, we assessed the agitation, convulsion, piloerection, sleepiness and lethargy. Parameters were valued as: – (no effect), + (mild effect), ++ (moderate effect) and +++ (major effect). Then, we evaluated sensory-motor functions by monitoring: consciousness (scored 0/1 point), respiration (scored 0/1), spontaneous activity (scored 0/1/2/3), forepaw outstretching (scored 0/1/2), climbing (scored 0/1), visual placing (scored 0/1), cage grasp (scored 0/1), gait posture (scored 0/1/2), geotaxis (scored 0/1), hearing (scored 0/1) and pacing/circling (scored 0/1). Total score was expressed as the sum of average scores of all investigated parameters and graded on the scale from 0 to 15. Then, rats were weighed and sacrificed, while their brains were carefully removed and weighed. The relative brain weights were calculated as the ratio of brain (wet tissue, mg) weight to body weight (g). For toxicity clinical testing a descriptive analysis was used while other data were analysed by One-way analysis of variance followed by Tukey’s posthoc test. Results were considered significant at p < 0.05.
Results: Clinical toxicity signs were similar between groups while results of sensory-motor test point to unaltered sensory-motor functions upon MP treatments compared to controls (F (3, 20) = 0.9538; P = 0.4336). The absence of changes might be attributed to acute treatment, brief evaluation period and lack of cumulative effect upon MP treatments. Nonetheless, only smaller sized MP led to an increase in relative brain weight compared to controls (F (3, 20) = 3.425; P = 0.0369; p < 0.05) which might indicate the capability of smaller sized MP to cross blood-brain barrier and be accumulated in the brain inducing oxidative stress and inflammatory response. Although larger sized MP did not cause changes in relative brain weight, the possible modulations of additional parameters that were not the focus of this study should not be omitted.
Conclusion: According to the presented results, even a smaller sized MP applied in a single dose could be harmful to health, thus, greater control of plastic usage and disposal is essential for humanity.",
publisher = "ECNP",
journal = "35the ECNP Congress, 15-18 October 2022, Vienna, Austria",
title = "Effects of single orally administrated different sized microplastic particles – acute toxicity study in adult male rats",
pages = "P.0244",
url = "https://hdl.handle.net/21.15107/rcub_dais_13625"
}

Stojanović, Z., Drakulić, D., Veljković, F., Martinović, J., Todorović, A., Filipović, N., Stevanović, M.,& Guševac Stojanović, I.. (2022). Effects of single orally administrated different sized microplastic particles – acute toxicity study in adult male rats. in 35the ECNP Congress, 15-18 October 2022, Vienna, Austria
ECNP., P.0244.
https://hdl.handle.net/21.15107/rcub_dais_13625

Stojanović Z, Drakulić D, Veljković F, Martinović J, Todorović A, Filipović N, Stevanović M, Guševac Stojanović I. Effects of single orally administrated different sized microplastic particles – acute toxicity study in adult male rats. in 35the ECNP Congress, 15-18 October 2022, Vienna, Austria. 2022;:P.0244.
https://hdl.handle.net/21.15107/rcub_dais_13625 .

Stojanović, Zoran, Drakulić, Dunja, Veljković, F., Martinović, J., Todorović, A., Filipović, Nenad, Stevanović, Magdalena, Guševac Stojanović, Ivana, "Effects of single orally administrated different sized microplastic particles – acute toxicity study in adult male rats" in 35the ECNP Congress, 15-18 October 2022, Vienna, Austria (2022):P.0244,
https://hdl.handle.net/21.15107/rcub_dais_13625 .

TY  - CONF
AU  - Guševac Stojanović, Ivana
AU  - Martinović, J.
AU  - Zarić Kontić, M.
AU  - Mitrović, N.
AU  - Stojanović, Zoran
AU  - Grković, I.
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://dais.sanu.ac.rs/123456789/13624
AB  - In the brain, three isoforms of nitric oxide synthase (NOS) regulate production of nitric oxide (NO), a signalling molecule with a role in cerebral blood flow regulation. Depending on the stimulus, NO exerts dual nature, from neuroprotective to neurodestructive. Given the scarcity of literature data on the involvement of nitrosative stress indicators in the rat hippocampal response to 7-day lasting progesterone (P4) treatment following permanent occlusion of both common carotid arteries, we assessed NO level and protein expressions of endothelial nitric oxide synthase (eNOS, including its total (t-eNOS) and phosphorylated at Ser1177 isoform (p-eNOS Ser1177)). According to obtained results, elevated NO levels occurred due to activity of other NOS forms since eNOS expressions were similar between experimental groups. Although NO level was downscaled it was still elevated in occluded animals treated with P4, showing modest anti-nitrosative effect of this potent steroid in the hippocampus.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022
T1  - Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion
SP  - 79
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_dais_13624
ER  - 

@conference{
author = "Guševac Stojanović, Ivana and Martinović, J. and Zarić Kontić, M. and Mitrović, N. and Stojanović, Zoran and Grković, I. and Drakulić, Dunja",
year = "2022",
abstract = "In the brain, three isoforms of nitric oxide synthase (NOS) regulate production of nitric oxide (NO), a signalling molecule with a role in cerebral blood flow regulation. Depending on the stimulus, NO exerts dual nature, from neuroprotective to neurodestructive. Given the scarcity of literature data on the involvement of nitrosative stress indicators in the rat hippocampal response to 7-day lasting progesterone (P4) treatment following permanent occlusion of both common carotid arteries, we assessed NO level and protein expressions of endothelial nitric oxide synthase (eNOS, including its total (t-eNOS) and phosphorylated at Ser1177 isoform (p-eNOS Ser1177)). According to obtained results, elevated NO levels occurred due to activity of other NOS forms since eNOS expressions were similar between experimental groups. Although NO level was downscaled it was still elevated in occluded animals treated with P4, showing modest anti-nitrosative effect of this potent steroid in the hippocampus.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022",
title = "Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion",
pages = "79-79",
url = "https://hdl.handle.net/21.15107/rcub_dais_13624"
}

Guševac Stojanović, I., Martinović, J., Zarić Kontić, M., Mitrović, N., Stojanović, Z., Grković, I.,& Drakulić, D.. (2022). Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion. in Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022
Belgrade : Society of Physical Chemists of Serbia., 79-79.
https://hdl.handle.net/21.15107/rcub_dais_13624

Guševac Stojanović I, Martinović J, Zarić Kontić M, Mitrović N, Stojanović Z, Grković I, Drakulić D. Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion. in Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022. 2022;:79-79.
https://hdl.handle.net/21.15107/rcub_dais_13624 .

Guševac Stojanović, Ivana, Martinović, J., Zarić Kontić, M., Mitrović, N., Stojanović, Zoran, Grković, I., Drakulić, Dunja, "Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion" in Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022 (2022):79-79,
https://hdl.handle.net/21.15107/rcub_dais_13624 .

TY  - JOUR
AU  - Pavić, Aleksandar
AU  - Stojanović, Zoran
AU  - Pekmezović, Marina
AU  - Veljović, Đorđe
AU  - O’Connor, Kevin
AU  - Malagurski, Ivana
AU  - Nikodinović-Runić, Jasmina
PY  - 2022
UR  - https://dais.sanu.ac.rs/123456789/12954
AB  - Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall reduced systemic drug toxicity. In this study, we encapsulated Nys and AmB in medium chain length polyhydroxyalkanoates (mcl-PHA) microspheres (7–8 µm in diameter). The obtained formulations have been validated for antifungal activity in vitro against a panel of pathogenic fungi including species of Candida, Aspergillus, Microsporum and Trichophyton genera and toxicity and efficacy in vivo using the zebrafish model of disseminated candidiasis. While free polyenes, especially AmB, were highly toxic to zebrafish embryos at the effective (MIC) doses, after their loading into mcl-PHA microspheres, inner organ toxicity and teratogenicity associated with both drugs were not observed, even at 100 × MIC doses. The obtained mcl-PHA/polyene formulations have successfully eradicated C. albicans infection and showed an improved therapeutic profile in zebrafish by enhancing infected embryos survival. This approach is contributing to the antifungal arsenal as polyenes, although the first broad-spectrum antifungals on the market are still the gold standard for treatment of fungal infections.
PB  - MDPI
T2  - Pharmaceutics
T1  - Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model
SP  - 696
VL  - 14
IS  - 4
DO  - 10.3390/pharmaceutics14040696
UR  - https://hdl.handle.net/21.15107/rcub_dais_12954
ER  - 

