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Janićijević, Željko

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orcid::0000-0002-9494-9529
  • Janićijević, Željko (14)
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Author's Bibliography

Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466

Janićijević, Željko; Vujčić, Ivica; Veljović, Đorđe; Vujisić, Miloš; Radovanović, Filip

(2020)

TY  - BOOK
AU  - Janićijević, Željko
AU  - Vujčić, Ivica
AU  - Veljović, Đorđe
AU  - Vujisić, Miloš
AU  - Radovanović, Filip
PY  - 2020
UR  - http://dais.sanu.ac.rs/123456789/6944
AB  - Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.
T2  - Radiation Physics and Chemistry
T1  - Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466
VL  - 166
ER  - 
@book{
author = "Janićijević, Željko and Vujčić, Ivica and Veljović, Đorđe and Vujisić, Miloš and Radovanović, Filip",
year = "2020",
url = "http://dais.sanu.ac.rs/123456789/6944",
abstract = "Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.",
journal = "Radiation Physics and Chemistry",
title = "Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466",
volume = "166"
}
Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M.,& Radovanović, F. (2020). Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466.
Radiation Physics and Chemistry, 166.
Janićijević Ž, Vujčić I, Veljović Đ, Vujisić M, Radovanović F. Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466. Radiation Physics and Chemistry. 2020;166
Janićijević Željko, Vujčić Ivica, Veljović Đorđe, Vujisić Miloš, Radovanović Filip, "Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466" 166 (2020)

Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties

Janićijević, Željko; Vujčić, Ivica; Veljović, Đorđe; Vujisić, Miloš; Radovanović, Filip

(Elsevier, 2020)

TY  - JOUR
AU  - Janićijević, Željko
AU  - Vujčić, Ivica
AU  - Veljović, Đorđe
AU  - Vujisić, Miloš
AU  - Radovanović, Filip
PY  - 2020
UR  - http://www.sciencedirect.com/science/article/pii/S0969806X19301380
UR  - http://dais.sanu.ac.rs/123456789/6943
AB  - Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.
PB  - Elsevier
T2  - Radiation Physics and Chemistry
T1  - Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties
SP  - 108466
VL  - 166
DO  - 10.1016/j.radphyschem.2019.108466
ER  - 
@article{
author = "Janićijević, Željko and Vujčić, Ivica and Veljović, Đorđe and Vujisić, Miloš and Radovanović, Filip",
year = "2020",
url = "http://www.sciencedirect.com/science/article/pii/S0969806X19301380, http://dais.sanu.ac.rs/123456789/6943",
abstract = "Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.",
publisher = "Elsevier",
journal = "Radiation Physics and Chemistry",
title = "Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties",
pages = "108466",
volume = "166",
doi = "10.1016/j.radphyschem.2019.108466"
}
Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M.,& Radovanović, F. (2020). Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties.
Radiation Physics and ChemistryElsevier., 166, 108466.
https://doi.org/10.1016/j.radphyschem.2019.108466
Janićijević Ž, Vujčić I, Veljović Đ, Vujisić M, Radovanović F. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry. 2020;166:108466
Janićijević Željko, Vujčić Ivica, Veljović Đorđe, Vujisić Miloš, Radovanović Filip, "Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties" 166 (2020):108466,
https://doi.org/10.1016/j.radphyschem.2019.108466 .
1

Chapter 1 - Biomedical inorganic nanoparticles: preparation, properties, and perspectives

Stevanović, Magdalena; Lukić, Miodrag J.; Stanković, Ana; Filipović, Nenad; Kuzmanović, Maja; Janićijević, Željko

(Elsevier, 2019)

