TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Janković, Radmila
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2019
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/tx/c9tx00007k
UR  - https://dais.sanu.ac.rs/123456789/4961
AB  - Reconstruction of bone defects with the use of biomaterials based on hydroxyapatite (HAp) has been a popular approach in medicine and dentistry. Most often the process of new bone formation is analyzed with the focus only on the region of the reconstructed defect. The effects of the therapy on distant organs have been rarely reported in literature, especially not in synergy with the exposure to other bioactive chemicals. In this study, reconstruction of the mandibular bone in vivo using poly-lactide-co-glycolide-coated HAp (HAp/PLGA) nanoparticles was monitored with a simultaneous histopathological analysis of distant organs, specifically kidney and liver parenchyma. Heavy metals are among the most prominent environmental pollutants and have a high affinity for the crystal lattice of HAp, where they get incorporated by replacing calcium ions. Lead (Pb) and cadmium (Cd) are two such metals that can be found in food, water and air, but are most commonly present in cigarette smoke, the frequent contaminant of hospital settings in the developing world. A study performed on 24 female Wistar rats demonstrated that the reconstruction of mandibular bone defects using HAp/PLGA particles induced an increase in the content of Ca in the newly created bone without causing any pathological changes to the liver and the kidneys. The presence of Pb and Cd in the defects reconstructed with HAp/PLGA nanoparticles impeded the regenerative process and led to a severe and irreversible damage to the liver and kidney parenchyma.
T2  - Toxicology Research
T1  - Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects
SP  - 287
EP  - 296
VL  - 8
DO  - 10.1039/C9TX00007K
UR  - https://hdl.handle.net/21.15107/rcub_dais_4961
ER  - 

@article{
author = "Ignjatović, Nenad and Janković, Radmila and Uskoković, Vuk and Uskoković, Dragan",
year = "2019",
abstract = "Reconstruction of bone defects with the use of biomaterials based on hydroxyapatite (HAp) has been a popular approach in medicine and dentistry. Most often the process of new bone formation is analyzed with the focus only on the region of the reconstructed defect. The effects of the therapy on distant organs have been rarely reported in literature, especially not in synergy with the exposure to other bioactive chemicals. In this study, reconstruction of the mandibular bone in vivo using poly-lactide-co-glycolide-coated HAp (HAp/PLGA) nanoparticles was monitored with a simultaneous histopathological analysis of distant organs, specifically kidney and liver parenchyma. Heavy metals are among the most prominent environmental pollutants and have a high affinity for the crystal lattice of HAp, where they get incorporated by replacing calcium ions. Lead (Pb) and cadmium (Cd) are two such metals that can be found in food, water and air, but are most commonly present in cigarette smoke, the frequent contaminant of hospital settings in the developing world. A study performed on 24 female Wistar rats demonstrated that the reconstruction of mandibular bone defects using HAp/PLGA particles induced an increase in the content of Ca in the newly created bone without causing any pathological changes to the liver and the kidneys. The presence of Pb and Cd in the defects reconstructed with HAp/PLGA nanoparticles impeded the regenerative process and led to a severe and irreversible damage to the liver and kidney parenchyma.",
journal = "Toxicology Research",
title = "Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects",
pages = "287-296",
volume = "8",
doi = "10.1039/C9TX00007K",
url = "https://hdl.handle.net/21.15107/rcub_dais_4961"
}

Ignjatović, N., Janković, R., Uskoković, V.,& Uskoković, D.. (2019). Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects. in Toxicology Research, 8, 287-296.
https://doi.org/10.1039/C9TX00007K
https://hdl.handle.net/21.15107/rcub_dais_4961

Ignjatović N, Janković R, Uskoković V, Uskoković D. Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects. in Toxicology Research. 2019;8:287-296.
doi:10.1039/C9TX00007K
https://hdl.handle.net/21.15107/rcub_dais_4961 .