@article{
author = "Pavić, Aleksandar and Stojanović, Zoran and Pekmezović, Marina and Veljović, Đorđe and O’Connor, Kevin and Malagurski, Ivana and Nikodinović-Runić, Jasmina",
year = "2022",
abstract = "Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall reduced systemic drug toxicity. In this study, we encapsulated Nys and AmB in medium chain length polyhydroxyalkanoates (mcl-PHA) microspheres (7–8 µm in diameter). The obtained formulations have been validated for antifungal activity in vitro against a panel of pathogenic fungi including species of Candida, Aspergillus, Microsporum and Trichophyton genera and toxicity and efficacy in vivo using the zebrafish model of disseminated candidiasis. While free polyenes, especially AmB, were highly toxic to zebrafish embryos at the effective (MIC) doses, after their loading into mcl-PHA microspheres, inner organ toxicity and teratogenicity associated with both drugs were not observed, even at 100 × MIC doses. The obtained mcl-PHA/polyene formulations have successfully eradicated C. albicans infection and showed an improved therapeutic profile in zebrafish by enhancing infected embryos survival. This approach is contributing to the antifungal arsenal as polyenes, although the first broad-spectrum antifungals on the market are still the gold standard for treatment of fungal infections.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model",
pages = "696",
volume = "14",
number = "4",
doi = "10.3390/pharmaceutics14040696",
url = "https://hdl.handle.net/21.15107/rcub_dais_12954"
}

Pavić, A., Stojanović, Z., Pekmezović, M., Veljović, Đ., O’Connor, K., Malagurski, I.,& Nikodinović-Runić, J.. (2022). Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model. in Pharmaceutics
MDPI., 14(4), 696.
https://doi.org/10.3390/pharmaceutics14040696
https://hdl.handle.net/21.15107/rcub_dais_12954

Pavić A, Stojanović Z, Pekmezović M, Veljović Đ, O’Connor K, Malagurski I, Nikodinović-Runić J. Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model. in Pharmaceutics. 2022;14(4):696.
doi:10.3390/pharmaceutics14040696
https://hdl.handle.net/21.15107/rcub_dais_12954 .

Pavić, Aleksandar, Stojanović, Zoran, Pekmezović, Marina, Veljović, Đorđe, O’Connor, Kevin, Malagurski, Ivana, Nikodinović-Runić, Jasmina, "Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model" in Pharmaceutics, 14, no. 4 (2022):696,
https://doi.org/10.3390/pharmaceutics14040696 .,
https://hdl.handle.net/21.15107/rcub_dais_12954 .

TY  - CONF
AU  - Stojanović, Zoran
AU  - Stevanović, Magdalena
PY  - 2022
UR  - https://dais.sanu.ac.rs/123456789/13614
AB  - In the past decade, scientists have made an outstanding progress in machine learning techniques, based on natural language processing, that takes advantage of vast number of material science documents to gain novel aspects on materials synthesis. Herein, we are comparing hydrothermal synthesis recipes for obtaining metal oxide nanomaterials carried out in our laboratory with learned synthesis recipes in terms of precursors, processing parameters, steps and product characteristics. As a starting point, open source tools and pre-trained models are used to get optimal hydrothermal synthesis recepies for desired material. This new approach is showing a great potential to become a standard method in planning viable synthesis routes for new materials.
PB  - Belgrade : Serbian Ceramic Society
C3  - Program and the Book of abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application X New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 26-27. September 2022.
T1  - From classical to machine learning aided approach - hydrothermal synthesis planning for metal oxide nanomaterials
SP  - 51
EP  - 51
UR  - https://hdl.handle.net/21.15107/rcub_dais_13614
ER  - 

@conference{
author = "Stojanović, Zoran and Stevanović, Magdalena",
year = "2022",
abstract = "In the past decade, scientists have made an outstanding progress in machine learning techniques, based on natural language processing, that takes advantage of vast number of material science documents to gain novel aspects on materials synthesis. Herein, we are comparing hydrothermal synthesis recipes for obtaining metal oxide nanomaterials carried out in our laboratory with learned synthesis recipes in terms of precursors, processing parameters, steps and product characteristics. As a starting point, open source tools and pre-trained models are used to get optimal hydrothermal synthesis recepies for desired material. This new approach is showing a great potential to become a standard method in planning viable synthesis routes for new materials.",
publisher = "Belgrade : Serbian Ceramic Society",
journal = "Program and the Book of abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application X New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 26-27. September 2022.",
title = "From classical to machine learning aided approach - hydrothermal synthesis planning for metal oxide nanomaterials",
pages = "51-51",
url = "https://hdl.handle.net/21.15107/rcub_dais_13614"
}

Stojanović, Z.,& Stevanović, M.. (2022). From classical to machine learning aided approach - hydrothermal synthesis planning for metal oxide nanomaterials. in Program and the Book of abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application X New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 26-27. September 2022.
Belgrade : Serbian Ceramic Society., 51-51.
https://hdl.handle.net/21.15107/rcub_dais_13614

Stojanović Z, Stevanović M. From classical to machine learning aided approach - hydrothermal synthesis planning for metal oxide nanomaterials. in Program and the Book of abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application X New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 26-27. September 2022.. 2022;:51-51.
https://hdl.handle.net/21.15107/rcub_dais_13614 .

Stojanović, Zoran, Stevanović, Magdalena, "From classical to machine learning aided approach - hydrothermal synthesis planning for metal oxide nanomaterials" in Program and the Book of abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application X New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 26-27. September 2022. (2022):51-51,
https://hdl.handle.net/21.15107/rcub_dais_13614 .

TY  - CONF
AU  - Guševac Stojanović, I.
AU  - Drakulić, Dunja
AU  - Todorović, A.
AU  - Filipović, Nenad
AU  - Stojanović, Zoran
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/12359
AB  - Worldwide pollution with plastic debris represents tremendous environmental issue. Small particles originated from plastic bottles exert various effects in organisms when exposed chronically, while the effects of a single exposure are completely unknown. Thus, to test their potential health impact, male Wistar rats were exposed by oral gavage to a single dose of microplastic particles (MP) derived from polyethylene terephthalate (PET) bottles (1.4, 35 or 125 mg/kg with median diameter of 85 μm). Food and water intakes were monitored, and neurological and clinical tests were conducted. Obtained results point to lower food and water intakes in groups that received two higher MP doses indicating to interference with normal digestion. None of three used MP doses provoked neurological and clinical impairments either due to short-term exposure and/or lack of MP cumulative effect. Overall, presented results indicate that exposure to a single dose of MP can initiate health issues.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical chemistry 2021
T1  - Does exposure to a single dose of microplastic represent a health risk?
SP  - 102
EP  - 102
UR  - https://hdl.handle.net/21.15107/rcub_dais_12359
ER  - 

@conference{
author = "Guševac Stojanović, I. and Drakulić, Dunja and Todorović, A. and Filipović, Nenad and Stojanović, Zoran",
year = "2021",
abstract = "Worldwide pollution with plastic debris represents tremendous environmental issue. Small particles originated from plastic bottles exert various effects in organisms when exposed chronically, while the effects of a single exposure are completely unknown. Thus, to test their potential health impact, male Wistar rats were exposed by oral gavage to a single dose of microplastic particles (MP) derived from polyethylene terephthalate (PET) bottles (1.4, 35 or 125 mg/kg with median diameter of 85 μm). Food and water intakes were monitored, and neurological and clinical tests were conducted. Obtained results point to lower food and water intakes in groups that received two higher MP doses indicating to interference with normal digestion. None of three used MP doses provoked neurological and clinical impairments either due to short-term exposure and/or lack of MP cumulative effect. Overall, presented results indicate that exposure to a single dose of MP can initiate health issues.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical chemistry 2021",
title = "Does exposure to a single dose of microplastic represent a health risk?",
pages = "102-102",
url = "https://hdl.handle.net/21.15107/rcub_dais_12359"
}

Guševac Stojanović, I., Drakulić, D., Todorović, A., Filipović, N.,& Stojanović, Z.. (2021). Does exposure to a single dose of microplastic represent a health risk?. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical chemistry 2021
Belgrade : Society of Physical Chemists of Serbia., 102-102.
https://hdl.handle.net/21.15107/rcub_dais_12359

Guševac Stojanović I, Drakulić D, Todorović A, Filipović N, Stojanović Z. Does exposure to a single dose of microplastic represent a health risk?. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical chemistry 2021. 2021;:102-102.
https://hdl.handle.net/21.15107/rcub_dais_12359 .