TY  - CHAP
AU  - Stevanović, Magdalena
AU  - Lukić, Miodrag J.
AU  - Stanković, Ana
AU  - Filipović, Nenad
AU  - Kuzmanović, Maja
AU  - Janićijević, Željko
PY  - 2019
UR  - http://www.sciencedirect.com/science/article/pii/B9780081028148000019
UR  - http://dais.sanu.ac.rs/123456789/5760
AB  - Nanotechnology has great potential in the biomedical field. Among other nanomaterials, inorganic nanoparticles have become extremely important since they possess unique physicochemical properties influenced by their specific surface structure. Consequently, inorganic nanoparticles exhibit enhanced functionalities such as biological response, antibacterial and antiviral properties, as well as optical, magnetic, and electrical responses. They have found applications in medicine, pharmacy, controlled drug delivery, optics, electronics, etc. In this chapter, reports on obtaining different metallic and ceramic inorganic nanoparticles such as gold, silver, selenium, copper, iron, zinc oxide, and hydroxyapatite for biomedical applications will be addressed. For each of these nanosystems, the main challenges regarding the currently achieved functional properties and further perspectives will also be presented.
PB  - Elsevier
T2  - Materials for Biomedical Engineering
T1  - Chapter 1 - Biomedical inorganic nanoparticles: preparation, properties, and perspectives
SP  - 1
EP  - 46
DO  - 10.1016/B978-0-08-102814-8.00001-9
ER  - 
@article{
author = "Stevanović, Magdalena and Lukić, Miodrag J. and Stanković, Ana and Filipović, Nenad and Kuzmanović, Maja and Janićijević, Željko",
year = "2019",
url = "http://www.sciencedirect.com/science/article/pii/B9780081028148000019, http://dais.sanu.ac.rs/123456789/5760",
abstract = "Nanotechnology has great potential in the biomedical field. Among other nanomaterials, inorganic nanoparticles have become extremely important since they possess unique physicochemical properties influenced by their specific surface structure. Consequently, inorganic nanoparticles exhibit enhanced functionalities such as biological response, antibacterial and antiviral properties, as well as optical, magnetic, and electrical responses. They have found applications in medicine, pharmacy, controlled drug delivery, optics, electronics, etc. In this chapter, reports on obtaining different metallic and ceramic inorganic nanoparticles such as gold, silver, selenium, copper, iron, zinc oxide, and hydroxyapatite for biomedical applications will be addressed. For each of these nanosystems, the main challenges regarding the currently achieved functional properties and further perspectives will also be presented.",
publisher = "Elsevier",
journal = "Materials for Biomedical Engineering",
title = "Chapter 1 - Biomedical inorganic nanoparticles: preparation, properties, and perspectives",
pages = "1-46",
doi = "10.1016/B978-0-08-102814-8.00001-9"
}
Stevanović, M., Lukić, M. J., Stanković, A., Filipović, N., Kuzmanović, M.,& Janićijević, Ž. (2019). Chapter 1 - Biomedical inorganic nanoparticles: preparation, properties, and perspectives.
Materials for Biomedical EngineeringElsevier., 1-46.
https://doi.org/10.1016/B978-0-08-102814-8.00001-9
Stevanović M, Lukić MJ, Stanković A, Filipović N, Kuzmanović M, Janićijević Ž. Chapter 1 - Biomedical inorganic nanoparticles: preparation, properties, and perspectives. Materials for Biomedical Engineering. 2019;:1-46
Stevanović Magdalena, Lukić Miodrag J., Stanković Ana, Filipović Nenad, Kuzmanović Maja, Janićijević Željko, "Chapter 1 - Biomedical inorganic nanoparticles: preparation, properties, and perspectives" (2019):1-46,
https://doi.org/10.1016/B978-0-08-102814-8.00001-9 .
1
2

Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles

Janićijević, Željko; Stanković, Ana; Žegura, Bojana; Veljović, Đorđe; Filipič, Metka; Stevanović, Magdalena

(Belgrade : Institute of Technical Sciences of SASA, 2019)

