TY  - JOUR
AU  - Milošević, Dragana
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2017
UR  - https://scindeks.ceon.rs/article.aspx?artid=0040-21761701011M
UR  - http://www.ncbi.nlm.nih.gov/pubmed/0040-21761701011M
UR  - https://dais.sanu.ac.rs/123456789/3358
AB  - Thanks to its special caracteristics, such as relativly easy chemical modification of structure and surface, calciumphosphates (CaP) especially hydroxyapatite (HAp) is found widely used in various fields of biomedicine. Beside of the ease chemical modification, which includes metal doping, enhancement of properties of the HAp can be accomplished by combinations with various therapeutic and/or diagnostic agents. Materials base on CaP or HAp can be used in bone tissue engineering for reconstruction of bone damages as bone graft substitute as well as bone drug delivery systems. The improved properties of HAp were realized by doping with different elements (Co, Zn, Fe, Eu, Gd etc.). Synthesis, characterization and application of nanoparticulate multifunctional and hybrid materials based on CaP and HAp, is currently receiving tremendous attention. Multifunctional hybrid systems based on HAp could integrate medical preventive and regenerative potential in a single particle.
AB  - Zahvaljujući svojim specifičnim svojstvima, kao što su modifikacija strukture i provšine, kalcijum-fosfati (CaP) posebno hidroksiapatit (HAp) se široko upotrebljavaju u mnogim oblastima biomedicine. Pored hemijske modifikacije, koja uključuje dopiranje metalima, unapređenje svojstava HAp-a se može postići kombinovanjem sa velikim brojem polimera kao i terapeutskih i/ili dijagnostičkih agenasa. Materijali na bazi CaP i HAp-a mogu se koristiti u inženjerstvu koštanog tkiva za rekonstrukciju kostiju kao graftovi ali i kao sistemi za dostavu lekova, gena, antikancer agenasa, itd. Unapređena svojstva HAp-a ostvarena su dopiranjem sa različitim elementima (Co, Zn, Fe, Eu, Gd itd.). Sinteza, karakterizacija i primena nanočestičnih multifunkcionalnih i hibridnih sistema na bazi CaP i HAp-a predstavlja istraživački izazov mnogim istraživačkim grupama. Multifunkcionalne i hibridne čestice na bazi HAp-a mogu da objedine medicinski preventivne/dijagnostičke i regenerativne potencijale u jednoj čestici.
PB  - Belgrade : Union of Engineers and Technicians of Serbia
T2  - Tehnika
T1  - Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine
T1  - Multifunkcionalni i hibridni sistemi na bazi kalcijum fosfata i hidroksiapatita za preventivnu i regenerativnu medicinu
SP  - 11
EP  - 24
VL  - 72
IS  - 1
DO  - 10.5937/tehnika1701011M
UR  - https://hdl.handle.net/21.15107/rcub_dais_3358
ER  - 

@article{
author = "Milošević, Dragana and Ignjatović, Nenad and Uskoković, Dragan",
year = "2017",
abstract = "Thanks to its special caracteristics, such as relativly easy chemical modification of structure and surface, calciumphosphates (CaP) especially hydroxyapatite (HAp) is found widely used in various fields of biomedicine. Beside of the ease chemical modification, which includes metal doping, enhancement of properties of the HAp can be accomplished by combinations with various therapeutic and/or diagnostic agents. Materials base on CaP or HAp can be used in bone tissue engineering for reconstruction of bone damages as bone graft substitute as well as bone drug delivery systems. The improved properties of HAp were realized by doping with different elements (Co, Zn, Fe, Eu, Gd etc.). Synthesis, characterization and application of nanoparticulate multifunctional and hybrid materials based on CaP and HAp, is currently receiving tremendous attention. Multifunctional hybrid systems based on HAp could integrate medical preventive and regenerative potential in a single particle., Zahvaljujući svojim specifičnim svojstvima, kao što su modifikacija strukture i provšine, kalcijum-fosfati (CaP) posebno hidroksiapatit (HAp) se široko upotrebljavaju u mnogim oblastima biomedicine. Pored hemijske modifikacije, koja uključuje dopiranje metalima, unapređenje svojstava HAp-a se može postići kombinovanjem sa velikim brojem polimera kao i terapeutskih i/ili dijagnostičkih agenasa. Materijali na bazi CaP i HAp-a mogu se koristiti u inženjerstvu koštanog tkiva za rekonstrukciju kostiju kao graftovi ali i kao sistemi za dostavu lekova, gena, antikancer agenasa, itd. Unapređena svojstva HAp-a ostvarena su dopiranjem sa različitim elementima (Co, Zn, Fe, Eu, Gd itd.). Sinteza, karakterizacija i primena nanočestičnih multifunkcionalnih i hibridnih sistema na bazi CaP i HAp-a predstavlja istraživački izazov mnogim istraživačkim grupama. Multifunkcionalne i hibridne čestice na bazi HAp-a mogu da objedine medicinski preventivne/dijagnostičke i regenerativne potencijale u jednoj čestici.",
publisher = "Belgrade : Union of Engineers and Technicians of Serbia",
journal = "Tehnika",
title = "Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine, Multifunkcionalni i hibridni sistemi na bazi kalcijum fosfata i hidroksiapatita za preventivnu i regenerativnu medicinu",
pages = "11-24",
volume = "72",
number = "1",
doi = "10.5937/tehnika1701011M",
url = "https://hdl.handle.net/21.15107/rcub_dais_3358"
}

Milošević, D., Ignjatović, N.,& Uskoković, D.. (2017). Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine. in Tehnika
Belgrade : Union of Engineers and Technicians of Serbia., 72(1), 11-24.
https://doi.org/10.5937/tehnika1701011M
https://hdl.handle.net/21.15107/rcub_dais_3358

Milošević D, Ignjatović N, Uskoković D. Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine. in Tehnika. 2017;72(1):11-24.
doi:10.5937/tehnika1701011M
https://hdl.handle.net/21.15107/rcub_dais_3358 .

Milošević, Dragana, Ignjatović, Nenad, Uskoković, Dragan, "Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine" in Tehnika, 72, no. 1 (2017):11-24,
https://doi.org/10.5937/tehnika1701011M .,
https://hdl.handle.net/21.15107/rcub_dais_3358 .