Guševac Stojanović, I., Drakulić, Dunja, Todorović, A., Filipović, Nenad, Stojanović, Zoran, "Does exposure to a single dose of microplastic represent a health risk?" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical chemistry 2021 (2021):102-102,
https://hdl.handle.net/21.15107/rcub_dais_12359 .

TY  - CONF
AU  - Todorović, A.
AU  - Pavlović, I.
AU  - Pejić, S.
AU  - Miletić Vukajlović, J.
AU  - Veljković, F.
AU  - Filipović Tričković, J.
AU  - Valenta Šobot, A.
AU  - Martinović, J.
AU  - Guševac Stojanović, I.
AU  - Stojanović, Zoran
AU  - Drakulić, Dunja
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/12379
AB  - Flaxseed oil, extracted from ripened flaxseeds, is functional food source that is associated with health benefits in many diseases, including cardiovascular,
cancer, osteoporosis, etc. Besides saturated fatty acids and monounsaturated fatty acids, it also contains easily oxidized polyunsaturated fatty acids of the n-3 family. In current study, we tested the effects of commercial flaxseed oil in rat liver by measuring parameters related to free radical challenge (pro/antioxidant balance (PAB), lipid peroxidation (LPO) products and glutathione (GSH) level). Overall, applied treatment maintains general prooxidant load and antioxidant capacity since the level of PAB was unchanged. However, it exerts significant modulatory effect on particular redox parameters by increasing the amount of LPO products and consequently the susceptibility of tissue to free radical oxidative damage, which challenges the antioxidant defence system that
in return elevates GSH concentration.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
T1  - Modulation of redox parameters in rat liver induced by flaxseed oil
SP  - 180
EP  - 183
UR  - https://hdl.handle.net/21.15107/rcub_dais_12379
ER  - 

@conference{
author = "Todorović, A. and Pavlović, I. and Pejić, S. and Miletić Vukajlović, J. and Veljković, F. and Filipović Tričković, J. and Valenta Šobot, A. and Martinović, J. and Guševac Stojanović, I. and Stojanović, Zoran and Drakulić, Dunja",
year = "2021",
abstract = "Flaxseed oil, extracted from ripened flaxseeds, is functional food source that is associated with health benefits in many diseases, including cardiovascular,
cancer, osteoporosis, etc. Besides saturated fatty acids and monounsaturated fatty acids, it also contains easily oxidized polyunsaturated fatty acids of the n-3 family. In current study, we tested the effects of commercial flaxseed oil in rat liver by measuring parameters related to free radical challenge (pro/antioxidant balance (PAB), lipid peroxidation (LPO) products and glutathione (GSH) level). Overall, applied treatment maintains general prooxidant load and antioxidant capacity since the level of PAB was unchanged. However, it exerts significant modulatory effect on particular redox parameters by increasing the amount of LPO products and consequently the susceptibility of tissue to free radical oxidative damage, which challenges the antioxidant defence system that
in return elevates GSH concentration.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021",
title = "Modulation of redox parameters in rat liver induced by flaxseed oil",
pages = "180-183",
url = "https://hdl.handle.net/21.15107/rcub_dais_12379"
}

Todorović, A., Pavlović, I., Pejić, S., Miletić Vukajlović, J., Veljković, F., Filipović Tričković, J., Valenta Šobot, A., Martinović, J., Guševac Stojanović, I., Stojanović, Z.,& Drakulić, D.. (2021). Modulation of redox parameters in rat liver induced by flaxseed oil. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
Belgrade : Vinča Institute of Nuclear Sciences., 180-183.
https://hdl.handle.net/21.15107/rcub_dais_12379

Todorović A, Pavlović I, Pejić S, Miletić Vukajlović J, Veljković F, Filipović Tričković J, Valenta Šobot A, Martinović J, Guševac Stojanović I, Stojanović Z, Drakulić D. Modulation of redox parameters in rat liver induced by flaxseed oil. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021. 2021;:180-183.
https://hdl.handle.net/21.15107/rcub_dais_12379 .

Todorović, A., Pavlović, I., Pejić, S., Miletić Vukajlović, J., Veljković, F., Filipović Tričković, J., Valenta Šobot, A., Martinović, J., Guševac Stojanović, I., Stojanović, Zoran, Drakulić, Dunja, "Modulation of redox parameters in rat liver induced by flaxseed oil" in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 (2021):180-183,
https://hdl.handle.net/21.15107/rcub_dais_12379 .

TY  - CONF
AU  - Martinović, J.
AU  - Guševac Stojanović, I.
AU  - Zarić, M
AU  - Todorović, A.
AU  - Veljković, F.
AU  - Pejić, S.
AU  - Stojanović, Zoran
AU  - Mitrović, N.
AU  - Grković, I.
AU  - Drakulić, Dunja
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/12378
AB  - D-galactose (d-gal) is an important physiological nutrient. According to the
widely accepted aging metabolic theory d-gal at high levels can be converted
into aldose and hydroperoxide, resulting in the overproduction of reactive
oxygen species (ROS). Increased ROS levels may subsequently cause oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis which are hallmarks of natural senescence as well as various pathological conditions. We investigated the effects of chronic oral d-gal intake (200 mg/kg and 500 mg/kg for 6 weeks) on physiological, neurological and toxicity parameters in 3 months old male Wistar rats. The obtained results indicate that body weight, food intake, serum glucose, neurological and toxicity status remained unaffected while urine proteins were significantly increased in d-gal treated rats. Although there was no effect on the general health status of the animals, our findings suggest that chronic oral d-gal administration may lead to renal dysfunction.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
T1  - Effects of chronic oral D-galactose treatment on general health status in male Wistar rats
SP  - 115
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_dais_12378
ER  - 

@conference{
author = "Martinović, J. and Guševac Stojanović, I. and Zarić, M and Todorović, A. and Veljković, F. and Pejić, S. and Stojanović, Zoran and Mitrović, N. and Grković, I. and Drakulić, Dunja",
year = "2021",
abstract = "D-galactose (d-gal) is an important physiological nutrient. According to the
widely accepted aging metabolic theory d-gal at high levels can be converted
into aldose and hydroperoxide, resulting in the overproduction of reactive
oxygen species (ROS). Increased ROS levels may subsequently cause oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis which are hallmarks of natural senescence as well as various pathological conditions. We investigated the effects of chronic oral d-gal intake (200 mg/kg and 500 mg/kg for 6 weeks) on physiological, neurological and toxicity parameters in 3 months old male Wistar rats. The obtained results indicate that body weight, food intake, serum glucose, neurological and toxicity status remained unaffected while urine proteins were significantly increased in d-gal treated rats. Although there was no effect on the general health status of the animals, our findings suggest that chronic oral d-gal administration may lead to renal dysfunction.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021",
title = "Effects of chronic oral D-galactose treatment on general health status in male Wistar rats",
pages = "115-118",
url = "https://hdl.handle.net/21.15107/rcub_dais_12378"
}

Martinović, J., Guševac Stojanović, I., Zarić, M., Todorović, A., Veljković, F., Pejić, S., Stojanović, Z., Mitrović, N., Grković, I.,& Drakulić, D.. (2021). Effects of chronic oral D-galactose treatment on general health status in male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
Belgrade : Vinča Institute of Nuclear Sciences., 115-118.
https://hdl.handle.net/21.15107/rcub_dais_12378

Martinović J, Guševac Stojanović I, Zarić M, Todorović A, Veljković F, Pejić S, Stojanović Z, Mitrović N, Grković I, Drakulić D. Effects of chronic oral D-galactose treatment on general health status in male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021. 2021;:115-118.
https://hdl.handle.net/21.15107/rcub_dais_12378 .

Martinović, J., Guševac Stojanović, I., Zarić, M, Todorović, A., Veljković, F., Pejić, S., Stojanović, Zoran, Mitrović, N., Grković, I., Drakulić, Dunja, "Effects of chronic oral D-galactose treatment on general health status in male Wistar rats" in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 (2021):115-118,
https://hdl.handle.net/21.15107/rcub_dais_12378 .