TY  - CONF
AU  - Janićijević, Željko
AU  - Stanković, Ana
AU  - Žegura, Bojana
AU  - Veljović, Đorđe
AU  - Filipič, Metka
AU  - Stevanović, Magdalena
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/6968
AB  - Nanostructured zinc oxides are promising materials for numerous biomedical applications where they can serve as therapeutic agents or tools for sensing and imaging. Despite their favorable properties, wider use of zinc oxide nanoparticles in biomedicine is limited by toxicity issues. Therefore, new synthesis approaches should be devised to obtain zinc oxide nanoparticles which are safe-by-design. We present an innovative low-cost wet precipitation synthesis of gelatin modified zinc oxide nanoparticles at the gel/liquid interface. The diffusion of ammonia through the gelatin hydrogels of different porosities induces precipitation of the product in contact with the surface of the aqueous solution of zinc ions. After thermal treatment of the precipitate, adsorbed organic residues of decomposed gelatin act as modifiers of zinc oxide nanoparticles. We characterized the physicochemical properties of obtained gelatin modified zinc oxide nanoparticles by XRD, FTIR, DTA/TG, and SEM. The synthesized nanoparticles show hexagonal wurtzite structure and form flakelike aggregates. FTIR and DTA/TG analyses indicate that the thermal decomposition of adsorbed gelatin depends on the gelatin content of the hydrogel used in the synthesis. We also examined the viability of HepG2 cells, generation of intracellular reactive oxygen species, and genotoxicity using the MTS, DCFH-DA, and alkaline comet assay, respectively. Fabricated gelatin modified zinc oxide nanoparticles show very low toxicity potential at doses relevant for human exposure.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia
T1  - Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles
SP  - 3
EP  - 3
ER  - 
@conference{
author = "Janićijević, Željko and Stanković, Ana and Žegura, Bojana and Veljović, Đorđe and Filipič, Metka and Stevanović, Magdalena",
year = "2019",
url = "http://dais.sanu.ac.rs/123456789/6968",
abstract = "Nanostructured zinc oxides are promising materials for numerous biomedical applications where they can serve as therapeutic agents or tools for sensing and imaging. Despite their favorable properties, wider use of zinc oxide nanoparticles in biomedicine is limited by toxicity issues. Therefore, new synthesis approaches should be devised to obtain zinc oxide nanoparticles which are safe-by-design. We present an innovative low-cost wet precipitation synthesis of gelatin modified zinc oxide nanoparticles at the gel/liquid interface. The diffusion of ammonia through the gelatin hydrogels of different porosities induces precipitation of the product in contact with the surface of the aqueous solution of zinc ions. After thermal treatment of the precipitate, adsorbed organic residues of decomposed gelatin act as modifiers of zinc oxide nanoparticles. We characterized the physicochemical properties of obtained gelatin modified zinc oxide nanoparticles by XRD, FTIR, DTA/TG, and SEM. The synthesized nanoparticles show hexagonal wurtzite structure and form flakelike aggregates. FTIR and DTA/TG analyses indicate that the thermal decomposition of adsorbed gelatin depends on the gelatin content of the hydrogel used in the synthesis. We also examined the viability of HepG2 cells, generation of intracellular reactive oxygen species, and genotoxicity using the MTS, DCFH-DA, and alkaline comet assay, respectively. Fabricated gelatin modified zinc oxide nanoparticles show very low toxicity potential at doses relevant for human exposure.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia",
title = "Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles",
pages = "3-3"
}
Janićijević, Ž., Stanković, A., Žegura, B., Veljović, Đ., Filipič, M.,& Stevanović, M. (2019). Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles.
Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, SerbiaBelgrade : Institute of Technical Sciences of SASA., 3-3.
Janićijević Ž, Stanković A, Žegura B, Veljović Đ, Filipič M, Stevanović M. Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles. Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia. 2019;:3-3
Janićijević Željko, Stanković Ana, Žegura Bojana, Veljović Đorđe, Filipič Metka, Stevanović Magdalena, "Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles" (2019):3-3

Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs

Janićijević, Željko; Ninkov, Marina; Kataranovski, Milena; Radovanović, Filip

(Wiley, 2019)

TY  - JOUR
AU  - Janićijević, Željko
AU  - Ninkov, Marina
AU  - Kataranovski, Milena
AU  - Radovanović, Filip
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/5253
AB  - Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PB  - Wiley
T2  - Macromolecular Bioscience
T1  - Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs
SP  - 1800322
VL  - 19
DO  - 10.1002/mabi.201800322
ER  - 
@article{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Milena and Radovanović, Filip",
year = "2019",
url = "http://dais.sanu.ac.rs/123456789/5253",
abstract = "Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
publisher = "Wiley",
journal = "Macromolecular Bioscience",
title = "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs",
pages = "1800322",
volume = "19",
doi = "10.1002/mabi.201800322"
}
Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F. (2019). Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.
Macromolecular BioscienceWiley., 19, 1800322.
https://doi.org/10.1002/mabi.201800322
Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. Macromolecular Bioscience. 2019;19:1800322
Janićijević Željko, Ninkov Marina, Kataranovski Milena, Radovanović Filip, "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs" 19 (2019):1800322,
https://doi.org/10.1002/mabi.201800322 .
6
6
6

Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs

Janićijević, Željko; Ninkov, Marina; Kataranovski, Milena; Radovanović, Filip

(Wiley, 2019)