Ignjatović, Nenad, Janković, Radmila, Uskoković, Vuk, Uskoković, Dragan, "Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects" in Toxicology Research, 8 (2019):287-296,
https://doi.org/10.1039/C9TX00007K .,
https://hdl.handle.net/21.15107/rcub_dais_4961 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Janković, Radmila
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2019
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/tx/c9tx00007k
UR  - https://dais.sanu.ac.rs/123456789/4847
AB  - Reconstruction of bone defects with the use of biomaterials based on hydroxyapatite (HAp) has been a popular approach in medicine and dentistry. Most often the process of new bone formation is analyzed with the focus only on the region of the reconstructed defect. The effects of the therapy on distant organs have been rarely reported in literature, especially not in synergy with the exposure to other bioactive chemicals. In this study, reconstruction of the mandibular bone in vivo using poly-lactide-co-glycolide-coated HAp (HAp/PLGA) nanoparticles was monitored with a simultaneous histopathological analysis of distant organs, specifically kidney and liver parenchyma. Heavy metals are among the most prominent environmental pollutants and have a high affinity for the crystal lattice of HAp, where they get incorporated by replacing calcium ions. Lead (Pb) and cadmium (Cd) are two such metals that can be found in food, water and air, but are most commonly present in cigarette smoke, the frequent contaminant of hospital settings in the developing world. A study performed on 24 female Wistar rats demonstrated that the reconstruction of mandibular bone defects using HAp/PLGA particles induced an increase in the content of Ca in the newly created bone without causing any pathological changes to the liver and the kidneys. The presence of Pb and Cd in the defects reconstructed with HAp/PLGA nanoparticles impeded the regenerative process and led to a severe and irreversible damage to the liver and kidney parenchyma.
T2  - Toxicology Research
T1  - Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects
SP  - 287
EP  - 296
VL  - 8
DO  - 10.1039/C9TX00007K
UR  - https://hdl.handle.net/21.15107/rcub_dais_4847
ER  - 

@article{
author = "Ignjatović, Nenad and Janković, Radmila and Uskoković, Vuk and Uskoković, Dragan",
year = "2019",
abstract = "Reconstruction of bone defects with the use of biomaterials based on hydroxyapatite (HAp) has been a popular approach in medicine and dentistry. Most often the process of new bone formation is analyzed with the focus only on the region of the reconstructed defect. The effects of the therapy on distant organs have been rarely reported in literature, especially not in synergy with the exposure to other bioactive chemicals. In this study, reconstruction of the mandibular bone in vivo using poly-lactide-co-glycolide-coated HAp (HAp/PLGA) nanoparticles was monitored with a simultaneous histopathological analysis of distant organs, specifically kidney and liver parenchyma. Heavy metals are among the most prominent environmental pollutants and have a high affinity for the crystal lattice of HAp, where they get incorporated by replacing calcium ions. Lead (Pb) and cadmium (Cd) are two such metals that can be found in food, water and air, but are most commonly present in cigarette smoke, the frequent contaminant of hospital settings in the developing world. A study performed on 24 female Wistar rats demonstrated that the reconstruction of mandibular bone defects using HAp/PLGA particles induced an increase in the content of Ca in the newly created bone without causing any pathological changes to the liver and the kidneys. The presence of Pb and Cd in the defects reconstructed with HAp/PLGA nanoparticles impeded the regenerative process and led to a severe and irreversible damage to the liver and kidney parenchyma.",
journal = "Toxicology Research",
title = "Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects",
pages = "287-296",
volume = "8",
doi = "10.1039/C9TX00007K",
url = "https://hdl.handle.net/21.15107/rcub_dais_4847"
}

Ignjatović, N., Janković, R., Uskoković, V.,& Uskoković, D.. (2019). Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects. in Toxicology Research, 8, 287-296.
https://doi.org/10.1039/C9TX00007K
https://hdl.handle.net/21.15107/rcub_dais_4847

Ignjatović N, Janković R, Uskoković V, Uskoković D. Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects. in Toxicology Research. 2019;8:287-296.
doi:10.1039/C9TX00007K
https://hdl.handle.net/21.15107/rcub_dais_4847 .

Ignjatović, Nenad, Janković, Radmila, Uskoković, Vuk, Uskoković, Dragan, "Effects of Hydroxyapatite@Poly-Lactide-Co-Glycolide Nanoparticles Combined with Pb and Cd on Liver and Kidney Parenchyma after the Reconstruction of Mandibular Bone Defects" in Toxicology Research, 8 (2019):287-296,
https://doi.org/10.1039/C9TX00007K .,
https://hdl.handle.net/21.15107/rcub_dais_4847 .