TY  - CONF
AU  - Guševac Stojanović, I.
AU  - Drakulić, Dunja
AU  - Todorović, A.
AU  - Filipović, Nenad
AU  - Stojanović, Zoran
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/13619
AB  - Worldwide pollution with plastic debris represents tremendous environmental issue. Small particles originated from plastic bottles exert various effects in organisms when exposed chronically, while the effects of a single exposure are completely unknown. Thus, to test their potential health impact, male Wistar rats were exposed by oral gavage to a single dose of microplastic particles (MP) derived from polyethylene terephthalate (PET) bottles (1.4, 35 or 125 mg/kg with median diameter of 85 μm). Food and water intakes were monitored, and neurological and clinical tests were conducted. Obtained results point to lower food and water intakes in groups that received two higher MP doses indicating to interference with normal digestion. None of three used MP doses provoked neurological and clinical impairments either due to short-term exposure and/or lack of MP cumulative effect. Overall, presented results indicate that exposure to a single dose of MP can initiate health issues.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2021
T1  - Does exposure to a single dose of microplastic represent a health risk?
SP  - 572
EP  - 575
UR  - https://hdl.handle.net/21.15107/rcub_dais_13619
ER  - 

@conference{
author = "Guševac Stojanović, I. and Drakulić, Dunja and Todorović, A. and Filipović, Nenad and Stojanović, Zoran",
year = "2021",
abstract = "Worldwide pollution with plastic debris represents tremendous environmental issue. Small particles originated from plastic bottles exert various effects in organisms when exposed chronically, while the effects of a single exposure are completely unknown. Thus, to test their potential health impact, male Wistar rats were exposed by oral gavage to a single dose of microplastic particles (MP) derived from polyethylene terephthalate (PET) bottles (1.4, 35 or 125 mg/kg with median diameter of 85 μm). Food and water intakes were monitored, and neurological and clinical tests were conducted. Obtained results point to lower food and water intakes in groups that received two higher MP doses indicating to interference with normal digestion. None of three used MP doses provoked neurological and clinical impairments either due to short-term exposure and/or lack of MP cumulative effect. Overall, presented results indicate that exposure to a single dose of MP can initiate health issues.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2021",
title = "Does exposure to a single dose of microplastic represent a health risk?",
pages = "572-575",
url = "https://hdl.handle.net/21.15107/rcub_dais_13619"
}

Guševac Stojanović, I., Drakulić, D., Todorović, A., Filipović, N.,& Stojanović, Z.. (2021). Does exposure to a single dose of microplastic represent a health risk?. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2021
Belgrade : Society of Physical Chemists of Serbia., 572-575.
https://hdl.handle.net/21.15107/rcub_dais_13619

Guševac Stojanović I, Drakulić D, Todorović A, Filipović N, Stojanović Z. Does exposure to a single dose of microplastic represent a health risk?. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2021. 2021;:572-575.
https://hdl.handle.net/21.15107/rcub_dais_13619 .

Guševac Stojanović, I., Drakulić, Dunja, Todorović, A., Filipović, Nenad, Stojanović, Zoran, "Does exposure to a single dose of microplastic represent a health risk?" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2021 (2021):572-575,
https://hdl.handle.net/21.15107/rcub_dais_13619 .

TY  - CONF
AU  - Stojanović, Zoran
AU  - Todorović, Ana
AU  - Martinović, Jelena
AU  - Filipović, Nenad
AU  - Veljković, Filip
AU  - Guševac Stojanović, Ivana
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/12381
AB  - Increased plastic usage creates environmental problems due to its accumulation and degradation into microplastic particles (MP), less than 5 mm in diameter. Particles from various sources like food and beverages contaminated with polyethylene terephthalate (PET) could accumulate in different tissues exerting adverse effects. Since data regarding potential acute toxicity in doses that represent realistic/daily ingested MP doses are entirely lacking, male Wistar rats were exposed to a single dose (1.4, 35 or 125 mg/kg) of PET-generated MP by oral gavage. Changes in wet organ weight to body weight ratio of testicles, adrenal glands and kidneys were examined 24 h following the treatment. Results point to increased organ/body weight ratio of testicles in rats exposed to two higher MP doses, while adrenal glands were augmented only after treatment with 125 mg/kg. Further research is needed to gain insight into the underlying mechanisms of the observed phenomenon.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
T1  - A single dose of microplastic particles induces changed in organ weight of male Wistar rats
SP  - 119
EP  - 122
UR  - https://hdl.handle.net/21.15107/rcub_dais_12381
ER  - 

@conference{
author = "Stojanović, Zoran and Todorović, Ana and Martinović, Jelena and Filipović, Nenad and Veljković, Filip and Guševac Stojanović, Ivana",
year = "2021",
abstract = "Increased plastic usage creates environmental problems due to its accumulation and degradation into microplastic particles (MP), less than 5 mm in diameter. Particles from various sources like food and beverages contaminated with polyethylene terephthalate (PET) could accumulate in different tissues exerting adverse effects. Since data regarding potential acute toxicity in doses that represent realistic/daily ingested MP doses are entirely lacking, male Wistar rats were exposed to a single dose (1.4, 35 or 125 mg/kg) of PET-generated MP by oral gavage. Changes in wet organ weight to body weight ratio of testicles, adrenal glands and kidneys were examined 24 h following the treatment. Results point to increased organ/body weight ratio of testicles in rats exposed to two higher MP doses, while adrenal glands were augmented only after treatment with 125 mg/kg. Further research is needed to gain insight into the underlying mechanisms of the observed phenomenon.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021",
title = "A single dose of microplastic particles induces changed in organ weight of male Wistar rats",
pages = "119-122",
url = "https://hdl.handle.net/21.15107/rcub_dais_12381"
}

Stojanović, Z., Todorović, A., Martinović, J., Filipović, N., Veljković, F.,& Guševac Stojanović, I.. (2021). A single dose of microplastic particles induces changed in organ weight of male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
Belgrade : Vinča Institute of Nuclear Sciences., 119-122.
https://hdl.handle.net/21.15107/rcub_dais_12381

Stojanović Z, Todorović A, Martinović J, Filipović N, Veljković F, Guševac Stojanović I. A single dose of microplastic particles induces changed in organ weight of male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021. 2021;:119-122.
https://hdl.handle.net/21.15107/rcub_dais_12381 .

Stojanović, Zoran, Todorović, Ana, Martinović, Jelena, Filipović, Nenad, Veljković, Filip, Guševac Stojanović, Ivana, "A single dose of microplastic particles induces changed in organ weight of male Wistar rats" in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 (2021):119-122,
https://hdl.handle.net/21.15107/rcub_dais_12381 .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Stojanović, Zoran
AU  - Stevanović, Magdalena
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/12358
AB  - Nanočestice selena (SeNPs) su specifična forma ovog elementa koja je u poslednje vreme postala predmet brojnih istraživanja, pogotovo u oblasti biomedicine. Do sada je razvijeno više metoda sinteze SeNPs, među kojima se najčešće koriste one koje podrazumevaju redukciju iz njegovih jedinjenja. U ovom radu ispitan je uticaj dva stabilizatora na morfologiju, veličinu i kristalno uređenje SeNPs dobijenih redukcijom natrijum selenita askorbinskom kiselinom. Kao stabilizatori SeNPs korišćeni su goveđi serum albumin (BSA) ili poliglutaminska kiselina (PGA). Na osnovu rezultata dobijenih metodama skenirajuće elektronske mikroskopije (FESEM), transmisione elektronske mikroskopije (TEM), energetske disperzione spektroskopije (EDS), elektronske difrakcije sa selektovane površine (SAED) i merenjem zeta potencijala, utvrđeno je da mehanizam stabilizacije tj. izbor stabilizatora može prouzrokovati različito kristalno uređenje unutar SeNPs. BSA se pokazao kao efikasniji stabilizator jer omogućuje dobijanje uniformnijih, manjih i amorfnih nanočestica selena.
AB  - Selenium nanoparticles (SeNPs) are specific form of this element that has recently become the subject of numerous research, especially in the field of biomedicine. Several synthesis procedures for obtaining SeNPs have been developed so far, among those including reduction of selenium salts are the most frequently used. In this work, it is examined the effect of two stabilizing agents on morphology, size, and crystallinity of obtained SeNPs. For this purpose, bovine serum albumin (BSA) and polyglutamic acid (PGA) were used as stabilizing agents while reduction of sodium selenite with ascorbic acid was elected as a synthesis procedure. Based on the results obtained from scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), selected area electron diffraction (SAED), and measurements of zeta potential, it was determined that the mechanism of stabilization i.e. choice of stabilizing agent can promote different crystalline arrangement within SeNPs. The BSA proved as a more effective stabilizing agent for SeNPs, as it provides obtaining the smaller, more uniform, and amorphous nanoparticles.
PB  - Beograd : Savez inženjera i tehničara Srbije
T2  - Tehnika
T1  - Uticaj stabilizatora na fizičkohemijska svojstva nanočestica selena dobijenih hemijskom redukcijom
SP  - 137
EP  - 143
VL  - 76
IS  - 2
DO  - 10.5937/tehnika2102137F
UR  - https://hdl.handle.net/21.15107/rcub_dais_12358
ER  - 