TY  - JOUR
AU  - Janićijević, Željko
AU  - Ninkov, Marina
AU  - Kataranovski, Milena
AU  - Radovanović, Filip
PY  - 2019
UR  - http://dais.sanu.ac.rs/123456789/4714
AB  - Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PB  - Wiley
T2  - Macromolecular Bioscience
T1  - Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs
SP  - 1800322
VL  - 19
DO  - 10.1002/mabi.201800322
ER  - 
@article{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Milena and Radovanović, Filip",
year = "2019",
url = "http://dais.sanu.ac.rs/123456789/4714",
abstract = "Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
publisher = "Wiley",
journal = "Macromolecular Bioscience",
title = "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs",
pages = "1800322",
volume = "19",
doi = "10.1002/mabi.201800322"
}
Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F. (2019). Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.
Macromolecular BioscienceWiley., 19, 1800322.
https://doi.org/10.1002/mabi.201800322
Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. Macromolecular Bioscience. 2019;19:1800322
Janićijević Željko, Ninkov Marina, Kataranovski Milena, Radovanović Filip, "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs" 19 (2019):1800322,
https://doi.org/10.1002/mabi.201800322 .
6
6
6

Supplementary information: Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations

Janićijević, Željko; Radovanović, Filip

(Elsevier, 2018)

TY  - BOOK
AU  - Janićijević, Željko
AU  - Radovanović, Filip
PY  - 2018
UR  - http://dais.sanu.ac.rs/123456789/3392
AB  - Supplementary information. The graphical representations of release kinetics fitting by the Korsmeyer-Peppas and Weber-Morris equations are provided. Masses of released methylene blue under different experimental conditions are given in a separate table. Estimation of membrane pore size at pH = 8 was performed using the gel correlation length model. (PDF).
PB  - Elsevier
T2  - Polymer
T1  - Supplementary information: Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations
VL  - 147
ER  - 
@book{
author = "Janićijević, Željko and Radovanović, Filip",
year = "2018",
url = "http://dais.sanu.ac.rs/123456789/3392",
abstract = "Supplementary information. The graphical representations of release kinetics fitting by the Korsmeyer-Peppas and Weber-Morris equations are provided. Masses of released methylene blue under different experimental conditions are given in a separate table. Estimation of membrane pore size at pH = 8 was performed using the gel correlation length model. (PDF).",
publisher = "Elsevier",
journal = "Polymer",
title = "Supplementary information: Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations",
volume = "147"
}
Janićijević, Ž.,& Radovanović, F. (2018). Supplementary information: Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations.
PolymerElsevier., 147.
Janićijević Ž, Radovanović F. Supplementary information: Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. Polymer. 2018;147
Janićijević Željko, Radovanović Filip, "Supplementary information: Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations" 147 (2018)

Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations

Janićijević, Željko; Radovanović, Filip

(Elsevier, 2018)

TY  - JOUR
AU  - Janićijević, Željko
AU  - Radovanović, Filip
PY  - 2018
UR  - http://dais.sanu.ac.rs/123456789/3391
AB  - We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes
performed by combining photoirradiation with a traditional liquid phase inversion process.
Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and
75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their
microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was
crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive
and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker
were investigated in vitro using methylene blue as a model drug. Passive release kinetics was
diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was
demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot of
promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.
PB  - Elsevier
T2  - Polymer
T1  - Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations
SP  - 56
EP  - 66
VL  - 147
DO  - 10.1016/j.polymer.2018.05.065
ER  - 
@article{
author = "Janićijević, Željko and Radovanović, Filip",
year = "2018",
url = "http://dais.sanu.ac.rs/123456789/3391",
abstract = "We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes
performed by combining photoirradiation with a traditional liquid phase inversion process.
Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and
75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their
microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was
crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive
and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker
were investigated in vitro using methylene blue as a model drug. Passive release kinetics was
diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was
demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot of
promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.",
publisher = "Elsevier",
journal = "Polymer",
title = "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations",
pages = "56-66",
volume = "147",
doi = "10.1016/j.polymer.2018.05.065"
}
Janićijević, Ž.,& Radovanović, F. (2018). Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations.
PolymerElsevier., 147, 56-66.
https://doi.org/10.1016/j.polymer.2018.05.065
Janićijević Ž, Radovanović F. Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. Polymer. 2018;147:56-66
Janićijević Željko, Radovanović Filip, "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations" 147 (2018):56-66,
https://doi.org/10.1016/j.polymer.2018.05.065 .
5
4
5

Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation

Janićijević, Željko; Vujčić, Ivica T.; Vujisić, Miloš Lj.; Radovanović, Filip

(Belgrade : Institute of Technical Sciences of SASA, 2018)

TY  - CONF
AU  - Janićijević, Željko
AU  - Vujčić, Ivica T.
AU  - Vujisić, Miloš Lj.
AU  - Radovanović, Filip
PY  - 2018
UR  - http://dais.sanu.ac.rs/123456789/4720
AB  - Composite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia
T1  - Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation
SP  - 28
EP  - 28
ER  - 
@conference{
author = "Janićijević, Željko and Vujčić, Ivica T. and Vujisić, Miloš Lj. and Radovanović, Filip",
year = "2018",
url = "http://dais.sanu.ac.rs/123456789/4720",
abstract = "Composite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia",
title = "Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation",
pages = "28-28"
}
Janićijević, Ž., Vujčić, I. T., Vujisić, M. Lj.,& Radovanović, F. (2018). Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation.
Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, SerbiaBelgrade : Institute of Technical Sciences of SASA., 28-28.
Janićijević Ž, Vujčić IT, Vujisić ML, Radovanović F. Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation. Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia. 2018;:28-28
Janićijević Željko, Vujčić Ivica T., Vujisić Miloš Lj., Radovanović Filip, "Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation" (2018):28-28

Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations

Janićijević, Željko; Radovanović, Filip

(Elsevier, 2018)

TY  - JOUR
AU  - Janićijević, Željko
AU  - Radovanović, Filip
PY  - 2018
UR  - http://dais.sanu.ac.rs/123456789/4526
AB  - We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.
PB  - Elsevier
T2  - Polymer
T1  - Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations
SP  - 56
EP  - 66
VL  - 147
DO  - 10.1016/j.polymer.2018.05.065
ER  - 
@article{
author = "Janićijević, Željko and Radovanović, Filip",
year = "2018",
url = "http://dais.sanu.ac.rs/123456789/4526",
abstract = "We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.",
publisher = "Elsevier",
journal = "Polymer",
title = "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations",
pages = "56-66",
volume = "147",
doi = "10.1016/j.polymer.2018.05.065"
}
Janićijević, Ž.,& Radovanović, F. (2018). Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations.
PolymerElsevier., 147, 56-66.
https://doi.org/10.1016/j.polymer.2018.05.065
Janićijević Ž, Radovanović F. Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. Polymer. 2018;147:56-66
Janićijević Željko, Radovanović Filip, "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations" 147 (2018):56-66,
https://doi.org/10.1016/j.polymer.2018.05.065 .
5
4
5

Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations

Janićijević, Željko; Ninkov, Marina; Kataranovski, Marina; Radovanović, Filip

(Belgrade : Institute of Technical Sciences of SASA, 2017)