@article{
author = "Filipović, Nenad and Stojanović, Zoran and Stevanović, Magdalena",
year = "2021",
abstract = "Nanočestice selena (SeNPs) su specifična forma ovog elementa koja je u poslednje vreme postala predmet brojnih istraživanja, pogotovo u oblasti biomedicine. Do sada je razvijeno više metoda sinteze SeNPs, među kojima se najčešće koriste one koje podrazumevaju redukciju iz njegovih jedinjenja. U ovom radu ispitan je uticaj dva stabilizatora na morfologiju, veličinu i kristalno uređenje SeNPs dobijenih redukcijom natrijum selenita askorbinskom kiselinom. Kao stabilizatori SeNPs korišćeni su goveđi serum albumin (BSA) ili poliglutaminska kiselina (PGA). Na osnovu rezultata dobijenih metodama skenirajuće elektronske mikroskopije (FESEM), transmisione elektronske mikroskopije (TEM), energetske disperzione spektroskopije (EDS), elektronske difrakcije sa selektovane površine (SAED) i merenjem zeta potencijala, utvrđeno je da mehanizam stabilizacije tj. izbor stabilizatora može prouzrokovati različito kristalno uređenje unutar SeNPs. BSA se pokazao kao efikasniji stabilizator jer omogućuje dobijanje uniformnijih, manjih i amorfnih nanočestica selena., Selenium nanoparticles (SeNPs) are specific form of this element that has recently become the subject of numerous research, especially in the field of biomedicine. Several synthesis procedures for obtaining SeNPs have been developed so far, among those including reduction of selenium salts are the most frequently used. In this work, it is examined the effect of two stabilizing agents on morphology, size, and crystallinity of obtained SeNPs. For this purpose, bovine serum albumin (BSA) and polyglutamic acid (PGA) were used as stabilizing agents while reduction of sodium selenite with ascorbic acid was elected as a synthesis procedure. Based on the results obtained from scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), selected area electron diffraction (SAED), and measurements of zeta potential, it was determined that the mechanism of stabilization i.e. choice of stabilizing agent can promote different crystalline arrangement within SeNPs. The BSA proved as a more effective stabilizing agent for SeNPs, as it provides obtaining the smaller, more uniform, and amorphous nanoparticles.",
publisher = "Beograd : Savez inženjera i tehničara Srbije",
journal = "Tehnika",
title = "Uticaj stabilizatora na fizičkohemijska svojstva nanočestica selena dobijenih hemijskom redukcijom",
pages = "137-143",
volume = "76",
number = "2",
doi = "10.5937/tehnika2102137F",
url = "https://hdl.handle.net/21.15107/rcub_dais_12358"
}

Filipović, N., Stojanović, Z.,& Stevanović, M.. (2021). Uticaj stabilizatora na fizičkohemijska svojstva nanočestica selena dobijenih hemijskom redukcijom. in Tehnika
Beograd : Savez inženjera i tehničara Srbije., 76(2), 137-143.
https://doi.org/10.5937/tehnika2102137F
https://hdl.handle.net/21.15107/rcub_dais_12358

Filipović N, Stojanović Z, Stevanović M. Uticaj stabilizatora na fizičkohemijska svojstva nanočestica selena dobijenih hemijskom redukcijom. in Tehnika. 2021;76(2):137-143.
doi:10.5937/tehnika2102137F
https://hdl.handle.net/21.15107/rcub_dais_12358 .

Filipović, Nenad, Stojanović, Zoran, Stevanović, Magdalena, "Uticaj stabilizatora na fizičkohemijska svojstva nanočestica selena dobijenih hemijskom redukcijom" in Tehnika, 76, no. 2 (2021):137-143,
https://doi.org/10.5937/tehnika2102137F .,
https://hdl.handle.net/21.15107/rcub_dais_12358 .

TY  - CONF
AU  - Marković, Smilja
AU  - Stojanović, Zoran S.
AU  - Veselinović, Ljiljana
AU  - Simić, Danica
AU  - Samolov, Aleksandra
AU  - Stojković Simatović, Ivana
PY  - 2020
UR  - https://dais.sanu.ac.rs/123456789/10038
AB  - Radar-absorbent materials, used in stealth technology for defense aircrafts, vehicles, satellites, etc. from radar detection, are commonly based on graphite or semiconductive particles embedded in a polymer matrix. In this study, we employed Co2+ ion-substitution to improve Vis-NIR reflectivity of hydroxyapatite (Ca10(PO4)6(OH)2, HAP) powder. HAP:Co with nominally 5 at.% of Co was prepared with hydrothermal processing of a precipitate. Synthesized powder was characterized by XRD, Raman and ATR-FTIR spectroscopy, FE-SEM and TEM. Thermal stability of HAP:Co powder was examined by simultaneous TG-DTA analyzer. To modify its optical properties and obtain powders with a varietty of color tone, the HAP:Co powder was calcined at 800, 1000, and 1100 °C, in an air atmosphere, for 1 hour. Afterward, the calcined particles were used to prepare composites with poly(vinyl butyral), (PVB); the concentration range was 1 wt.% of the HAP:Co in PVB. The composite coatings, in the form of thin films on glass, were prepared by the solvent-casting technique, using ethanol as a fast evaporating solvent. Firstly, the HAP:Co particles were dispersed in ethanol, then PVB was added (Mowital B30H) and dissolved. To evaporate the solvent before spectrophotometric measurements, the coatings on glass were dried at room temperature for 72 hours. To comprehend optical properties of the coatings, diffuse reflection, transmission, and color coordinates were determined. We found that calcined HAP:Co particles have potential to be used in the formulation of coatings for camouflage protection.
PB  - Belgrade : Military Technical Institute
C3  - 9th International Scientific Conference on Defensive Technologies : OTEH2020, Belgrade, Serbia, 15-16 October 2020
T1  - HAp:Co as tunable VIS-NIR reflective pigment
SP  - 475
EP  - 480
UR  - https://hdl.handle.net/21.15107/rcub_dais_10038
ER  - 

@conference{
author = "Marković, Smilja and Stojanović, Zoran S. and Veselinović, Ljiljana and Simić, Danica and Samolov, Aleksandra and Stojković Simatović, Ivana",
year = "2020",
abstract = "Radar-absorbent materials, used in stealth technology for defense aircrafts, vehicles, satellites, etc. from radar detection, are commonly based on graphite or semiconductive particles embedded in a polymer matrix. In this study, we employed Co2+ ion-substitution to improve Vis-NIR reflectivity of hydroxyapatite (Ca10(PO4)6(OH)2, HAP) powder. HAP:Co with nominally 5 at.% of Co was prepared with hydrothermal processing of a precipitate. Synthesized powder was characterized by XRD, Raman and ATR-FTIR spectroscopy, FE-SEM and TEM. Thermal stability of HAP:Co powder was examined by simultaneous TG-DTA analyzer. To modify its optical properties and obtain powders with a varietty of color tone, the HAP:Co powder was calcined at 800, 1000, and 1100 °C, in an air atmosphere, for 1 hour. Afterward, the calcined particles were used to prepare composites with poly(vinyl butyral), (PVB); the concentration range was 1 wt.% of the HAP:Co in PVB. The composite coatings, in the form of thin films on glass, were prepared by the solvent-casting technique, using ethanol as a fast evaporating solvent. Firstly, the HAP:Co particles were dispersed in ethanol, then PVB was added (Mowital B30H) and dissolved. To evaporate the solvent before spectrophotometric measurements, the coatings on glass were dried at room temperature for 72 hours. To comprehend optical properties of the coatings, diffuse reflection, transmission, and color coordinates were determined. We found that calcined HAP:Co particles have potential to be used in the formulation of coatings for camouflage protection.",
publisher = "Belgrade : Military Technical Institute",
journal = "9th International Scientific Conference on Defensive Technologies : OTEH2020, Belgrade, Serbia, 15-16 October 2020",
title = "HAp:Co as tunable VIS-NIR reflective pigment",
pages = "475-480",
url = "https://hdl.handle.net/21.15107/rcub_dais_10038"
}