TY  - CONF
AU  - Janićijević, Željko
AU  - Ninkov, Marina
AU  - Kataranovski, Marina
AU  - Radovanović, Filip
PY  - 2017
UR  - http://dais.sanu.ac.rs/123456789/15452
AB  - Composites of biodegradable polymers and hydrogels are promising materials for controlled delivery systems with prolonged drug release. In this contribution, we present an innovative implant design comprising poly(DL-lactide-co-ε-caprolactone) copolymer base and a crosslinked poly(acrylic acid) hydrogel. Implants were prepared in the form of disks using the modified traditional liquid phase inversion process. Solutions containing all implant precursors were dispensed into transparent non-stick molds and cured by UV irradiation. UV curing was followed by immersion into the phosphate buffer solution bath to achieve phase separation and solidification. Structure and composition of the implant were characterized using SEM and FTIR. Obtained implants exhibited high loading capacity for cationic formulations and a moderate degree of swelling. Studies of implant loading and subsequent release of methylene blue into the phosphate-buffered saline demonstrated diffusioncontrolled delivery kinetics over a period of several weeks. To assess biocompatibility of implants as possible materials for drug delivery systems in mammals, we evaluated their effects on viability (Trypan blue exclusion assay), metabolic activity, proliferation (MTT assay) and priming (nitric oxide/NO production) of freshly isolated rat splenocytes during 24 h and 48 h of cultivation. The viability was unaltered, metabolic activity/proliferation was increased after 48 h and the decrease of NO production, as well as drop in responsiveness to cell mitogen concanavalin A (ConA) in cells on implants were observed. These results suggest that implants could be used as a suitable material for drug delivery systems, but their capacity to stimulate cell proliferation and their immunosuppressive potential deserve further investigations.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia
T1  - Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations
SP  - 9
EP  - 9
ER  - 
@conference{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Marina and Radovanović, Filip",
year = "2017",
url = "http://dais.sanu.ac.rs/123456789/15452",
abstract = "Composites of biodegradable polymers and hydrogels are promising materials for controlled delivery systems with prolonged drug release. In this contribution, we present an innovative implant design comprising poly(DL-lactide-co-ε-caprolactone) copolymer base and a crosslinked poly(acrylic acid) hydrogel. Implants were prepared in the form of disks using the modified traditional liquid phase inversion process. Solutions containing all implant precursors were dispensed into transparent non-stick molds and cured by UV irradiation. UV curing was followed by immersion into the phosphate buffer solution bath to achieve phase separation and solidification. Structure and composition of the implant were characterized using SEM and FTIR. Obtained implants exhibited high loading capacity for cationic formulations and a moderate degree of swelling. Studies of implant loading and subsequent release of methylene blue into the phosphate-buffered saline demonstrated diffusioncontrolled delivery kinetics over a period of several weeks. To assess biocompatibility of implants as possible materials for drug delivery systems in mammals, we evaluated their effects on viability (Trypan blue exclusion assay), metabolic activity, proliferation (MTT assay) and priming (nitric oxide/NO production) of freshly isolated rat splenocytes during 24 h and 48 h of cultivation. The viability was unaltered, metabolic activity/proliferation was increased after 48 h and the decrease of NO production, as well as drop in responsiveness to cell mitogen concanavalin A (ConA) in cells on implants were observed. These results suggest that implants could be used as a suitable material for drug delivery systems, but their capacity to stimulate cell proliferation and their immunosuppressive potential deserve further investigations.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia",
title = "Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations",
pages = "9-9"
}
Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F. (2017). Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations.
Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, SerbiaBelgrade : Institute of Technical Sciences of SASA., 9-9.
Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations. Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia. 2017;:9-9
Janićijević Željko, Ninkov Marina, Kataranovski Marina, Radovanović Filip, "Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations" (2017):9-9

Alternating current electric field modified synthesis of hydroxyapatite bioceramics

Janićijević, Željko; Lukić, Miodrag J.; Veselinović, Ljiljana

(Elsevier, 2016)

TY  - JOUR
AU  - Janićijević, Željko
AU  - Lukić, Miodrag J.
AU  - Veselinović, Ljiljana
PY  - 2016
UR  - http://dais.sanu.ac.rs/123456789/15977
AB  - This study presents an innovative approach towards wet chemical synthesis of hydroxyapatite bioceramics by application of alternating current (AC) electric field during the synthesis at low and intermediate temperatures. Specially designed low-cost electrical setup provided stable, reliable and modular system which supplied electric energy within the reaction volume as characterized by computer simulation of reaction conditions. Energy introduced through external excitation (alternating voltage amplitude of 10 V and frequency of 1 kHz) influenced crystallization, ionic composition, sintering behavior of hydroxyapatite powders, microstructure and final phase composition of sintered ceramics. Crystallite size in [002] crystallographic direction increased with electric field assistance regardless of the synthesis temperature. Non-isothermal sintering studies showed significantly improved densification and implied better thermal stability of powders synthesized in the presence of AC field, shifting the Ca/P ratio towards stoichiometric one. Vibrational spectroscopy analysis indicated the role of charge, mobility and effective ionic radius of present ions in transferring the energy supplied with external field influencing further thermal stability of the crystal lattice. Microstructural investigation and phase composition analysis suggested that application of AC electric field during the synthesis of nanocrystalline hydroxyapatite improved material properties and offered potential for tailoring macro/micro-porosity with precise modulation of electrical parameters.
PB  - Elsevier
T2  - Materials and Design
T1  - Alternating current electric field modified synthesis of hydroxyapatite bioceramics
SP  - 511
EP  - 519
VL  - 109
DO  - 10.1016/j.matdes.2016.07.061
ER  - 
@article{
author = "Janićijević, Željko and Lukić, Miodrag J. and Veselinović, Ljiljana",
year = "2016",
url = "http://dais.sanu.ac.rs/123456789/15977",
abstract = "This study presents an innovative approach towards wet chemical synthesis of hydroxyapatite bioceramics by application of alternating current (AC) electric field during the synthesis at low and intermediate temperatures. Specially designed low-cost electrical setup provided stable, reliable and modular system which supplied electric energy within the reaction volume as characterized by computer simulation of reaction conditions. Energy introduced through external excitation (alternating voltage amplitude of 10 V and frequency of 1 kHz) influenced crystallization, ionic composition, sintering behavior of hydroxyapatite powders, microstructure and final phase composition of sintered ceramics. Crystallite size in [002] crystallographic direction increased with electric field assistance regardless of the synthesis temperature. Non-isothermal sintering studies showed significantly improved densification and implied better thermal stability of powders synthesized in the presence of AC field, shifting the Ca/P ratio towards stoichiometric one. Vibrational spectroscopy analysis indicated the role of charge, mobility and effective ionic radius of present ions in transferring the energy supplied with external field influencing further thermal stability of the crystal lattice. Microstructural investigation and phase composition analysis suggested that application of AC electric field during the synthesis of nanocrystalline hydroxyapatite improved material properties and offered potential for tailoring macro/micro-porosity with precise modulation of electrical parameters.",
publisher = "Elsevier",
journal = "Materials and Design",
title = "Alternating current electric field modified synthesis of hydroxyapatite bioceramics",
pages = "511-519",
volume = "109",
doi = "10.1016/j.matdes.2016.07.061"
}
Janićijević, Ž., Lukić, M. J.,& Veselinović, L. (2016). Alternating current electric field modified synthesis of hydroxyapatite bioceramics.
Materials and DesignElsevier., 109, 511-519.
https://doi.org/10.1016/j.matdes.2016.07.061
Janićijević Ž, Lukić MJ, Veselinović L. Alternating current electric field modified synthesis of hydroxyapatite bioceramics. Materials and Design. 2016;109:511-519
Janićijević Željko, Lukić Miodrag J., Veselinović Ljiljana, "Alternating current electric field modified synthesis of hydroxyapatite bioceramics" 109 (2016):511-519,
https://doi.org/10.1016/j.matdes.2016.07.061 .
2
4
3

pH-sensitive membranes with crosslinked poly(acrylic acid) hydrogel for controlled delivery

Janićijević, Željko; Radovanović, Filip

(Belgrade : Institute of Technical Sciences of SASA, 2016)