Marković, S., Stojanović, Z. S., Veselinović, L., Simić, D., Samolov, A.,& Stojković Simatović, I.. (2020). HAp:Co as tunable VIS-NIR reflective pigment. in 9th International Scientific Conference on Defensive Technologies : OTEH2020, Belgrade, Serbia, 15-16 October 2020
Belgrade : Military Technical Institute., 475-480.
https://hdl.handle.net/21.15107/rcub_dais_10038

Marković S, Stojanović ZS, Veselinović L, Simić D, Samolov A, Stojković Simatović I. HAp:Co as tunable VIS-NIR reflective pigment. in 9th International Scientific Conference on Defensive Technologies : OTEH2020, Belgrade, Serbia, 15-16 October 2020. 2020;:475-480.
https://hdl.handle.net/21.15107/rcub_dais_10038 .

Marković, Smilja, Stojanović, Zoran S., Veselinović, Ljiljana, Simić, Danica, Samolov, Aleksandra, Stojković Simatović, Ivana, "HAp:Co as tunable VIS-NIR reflective pigment" in 9th International Scientific Conference on Defensive Technologies : OTEH2020, Belgrade, Serbia, 15-16 October 2020 (2020):475-480,
https://hdl.handle.net/21.15107/rcub_dais_10038 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Mančić, Lidija
AU  - Vuković, Marina
AU  - Stojanović, Zoran S.
AU  - Nikolić, Marko G.
AU  - Škapin, Srečo Davor
AU  - Jovanović, Sonja
AU  - Veselinović, Ljiljana
AU  - Uskoković, Vuk
AU  - Lazić, Snežana
AU  - Marković, Smilja
AU  - Lazarević, Miloš M.
AU  - Uskoković, Dragan
PY  - 2019
UR  - https://www.nature.com/articles/s41598-019-52885-0
UR  - https://dais.sanu.ac.rs/123456789/6950
AB  - Taking advantage of the flexibility of the apatite structure, nano- and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE3+ = Gd, Eu, Yb, Tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at T ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P63/m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca2+ with smaller RE3+ ions at both cation positions. The FTIR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:RE3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λex = 370 nm) due to an increased concentration of defects. The “up”- and the “down”-conversion spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders showed characteristic transitions of Tm3+ and Eu3+, respectively. Furthermore, in contrast to diamagnetic HAp, all HAp:RE3+ powders exhibited paramagnetic behavior. Cell viability tests of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders in human dental pulp stem cell cultures indicated their good biocompatibility.
PB  - Springer Nature
T2  - Scientific Reports
T1  - Rare-earth (Gd 3+ ,Yb 3+ /Tm 3+ , Eu 3+ ) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging
SP  - 1
EP  - 15
VL  - 9
IS  - 1
DO  - 10.1038/s41598-019-52885-0
UR  - https://hdl.handle.net/21.15107/rcub_dais_6950
ER  - 

@article{
author = "Ignjatović, Nenad and Mančić, Lidija and Vuković, Marina and Stojanović, Zoran S. and Nikolić, Marko G. and Škapin, Srečo Davor and Jovanović, Sonja and Veselinović, Ljiljana and Uskoković, Vuk and Lazić, Snežana and Marković, Smilja and Lazarević, Miloš M. and Uskoković, Dragan",
year = "2019",
abstract = "Taking advantage of the flexibility of the apatite structure, nano- and micro-particles of hydroxyapatite (HAp) were doped with different combinations of rare earth ions (RE3+ = Gd, Eu, Yb, Tm) to achieve a synergy among their magnetic and optical properties and to enable their application in preventive medicine, particularly diagnostics based on multimodal imaging. All powders were synthesized through hydrothermal processing at T ≤ 200 °C. An X-ray powder diffraction analysis showed that all powders crystallized in P63/m space group of the hexagonal crystal structure. The refined unit-cell parameters reflected a decrease in the unit cell volume as a result of the partial substitution of Ca2+ with smaller RE3+ ions at both cation positions. The FTIR analysis additionally suggested that a synergy may exist solely in the triply doped system, where the lattice symmetry and vibration modes become more coherent than in the singly or doubly doped systems. HAp:RE3+ optical characterization revealed a change in the energy band gap and the appearance of a weak blue luminescence (λex = 370 nm) due to an increased concentration of defects. The “up”- and the “down”-conversion spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders showed characteristic transitions of Tm3+ and Eu3+, respectively. Furthermore, in contrast to diamagnetic HAp, all HAp:RE3+ powders exhibited paramagnetic behavior. Cell viability tests of HAp:Gd/Yb/Tm and HAp:Gd/Eu powders in human dental pulp stem cell cultures indicated their good biocompatibility.",
publisher = "Springer Nature",
journal = "Scientific Reports",
title = "Rare-earth (Gd 3+ ,Yb 3+ /Tm 3+ , Eu 3+ ) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging",
pages = "1-15",
volume = "9",
number = "1",
doi = "10.1038/s41598-019-52885-0",
url = "https://hdl.handle.net/21.15107/rcub_dais_6950"
}

Ignjatović, N., Mančić, L., Vuković, M., Stojanović, Z. S., Nikolić, M. G., Škapin, S. D., Jovanović, S., Veselinović, L., Uskoković, V., Lazić, S., Marković, S., Lazarević, M. M.,& Uskoković, D.. (2019). Rare-earth (Gd 3+ ,Yb 3+ /Tm 3+ , Eu 3+ ) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging. in Scientific Reports
Springer Nature., 9(1), 1-15.
https://doi.org/10.1038/s41598-019-52885-0
https://hdl.handle.net/21.15107/rcub_dais_6950

Ignjatović N, Mančić L, Vuković M, Stojanović ZS, Nikolić MG, Škapin SD, Jovanović S, Veselinović L, Uskoković V, Lazić S, Marković S, Lazarević MM, Uskoković D. Rare-earth (Gd 3+ ,Yb 3+ /Tm 3+ , Eu 3+ ) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging. in Scientific Reports. 2019;9(1):1-15.
doi:10.1038/s41598-019-52885-0
https://hdl.handle.net/21.15107/rcub_dais_6950 .

Ignjatović, Nenad, Mančić, Lidija, Vuković, Marina, Stojanović, Zoran S., Nikolić, Marko G., Škapin, Srečo Davor, Jovanović, Sonja, Veselinović, Ljiljana, Uskoković, Vuk, Lazić, Snežana, Marković, Smilja, Lazarević, Miloš M., Uskoković, Dragan, "Rare-earth (Gd 3+ ,Yb 3+ /Tm 3+ , Eu 3+ ) co-doped hydroxyapatite as magnetic, up-conversion and down-conversion materials for multimodal imaging" in Scientific Reports, 9, no. 1 (2019):1-15,
https://doi.org/10.1038/s41598-019-52885-0 .,
https://hdl.handle.net/21.15107/rcub_dais_6950 .

TY  - CONF
AU  - Ignjatović, Nenad
AU  - Mančić, Lidija
AU  - Vuković, Marina
AU  - Stojanović, Zoran S.
AU  - Nikolić, Marko G.
AU  - Škapin, Srečo Davor
AU  - Jovanović, Sonja
AU  - Veselinović, Ljiljana
AU  - Lazić, Snežana
AU  - Marković, Smilja
AU  - Uskoković, Dragan
PY  - 2019
UR  - https://dais.sanu.ac.rs/123456789/6676
AB  - Hydroxyapatite (HAp) has been widely used as bone reconstruction materials due to their similarity to bone tissue. The improvement of HAp properties was achieved by doping its crystal lattice with different ions. Lanthanides, i.e. Rare Earth Elements (RE) are also suitable for doping HAp. The aim of the presented research was to investigate the possibility of creating lumino-magnetic particles of HAp doped with gadolinium (Gd3+) ions and co-doped with ytterbium/thulium (Yb3+/Tm3+) or europium (Eu3+) ions for potential use in multimodal imaging (MI). Pure HAp (Ca5(PO4)3(OH)), magnetic HAp:Gd (Ca4.85Gd0.15(PO4)3(OH)), and lumino-magnetic HAp:Gd/Yb/Tm (Ca4.85Gd0.03Yb0.1Tm0.02(PO4)3(OH)) and HAp:Gd/Eu (Ca4.94Gd0.02Eu0.04(PO4)3(OH)) particles were synthesized using emulsification process and hydrothermal processing. All synthesized particles had an elongated shape and exhibited a paramagnetic behavior. Reduction of the unit cell volume as a result of replacement of Ca2+ ions by ions with a smaller ionic radius (Gd3+, Yb3+, Tm3+, Eu3+) confirmed by using XRD and Rietveld refined plots. The energy band gap values of the synthesized samples range from 4.93 to 3.18 eV and decrease in the following order: HAp:Gd >HAp>HAp:Gd/Eu>HAp:Gd/Yb/Tm. The results of photoluminescence emission spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu particles showed characteristic transitions of Tm3+ and Eu3+, respectively.
PB  - Belgrade : Materials Research Society of Serbia
C3  - Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019
T1  - Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents
SP  - 76
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_dais_6676
ER  - 

@conference{
author = "Ignjatović, Nenad and Mančić, Lidija and Vuković, Marina and Stojanović, Zoran S. and Nikolić, Marko G. and Škapin, Srečo Davor and Jovanović, Sonja and Veselinović, Ljiljana and Lazić, Snežana and Marković, Smilja and Uskoković, Dragan",
year = "2019",
abstract = "Hydroxyapatite (HAp) has been widely used as bone reconstruction materials due to their similarity to bone tissue. The improvement of HAp properties was achieved by doping its crystal lattice with different ions. Lanthanides, i.e. Rare Earth Elements (RE) are also suitable for doping HAp. The aim of the presented research was to investigate the possibility of creating lumino-magnetic particles of HAp doped with gadolinium (Gd3+) ions and co-doped with ytterbium/thulium (Yb3+/Tm3+) or europium (Eu3+) ions for potential use in multimodal imaging (MI). Pure HAp (Ca5(PO4)3(OH)), magnetic HAp:Gd (Ca4.85Gd0.15(PO4)3(OH)), and lumino-magnetic HAp:Gd/Yb/Tm (Ca4.85Gd0.03Yb0.1Tm0.02(PO4)3(OH)) and HAp:Gd/Eu (Ca4.94Gd0.02Eu0.04(PO4)3(OH)) particles were synthesized using emulsification process and hydrothermal processing. All synthesized particles had an elongated shape and exhibited a paramagnetic behavior. Reduction of the unit cell volume as a result of replacement of Ca2+ ions by ions with a smaller ionic radius (Gd3+, Yb3+, Tm3+, Eu3+) confirmed by using XRD and Rietveld refined plots. The energy band gap values of the synthesized samples range from 4.93 to 3.18 eV and decrease in the following order: HAp:Gd >HAp>HAp:Gd/Eu>HAp:Gd/Yb/Tm. The results of photoluminescence emission spectra of HAp:Gd/Yb/Tm and HAp:Gd/Eu particles showed characteristic transitions of Tm3+ and Eu3+, respectively.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019",
title = "Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents",
pages = "76-76",
url = "https://hdl.handle.net/21.15107/rcub_dais_6676"
}

Ignjatović, N., Mančić, L., Vuković, M., Stojanović, Z. S., Nikolić, M. G., Škapin, S. D., Jovanović, S., Veselinović, L., Lazić, S., Marković, S.,& Uskoković, D.. (2019). Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents. in Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019
Belgrade : Materials Research Society of Serbia., 76-76.
https://hdl.handle.net/21.15107/rcub_dais_6676

Ignjatović N, Mančić L, Vuković M, Stojanović ZS, Nikolić MG, Škapin SD, Jovanović S, Veselinović L, Lazić S, Marković S, Uskoković D. Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents. in Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019. 2019;:76-76.
https://hdl.handle.net/21.15107/rcub_dais_6676 .

Ignjatović, Nenad, Mančić, Lidija, Vuković, Marina, Stojanović, Zoran S., Nikolić, Marko G., Škapin, Srečo Davor, Jovanović, Sonja, Veselinović, Ljiljana, Lazić, Snežana, Marković, Smilja, Uskoković, Dragan, "Hydroxyapatite nano particles doped with Gd3+, Yb3+/Tm3+ and Eu3+ as lumino-magnetic multimodal contrast agents" in Programme and The Book of abstracts / Twenty-first Annual Conference YUCOMAT 2019 & Eleventh World Round Table Conference on Sintering WRTCS 2019, Herceg Novi, Montenegro, September 2-6, 2019 (2019):76-76,
https://hdl.handle.net/21.15107/rcub_dais_6676 .

TY  - CONF
AU  - Dinić, Ivana
AU  - Vuković, Marina
AU  - Ignjatović, Nenad
AU  - Stojanović, Zoran S.
AU  - Škapin, Srečo Davor
AU  - Veselinović, Ljiljana
AU  - Mančić, Lidija
PY  - 2018
UR  - https://dais.sanu.ac.rs/123456789/4118
AB  - Lantanide dual-doped hydroxyapatite (HaP:Ln) is currently the subject of numerous studies in reconstructive medicine. Designed in form of hybrid nanoparticles which have magnetic and luminescent properties HaP:Ln (where Ln=Gd/Eu or Gd/Yb/Tm) is capable to enhance signal detection. Beside it, due biodegradable properties it is suitable for use in bone tissue engineering and target drug delivery. For such a promising approach, doping of a HAp matrix is performed with Gd/Eu and Gd/Yb/Tm during hydrothermal synthesis using EDTA as chelating agent. Morphological and structural characteristics of the particles were obtained using X-ray powder diffraction (XRPD), scanning and transmission electron microscopy (SEM/TEM), energy dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR) and photoluminescence (PL). The results show that needle-like nano- or micro- particles were obtained in all systems. Their phase composition and uniform distribution of dopants were confirmed by the structural refinement of the XRPD data and luminescence response from Eu and Tb (λex = 370, 394 and 977 nm).
PB  - Belgrade : Serbian Ceramic Society
C3  - Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018
T1  - Lanthanide doped hydroxyapatite for multimodal imaging
SP  - 71
EP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_dais_4118
ER  - 

@conference{
author = "Dinić, Ivana and Vuković, Marina and Ignjatović, Nenad and Stojanović, Zoran S. and Škapin, Srečo Davor and Veselinović, Ljiljana and Mančić, Lidija",
year = "2018",
abstract = "Lantanide dual-doped hydroxyapatite (HaP:Ln) is currently the subject of numerous studies in reconstructive medicine. Designed in form of hybrid nanoparticles which have magnetic and luminescent properties HaP:Ln (where Ln=Gd/Eu or Gd/Yb/Tm) is capable to enhance signal detection. Beside it, due biodegradable properties it is suitable for use in bone tissue engineering and target drug delivery. For such a promising approach, doping of a HAp matrix is performed with Gd/Eu and Gd/Yb/Tm during hydrothermal synthesis using EDTA as chelating agent. Morphological and structural characteristics of the particles were obtained using X-ray powder diffraction (XRPD), scanning and transmission electron microscopy (SEM/TEM), energy dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR) and photoluminescence (PL). The results show that needle-like nano- or micro- particles were obtained in all systems. Their phase composition and uniform distribution of dopants were confirmed by the structural refinement of the XRPD data and luminescence response from Eu and Tb (λex = 370, 394 and 977 nm).",
publisher = "Belgrade : Serbian Ceramic Society",
journal = "Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018",
title = "Lanthanide doped hydroxyapatite for multimodal imaging",
pages = "71-71",
url = "https://hdl.handle.net/21.15107/rcub_dais_4118"
}

Dinić, I., Vuković, M., Ignjatović, N., Stojanović, Z. S., Škapin, S. D., Veselinović, L.,& Mančić, L.. (2018). Lanthanide doped hydroxyapatite for multimodal imaging. in Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018
Belgrade : Serbian Ceramic Society., 71-71.
https://hdl.handle.net/21.15107/rcub_dais_4118

Dinić I, Vuković M, Ignjatović N, Stojanović ZS, Škapin SD, Veselinović L, Mančić L. Lanthanide doped hydroxyapatite for multimodal imaging. in Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018. 2018;:71-71.
https://hdl.handle.net/21.15107/rcub_dais_4118 .