TY  - CONF
AU  - Janićijević, Željko
AU  - Radovanović, Filip
PY  - 2016
UR  - http://dais.sanu.ac.rs/123456789/887
AB  - Polymeric pH-sensitive membranes and hydrogels are interesting materials for the controlled delivery of chemical agents triggered by external stimuli. In this contribution, we present a novel membrane design consisting of a polyethersulfone polymeric base and a crosslinked poly(acrylic acid) hydrogel containing pH-responsive carboxyl groups. Membranes were prepared using the modified traditional liquid phase inversion process. Solutions containing all membrane precursors were cast on a glass plate and cured by UV irradiation. UV curing was followed by immersion into the water bath to achieve phase separation and solidification. Obtained membranes exhibited high ion-exchange capacity and a moderate swelling degree dependent on the crosslinker properties. Studies of membrane loading with methylene blue and subsequent release of methylene blue from the membrane into the alkaline and acidic buffered solutions demonstrated pH-dependent delivery kinetics.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Fifteenth Young Researchers' Conference Materials Sciences and Engineering, December 7-9, 2016, Belgrade
T1  - pH-sensitive membranes with crosslinked poly(acrylic acid) hydrogel for controlled delivery
SP  - 55
EP  - 55
ER  - 
@conference{
author = "Janićijević, Željko and Radovanović, Filip",
year = "2016",
url = "http://dais.sanu.ac.rs/123456789/887",
abstract = "Polymeric pH-sensitive membranes and hydrogels are interesting materials for the controlled delivery of chemical agents triggered by external stimuli. In this contribution, we present a novel membrane design consisting of a polyethersulfone polymeric base and a crosslinked poly(acrylic acid) hydrogel containing pH-responsive carboxyl groups. Membranes were prepared using the modified traditional liquid phase inversion process. Solutions containing all membrane precursors were cast on a glass plate and cured by UV irradiation. UV curing was followed by immersion into the water bath to achieve phase separation and solidification. Obtained membranes exhibited high ion-exchange capacity and a moderate swelling degree dependent on the crosslinker properties. Studies of membrane loading with methylene blue and subsequent release of methylene blue from the membrane into the alkaline and acidic buffered solutions demonstrated pH-dependent delivery kinetics.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Fifteenth Young Researchers' Conference Materials Sciences and Engineering, December 7-9, 2016, Belgrade",
title = "pH-sensitive membranes with crosslinked poly(acrylic acid) hydrogel for controlled delivery",
pages = "55-55"
}
Janićijević, Ž.,& Radovanović, F. (2016). pH-sensitive membranes with crosslinked poly(acrylic acid) hydrogel for controlled delivery.
Program and the Book of Abstracts / Fifteenth Young Researchers' Conference Materials Sciences and Engineering, December 7-9, 2016, BelgradeBelgrade : Institute of Technical Sciences of SASA., 55-55.
Janićijević Ž, Radovanović F. pH-sensitive membranes with crosslinked poly(acrylic acid) hydrogel for controlled delivery. Program and the Book of Abstracts / Fifteenth Young Researchers' Conference Materials Sciences and Engineering, December 7-9, 2016, Belgrade. 2016;:55-55
Janićijević Željko, Radovanović Filip, "pH-sensitive membranes with crosslinked poly(acrylic acid) hydrogel for controlled delivery" (2016):55-55

Reliable low-cost experimental setup for material synthesis modification by applying alternating electric fields

Janićijević, Željko; Lukić, Miodrag J.

(Belgrade : Institute of Technical Sciences of SASA, 2015)

TY  - CONF
AU  - Janićijević, Željko
AU  - Lukić, Miodrag J.
PY  - 2015
UR  - http://dais.sanu.ac.rs/123456789/835
AB  - Building of laboratory hardware in-house can reduce overall equipment costs and respond to the specific requirements of the experiment. The aim of this contribution is to present the novel design and implementation of the low-cost module for AC electric excitation of chemical systems, mainly intended for modifying wet chemical synthesis of nanomaterials. Results of preliminary modelling and experimental tests indicate good module reliability and applicability of the modification methodology on various material types (ceramics, metals and proteins). Possible underlying mechanisms correlating the influence of alternating electric fields and material properties, as well as potential improvements in module construction are discussed.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, Serbia
T1  - Reliable low-cost experimental setup for material synthesis modification by applying alternating electric fields
SP  - 23
EP  - 23
ER  - 
@conference{
author = "Janićijević, Željko and Lukić, Miodrag J.",
year = "2015",
url = "http://dais.sanu.ac.rs/123456789/835",
abstract = "Building of laboratory hardware in-house can reduce overall equipment costs and respond to the specific requirements of the experiment. The aim of this contribution is to present the novel design and implementation of the low-cost module for AC electric excitation of chemical systems, mainly intended for modifying wet chemical synthesis of nanomaterials. Results of preliminary modelling and experimental tests indicate good module reliability and applicability of the modification methodology on various material types (ceramics, metals and proteins). Possible underlying mechanisms correlating the influence of alternating electric fields and material properties, as well as potential improvements in module construction are discussed.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, Serbia",
title = "Reliable low-cost experimental setup for material synthesis modification by applying alternating electric fields",
pages = "23-23"
}
Janićijević, Ž.,& Lukić, M. J. (2015). Reliable low-cost experimental setup for material synthesis modification by applying alternating electric fields.
Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, SerbiaBelgrade : Institute of Technical Sciences of SASA., 23-23.
Janićijević Ž, Lukić MJ. Reliable low-cost experimental setup for material synthesis modification by applying alternating electric fields. Program and the Book of Abstracts / Fourteenth Young Researchers' Conference Materials Sciences and Engineering, December 9-11, 2015, Belgrade, Serbia. 2015;:23-23
Janićijević Željko, Lukić Miodrag J., "Reliable low-cost experimental setup for material synthesis modification by applying alternating electric fields" (2015):23-23