Dinić, Ivana, Vuković, Marina, Ignjatović, Nenad, Stojanović, Zoran S., Škapin, Srečo Davor, Veselinović, Ljiljana, Mančić, Lidija, "Lanthanide doped hydroxyapatite for multimodal imaging" in Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018 (2018):71-71,
https://hdl.handle.net/21.15107/rcub_dais_4118 .

TY  - DATA
AU  - Ajdačić, Vladimir
AU  - Nikolić, Andrea
AU  - Simić, Stefan
AU  - Manojlović, Dragan D.
AU  - Stojanović, Zoran S.
AU  - Nikodinović Runić, Jasmina
AU  - Opsenica, Igor
PY  - 2018
UR  - https://www.thieme-connect.de/media/synthesis/201801/supmat/sup_ss-2017-t0452-op_10-1055_s-0036-1590892.pdf
UR  - https://dais.sanu.ac.rs/123456789/3773
AB  - 1H NMR and 13C NMR Spectra of Products; GC‒MS
T2  - Synthesis
T1  - Supporting Information for Ajdačić Vladimir, Nikolić Andrea, Simić Stefan, Manojlović Dragan D., Stojanović Zoran S., Nikodinović Runić Jasmina, Opsenica Igor M., "Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst" Synthesis (Germany), 50, no. 1 (2018),
https://doi.org/10.1055/s-0036-1590892
VL  - 50
IS  - 01
UR  - https://hdl.handle.net/21.15107/rcub_dais_3773
ER  - 

@misc{
author = "Ajdačić, Vladimir and Nikolić, Andrea and Simić, Stefan and Manojlović, Dragan D. and Stojanović, Zoran S. and Nikodinović Runić, Jasmina and Opsenica, Igor",
year = "2018",
abstract = "1H NMR and 13C NMR Spectra of Products; GC‒MS",
journal = "Synthesis",
title = "Supporting Information for Ajdačić Vladimir, Nikolić Andrea, Simić Stefan, Manojlović Dragan D., Stojanović Zoran S., Nikodinović Runić Jasmina, Opsenica Igor M., "Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst" Synthesis (Germany), 50, no. 1 (2018),
https://doi.org/10.1055/s-0036-1590892",
volume = "50",
number = "01",
url = "https://hdl.handle.net/21.15107/rcub_dais_3773"
}

Ajdačić, V., Nikolić, A., Simić, S., Manojlović, D. D., Stojanović, Z. S., Nikodinović Runić, J.,& Opsenica, I.. (2018). Supporting Information for Ajdačić Vladimir, Nikolić Andrea, Simić Stefan, Manojlović Dragan D., Stojanović Zoran S., Nikodinović Runić Jasmina, Opsenica Igor M., "Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst" Synthesis (Germany), 50, no. 1 (2018),
https://doi.org/10.1055/s-0036-1590892. in Synthesis, 50(01).
https://hdl.handle.net/21.15107/rcub_dais_3773

Ajdačić V, Nikolić A, Simić S, Manojlović DD, Stojanović ZS, Nikodinović Runić J, Opsenica I. Supporting Information for Ajdačić Vladimir, Nikolić Andrea, Simić Stefan, Manojlović Dragan D., Stojanović Zoran S., Nikodinović Runić Jasmina, Opsenica Igor M., "Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst" Synthesis (Germany), 50, no. 1 (2018),
https://doi.org/10.1055/s-0036-1590892. in Synthesis. 2018;50(01).
https://hdl.handle.net/21.15107/rcub_dais_3773 .

Ajdačić, Vladimir, Nikolić, Andrea, Simić, Stefan, Manojlović, Dragan D., Stojanović, Zoran S., Nikodinović Runić, Jasmina, Opsenica, Igor, "Supporting Information for Ajdačić Vladimir, Nikolić Andrea, Simić Stefan, Manojlović Dragan D., Stojanović Zoran S., Nikodinović Runić Jasmina, Opsenica Igor M., "Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst" Synthesis (Germany), 50, no. 1 (2018),
https://doi.org/10.1055/s-0036-1590892" in Synthesis, 50, no. 01 (2018),
https://hdl.handle.net/21.15107/rcub_dais_3773 .

TY  - JOUR
AU  - Ajdačić, Vladimir
AU  - Nikolić, Andrea
AU  - Simić, Stefan
AU  - Manojlović, Dragan D.
AU  - Stojanović, Zoran S.
AU  - Nikodinović Runić, Jasmina
AU  - Opsenica, Igor M.
PY  - 2018
UR  - https://dais.sanu.ac.rs/123456789/3746
AB  - A facile decarbonylation reaction of a variety of aromatic and heteroaromatic aldehydes using maghemite-supported palladium catalyst has been developed. The magnetic properties of catalyst facilitated an easy and efficient recovery of the catalyst from the reaction mixture using an external magnet. It was found that the catalyst could be reused up to four consecutive catalytic runs without a significant change in activity. In addition, the catalyst was also very effective in the dehalogenation of aryl halides. This is the first report on efficient utilization of directly immobilized Pd on maghemite in decarbonylation and dehalogenation reactions. © Georg Thieme Verlag Stuttgart.New York.
PB  - Stuttgart : Georg Thieme Verlag KG
T2  - Synthesis (Germany)
T1  - Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst
EP  - 126
VL  - 50
IS  - 1
DO  - 10.1055/s-0036-1590892
UR  - https://hdl.handle.net/21.15107/rcub_dais_3746
ER  - 

@article{
author = "Ajdačić, Vladimir and Nikolić, Andrea and Simić, Stefan and Manojlović, Dragan D. and Stojanović, Zoran S. and Nikodinović Runić, Jasmina and Opsenica, Igor M.",
year = "2018",
abstract = "A facile decarbonylation reaction of a variety of aromatic and heteroaromatic aldehydes using maghemite-supported palladium catalyst has been developed. The magnetic properties of catalyst facilitated an easy and efficient recovery of the catalyst from the reaction mixture using an external magnet. It was found that the catalyst could be reused up to four consecutive catalytic runs without a significant change in activity. In addition, the catalyst was also very effective in the dehalogenation of aryl halides. This is the first report on efficient utilization of directly immobilized Pd on maghemite in decarbonylation and dehalogenation reactions. © Georg Thieme Verlag Stuttgart.New York.",
publisher = "Stuttgart : Georg Thieme Verlag KG",
journal = "Synthesis (Germany)",
title = "Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst",
pages = "126",
volume = "50",
number = "1",
doi = "10.1055/s-0036-1590892",
url = "https://hdl.handle.net/21.15107/rcub_dais_3746"
}

Ajdačić, V., Nikolić, A., Simić, S., Manojlović, D. D., Stojanović, Z. S., Nikodinović Runić, J.,& Opsenica, I. M.. (2018). Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst. in Synthesis (Germany)
Stuttgart : Georg Thieme Verlag KG., 50(1).
https://doi.org/10.1055/s-0036-1590892
https://hdl.handle.net/21.15107/rcub_dais_3746

Ajdačić V, Nikolić A, Simić S, Manojlović DD, Stojanović ZS, Nikodinović Runić J, Opsenica IM. Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst. in Synthesis (Germany). 2018;50(1):null-126.
doi:10.1055/s-0036-1590892
https://hdl.handle.net/21.15107/rcub_dais_3746 .

Ajdačić, Vladimir, Nikolić, Andrea, Simić, Stefan, Manojlović, Dragan D., Stojanović, Zoran S., Nikodinović Runić, Jasmina, Opsenica, Igor M., "Decarbonylation of Aromatic Aldehydes and Dehalogenation of Aryl Halides Using Maghemite-Supported Palladium Catalyst" in Synthesis (Germany), 50, no. 1 (2018),
https://doi.org/10.1055/s-0036-1590892 .,
https://hdl.handle.net/21.15107/rcub_dais_3746 .